Seroprevalence of hepatitis B virus serological markers among pregnant Nigerian women

Oneh, Henrietta; Aminu, Maryam

doi:10.4103/1596-3519.172555

Cited by 23 publications

(11 citation statements)

References 26 publications

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“…Even though age has been identified to be a major determinant of HBV incidence and its, however, from this study, HBsAg detection was not significantly associated with age (P = 0.836) even though the highest prevalence was among the patient aged between 51 and 60 years. The age-specific prevalence in this study is in contrast with the findings of (Olokoba et al, 2011;Aba and Aminu, 2016) who reported that the highest prevalence was recorded in the age range 21 and 35 years. Also, our results are similar to the findings of (Manjula et al, 2018) that mentioned age factor in individuals was >40 years.…”

Section: Resultscontrasting

confidence: 99%

“…The 6.5% recorded for HBsAg in this study is higher than the 5.7% recorded in Ekiti (Opaleye et al, 2014) and lower that the 9.7% in Niger Delta (Ejele et al, 2004), 11.9% in Ibadan (Otegbayo et al, 2008), 15% in North-Eastern Nigeria (Olokoba et al, 2008) and 16.7% in Jos (Idoko et al, 2009). The prevalence recorded in this study is higher than 2.3% in Kaduna (Aba and Aminu, 2016) and lower than a 5.8% recorded in Owerri (Nwolisa et al, 2013). The geographical variation, differences in cultural practices, sexual behaviour and practices as well as differences in the test methods employed in detection can play an important role in the disease epidemiology and surveillance.…”

Section: Resultscontrasting

confidence: 54%

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Serological Markers for Hepatitis B Virus among HIV Individuals in Ogbomoso, Oyo State, Nigeria

Omolara¹,

Omotoyosi²,

Kolawole³

et al. 2019

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Human immunodeficiency virus (HIV) and Hepatitis B virus (HBV) co-infection have been associated with reduced survival, increased risk of liver disease and hepatotoxicity despite undergoing antiretroviral therapy (ART). This study aims to determine the prevalence of serological markers of HBV based on serological markers among infected individuals with HIV. Ninety-three sera samples of HIV positive individuals were collected by Ladoke Akintola University of Technology (LAUTECH) Teaching Hospital-HIV/AIDS Supporting and Counselling Unit, Ogbomoso. The collected samples were analyzed for enumeration of CD4+ cells and presence of HBV. The selected three HBV serological markers were HBsAg, HBeAg and HBcAb while using a third generation ELISA kit for screening. The mean CD4+ count and age were 479.12 ± 23.48 cells/µl and 48.56 ± 1.27 years, respectively. Only six samples out of ninety-three HIV-positive samples were positive to HBsAg while fifty-four samples (58.1%) were positive for HBcAb however, HBeAg marker was negative among all samples. Interestingly, the prevalence of the HBV infection was more in females (66.6%) compared to the male counterparts (33.3%) within the overall screening. In conclusion, the current study describes the prevalence of HBV infection amongst HIV-positive individuals in Ogbomoso. The high prevalence of HBcAb confirmed that Ogbomoso district is highly endemic with HBV infection. Likewise, HBV vaccination in HIV-infected patients is encouraged with careful monitoring for liver function, particularly those under ART.

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Section: Resultscontrasting

confidence: 99%

Section: Resultscontrasting

confidence: 54%

Serological Markers for Hepatitis B Virus among HIV Individuals in Ogbomoso, Oyo State, Nigeria

Omolara¹,

Omotoyosi²,

Kolawole³

et al. 2019

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“…The global prevalence of hepatitis B is among the highest in parts of Africa, containing an estimated 50 million chronic carriers of HBV [ 13 , 14 ]. Previous studies have shown HBsAg positive rates above 10% in African countries such as Burkina Faso, the Central African Republic, and Nigeria [ 15 – 17 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and associated knowledge of hepatitis B infection among healthcare workers in Freetown, Sierra Leone

