Seroprevalence of hepatitis A in children and adolescents

Markus, Jandrei Rogério; Cruz, Cristina Rodrigues; Maluf, Eliane Mara Cesário Pereira; Tahan, Tony Tannous; Hoffmann, Murilo M.

doi:10.2223/jped.2119

Cited by 11 publications

(11 citation statements)

References 28 publications

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“…As observed by other authors (8,10,14) , living environment clusters were predictive of positivity for anti-HAV. In the settlement projects investigated, individuals who reported more than five people living in the same household had almost a 20% risk of being anti-HAV positive (RP:1.18; P=0.007).…”

Section: Discussionsupporting

confidence: 80%

Intermediate Endemicity of Hepatitis a Virus Infection in Rural Settlement Projects of Southwest Goiás, Brazil

Pinheiro

Araújo

Caetano

et al. 2015

Arq. Gastroenterol.

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-Background -Rural populations present an elevated risk of exposure to hepatitis A virus. Objective -The objective of this study was to estimate the prevalence and risk factors associated with hepatitis A virus infection among residents of rural settlement projects of southwest Goiás, Central Brazil. Methods -A total of 466 residents were interviewed and tested for the detection of anti-hepatitis A virus antibodies by ELISA. Results -The global prevalence of anti-hepatitis A virus was 82.2%. In individuals aged 5-9 years and 10-19 years, the prevalence was 15% and 58.8%, respectively. Persons in the 10-19 age group, with a history of life in encampments, with more than five people per residence consuming well water, were predictors for exposure to hepatitis A virus. Conclusion -Our results suggest that the hepatitis A virus endemicity in rural settlements in southwest Goiás similar to that found in the urban population of the Midwest Region, confirming the implementation of universal hepatitis A vaccination in children. HEADINGS -Hepatitis A. Prevalence. Squatter settlements.

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Section: Discussionsupporting

confidence: 80%

Intermediate Endemicity of Hepatitis a Virus Infection in Rural Settlement Projects of Southwest Goiás, Brazil

Pinheiro

Araújo

Caetano

et al. 2015

Arq. Gastroenterol.

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“…In the Brazilian Northeast, one of the country's poorest regions, the highest prevalence is found in children under 5 years 6,7 . Other studies conducted in poor areas from wealthier municipalities around the country, such as the city of Santos, São Paulo in 2007 8 and the metropolitan region of Curitiba, Paraná in 2006 9 found similar results to those obtained in the Northeast, with a higher frequency of HAV infection observed in children under 5 years.…”

Section: Discussionsupporting

confidence: 68%

Trend of Acute Hepatitis a in the State of Bahia, Brazil Over a 5-Year Period

Pereira¹,

Almeida²,

Lírio³

et al. 2017

BJMHH

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were included. Percentages of HAV positive cases were presented according to age range for each year of the 5-year study and for each of the nine health districts (RHC) of Bahia. Results: 21,175 samples were analyzed. Proportion of HAV infection was 7.2% (1,535 / 21,175) throughout the study period. The highest proportion was in 2009 (17.4%) and the lowest in 2012 (3.8%), demonstrating a decreasing trend (r = 0.7). The highest infection rates were found in children up to 10 years old. HAV infection was more frequent among males among all age groups. 52.4% (184/351) of the municipalities had acute HAV cases diagnosed. The North and West regions had the highest number of cases. Conclusion: There was a progressive decrease of approximately 70% in the proportion of acute HAV infection in the state of Bahia during a five-year assessment period. However, children up to 10 years old remain at higher risk, therefore the vaccine should be expanded to reach this age range.

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“…In Brazil, seroprevalence studies conducted recently mainly in urban areas, showed a consistent decrease of the incidence rates in childhood 4,5,6,7,8,9,10 . Decrease in HAV circulation 8,9,11,12 as well as a progressive decline in fatal cases related to HAV infection in all Brazilian regions 8 have also begun to be noticed.…”

mentioning

confidence: 84%

Hepatitis A seroprevalence in public school children in Campos dos Goytacazes, Rio de Janeiro State, Brazil, prior to the introduction of the hepatitis A universal childhood vaccination

et al. 2016

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This cross-sectional study was carried out between August 2011 and July 2012 in the city of Campos dos Goytacazes in Rio de Janeiro State, Brazil. Dried blood spot samples were collected on filter paper from 919 individuals between the ages of 1 and 19 and were tested for antibodies against the hepatitis A virus (anti-HAV). The total prevalence was 20.7%, while 94.7% of children under the age of 5 were found to be susceptible to HAV infection. The prevalence of anti-HAV increased with age, reaching 33.3% among individuals aged between 15 and 19, thereby indicating that this municipality has a low level of endemicity for hepatitis A. Age, non-white skin color, accustomed to swimming in the river and more than five people living at home were the factors that were associated with an increase in the chance of a positive anti-HAV result. Mother's education level (secondary or tertiary) was considered a protective factor for HAV infection. The data obtained showed that a large proportion of the children from Campos dos Goytacazes were at risk of HAV infection, which should be minimized with the introduction of the vaccination program against hepatitis A that was launched in the municipality in 2011.

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Seroprevalence of hepatitis A in children and adolescents

Cited by 11 publications

References 28 publications

Intermediate Endemicity of Hepatitis a Virus Infection in Rural Settlement Projects of Southwest Goiás, Brazil

Intermediate Endemicity of Hepatitis a Virus Infection in Rural Settlement Projects of Southwest Goiás, Brazil

Trend of Acute Hepatitis a in the State of Bahia, Brazil Over a 5-Year Period

Hepatitis A seroprevalence in public school children in Campos dos Goytacazes, Rio de Janeiro State, Brazil, prior to the introduction of the hepatitis A universal childhood vaccination

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