Qin

Zhou

et al. 2018

BMC Infect Dis

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BackgroundHepatitis B virus (HBV) is considered highly prevalent in West Africa. However, major gaps in surveillance exist in Sierra Leone. Although healthcare workers (HCWs) are at high risk for HBV infection, little is known about the prevalence and knowledge of hepatitis B among HCWs in Sierra Leone.MethodsA cross-sectional study of all HCWs at the No. 34 Military Hospital located in Freetown, Sierra Leone, was conducted from March 20 to April 10, 2017. Whole blood was collected and screened for HBV markers using a one-step rapid immunochromatographic test with positive samples tested for HBV DNA. Additionally, questionnaires assessing self-reported knowledge of HBV infections were administered to all participants. Data were processed and analyzed using SPSS (version 17.0) software.ResultsA total of 211 HCWs were included in this study with a median age of 39.0 years (range: 18–59). Of the participating HCWs, 172 (81.5%) participants were susceptible (all markers negative), 21(10.0%) were current HBV (HBsAg positive) and nine (4.3%) were considered immune because of past infection (HBsAg negative and anti-HBc positive; anti-HBs positive). Additionally, nine (4.3%) participants displayed immunity to the virus as a result of prior hepatitis B vaccination (only anti-HBs positive). Of the 21 HCWs with positive HBsAg, 13 (61.9%) had detectable HBV DNA. There was a significantly lower risk for current HBV infection among HCWs older than 39 years (OR 0.337, p = 0.046). In addition, only 14 (6.6%), 73 (34.6%) and 82 (38.9%) participants in this survey had adequate knowledge about the clinical outcome, routes of transmission, and correct preventive measures of HBV infection, respectively.ConclusionsHCWs in Sierra Leone lacked adequate knowledge of the hepatitis B virus. Additionally, the low coverage rate of hepatitis B vaccination among HCWs fails to meet WHO recommendations, leaving many of the sampled HCWs susceptible to infection. This study reaffirms the need for more intensive training for HCWs in addition to strengthening vaccination programmes to protect HCWs against HBV in Sierra Leone.Electronic supplementary materialThe online version of this article (10.1186/s12879-018-3235-1) contains supplementary material, which is available to authorized users.

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“…of 26, 548. Seventeen of the 20 studies (85%) were facility-based cross-sectional studies [41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57], two studies were retrospective chart reviews [58,59], and one was a community-based cross-sectional study [60]. Half of the studies were conducted in the Northern region (North Central = 5; North East = 2; and North West = 3) [41-44, 46, 52, 54, 56, 57, 60] and the remaining 50% were conducted in the Southern region (South East = 1 and South West = 9) [45, 47-50, 53, 55, 58, 59].…”

Section: Plos Onementioning

confidence: 99%

A systematic review and meta-analysis of the prevalence of hepatitis B virus infection among pregnant women in Nigeria

Olakunde

Adeyinka

Olakunde³

et al. 2021

PLoS ONE

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Background Nigeria has a high burden of hepatitis B virus (HBV) infection, commonly acquired through vertical transmission. However, there is a lack of an efficient surveillance system for monitoring and understanding the epidemiology of HBV among pregnant women. Building on a previous review on the prevalence of HBV in Nigeria (2000–2013), we conducted a systematic review and meta-analysis of HBV prevalence among pregnant women in Nigeria. Methods Four electronic databases PubMed, Embase, Global Health, and Scopus were systematically searched from January 2014 to February 2021. We also searched the African Journal Online and manually scanned the reference lists of the identified studies for potentially eligible articles. Observational studies that reported the prevalence of HBsAg and/or HBeAg among pregnant women in peer-reviewed journals were included in the study. We performed a meta-analysis using a random-effects model. We defined HBV infection as a positive test to HBsAg. Results From the 158 studies identified, 20 studies with a total sample size of 26, 548 were included in the meta-analysis. The pooled prevalence of HBV infection among pregnant women across the studies was 6.49% (95% confidence interval [CI] = 4.75–8.46%; I2 = 96.7%, p = 0.001; n = 20). The prevalence of HBV was significantly lower among pregnant women with at least secondary education compared with those with no education or primary education (prevalence ratio = 0.7, 95% CI = 0.58–0.87; n = 10). However, the prevalence of HBV was not significantly different by age, religion, marital status, or tribe. The prevalence of HBV was not significantly different among pregnant women with previous surgery, blood transfusion, multiple lifetime sex partners, tribal marks, tattoos, scarification, or sexually transmitted infections, compared with those without these risk factors. From a total sample size of 128 (n = 7), the pooled prevalence of HBeAg among HBV-infected pregnant women was 14.59% (95% CI = 4.58–27.99%; I2 = 65.5%, p = 0.01). Subgroup analyses of HBV infection by study region and screening method, and meta-regression analysis of the study year, sample size, and quality rating were not statistically significant. Conclusions There is an intermediate endemicity of HBV infection among pregnant women in Nigeria. Interventions, such as routine antenatal HBV screening, antiviral prophylaxis for eligible pregnant women, and infant HBV vaccination should be scaled up for the prevention of perinatal transmission of HBV infection in Nigeria.

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Seroprevalence of hepatitis B virus serological markers among pregnant Nigerian women

Cited by 23 publications

References 26 publications

Serological Markers for Hepatitis B Virus among HIV Individuals in Ogbomoso, Oyo State, Nigeria

Serological Markers for Hepatitis B Virus among HIV Individuals in Ogbomoso, Oyo State, Nigeria

Prevalence and associated knowledge of hepatitis B infection among healthcare workers in Freetown, Sierra Leone

A systematic review and meta-analysis of the prevalence of hepatitis B virus infection among pregnant women in Nigeria

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