Seroprevalence of hepatitis B virus, hepatitis C virus, and human immunodeficiency virus among volunteer blood donors in the National Blood Transfusion Center of Lome

Nadjir, Liza Koboyo; Kolou, M; Katawa, Gnatoulma; Kwarteng, Alexander; Issa, A; Mawussi, Hèzouwè Magnang; Feteke, L; Segbena, Koffi Yvon

doi:10.5348/ijbti-2017-33-oa-6

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…In this study, men were more represented than women among the blood donors; the sex-ratio M/F was 16. We found this male predominance at the CNTS of Lomé in previous studies done in 2012 [14] and 2015 [15]. Other studies found this male predominance with 94.36% in Mali by Goita et al [16], 80% in Sierra Leone by Yambasu et al [17].…”

Section: Socio-demographic Characteristics Of the Study Populationsupporting

confidence: 69%

Anti-HBc antibodies and occult hepatitis B infection (OBI) among blood donors in Lomé, Togo

Koboyo Nadjir,

Katawa,

Kolou

et al. 2024

Int J Blood Transfus Immunohematol

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Aims: Among the progressive forms of hepatitis B virus (HBV) infections, the HBs antigen (HBsAg) remains undetectable in 25% of cases. There is also a form of HBV infection called occult HBV infection (OBI) characterized by the presence of viral DNA in the blood and tissues with no detectable levels of HBsAg associated with or without anti-HBc Ab, or anti-HBs Ab out of the pre-seroconversion period, which constitutes an infectious risk in blood transfusion. Methods: To determine the prevalence of anti-HBc Abs and the HBV DNA in the blood of donors recruited at the blood transfusion center (CNTS) of Lomé. This is a cross-sectional study including 967 blood donations which were seronegative to HBs antigen during the biological qualification of the donation (BQD) from July 28 to August 19, 2022. The detection of total anti-HBc Abs (IgM and IgG) was performed by BIORAD enzyme-linked immunosorbent assay (ELISA) method; the viral load measurement was carried out according to the polymerase chain reaction method by amplification of COBAS AmpliPrep/TaqMan 4800 (Roche diagnostics). Data processing and analysis were performed using EXCEL 2013 software and SPSS software. Concerning the ethical aspect, we have obtained written consent from the donors and the agreement of the bioethics committee for health research No. 052/2022/CBRS. Results: The prevalence of anti-HBc Abs was 33.82% (CI: 30.83–36.80). Viral DNA was detected in 10 cases. The prevalence of occult hepatitis B was 3.05% (10/327) in blood donors carrying anti-HBc antibodies, and 1.03% (10/967) in the blood donors population that does not carry HBsAg. Conclusion: The presence of occult hepatitis B within the population of blood donors at the blood transfusion center of Lomé constitutes a real threat to transfusion safety. The association of the viral DNA detection by PCR to the serological tests that are currently carried out during the biological qualification of the donations could be a better approach to reduce the risk of transmission of HBV by blood transfusion at the CNTS of Lomé.

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Section: Socio-demographic Characteristics Of the Study Populationsupporting

confidence: 69%

Anti-HBc antibodies and occult hepatitis B infection (OBI) among blood donors in Lomé, Togo

Koboyo Nadjir,

Katawa,

Kolou

et al. 2024

Int J Blood Transfus Immunohematol

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“…En Afrique subsaharienne, les infections dues au VIH, au virus de l'hépatite B (VHB), au virus de l'hépatite C (VHC) et au paludisme sont des problèmes majeurs de santé publique [2]. Au Togo, entre 2011 et 2015, les prévalences respectives des hépatites virales B, C et du VIH dans une étude au Centre National de Transfusion (CNTS) de Lomé chez les donneurs de sang étaient respectivement de 2,63%, 1,58% et 0,92% [4].…”

Section: Introductionunclassified

Prévalence des marqueurs infectieux chez les donneurs de sang au centre régional de transfusion sanguine de Sokodé

Bawè,

2024

Rev Mali Infectiol Microbiol

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Introduction : L’impact des maladies infectieuses émergentes sur la sécurité transfusionnelle peut être exploré à travers les systèmes d’hémovigilance. L’objectif de cette étude était d’estimer la prévalence de l’hépatite B et C, le VIH et la syphilis chez les donneurs de sang à Sokodé (Togo). Méthodes : Une étude rétrospective a été menée au Centre Régional de Transfusion Sanguine de Sokodé du 1er Janvier au 31 Décembre 2018. Tous les dons de sang testés pour les quatre marqueurs infectieux durant la période d’étude ont été inclus. Les données collectées ont été encodées, saisies et analysées à l’aide du logiciel Transfus Control 4.5. Nos résultats ont été présentés sous forme d’effectifs et de fréquences. Résultats : Le total des dons obtenus durant la période d’étude était de 12.063. Tous les donneurs de sang étaient des donneurs volontaires, majoritairement jeunes (95,76% des donneurs était âgé de moins de 40 ans). Nous avons noté une prédominance masculine (84,5% d’hommes et 15,5% de femmes). La prévalence globale des marqueurs s’élevait à 5,76%.Les prévalences spécifiques étaient respectivement de 4,88 % ; 0,78 % ; 0,1% et 00% pour l’hépatite B, l’hépatite C, le VIH et la syphilis. La prévalence pour la co-infection hépatite B-hépatite C enregistrée était de 0,049%. L’hépatite B représentait l’infection majoritaire (84,16%). Conclusion : La prévalence de l’hépatite B était élevée et très alarmante.

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“…Humanity has been struggling against pathogens. Theses pathogens cause parasitic diseases [1] , bacterial infections and viral such us HIV [2] , hepatitis B [3,4] and recent Covid-19 causes by SARS-CoV-2 [5] . Coronaviridae are single-stranded, positive-sense RNA viruses enveloped non-segmented, designated after their corona or crown-like on electron microscopy [6,7] .…”

Section: Introductionmentioning

confidence: 99%

Human Coronaviruses: Genetics, Virulence Factors and Pathophysiology, Diseases’ Epidemiology

Katawa

Gambogou

Nguepou

et al. 2021

ijirms

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Coronaviruses are pathogens for both animals and humans. The recent Coronavirus Disease (Covid-19), caused by a novel Coronavirus (SARS-CoV-2), outbreak that took place in Hubei (Wuhan, China) from December 2019 aroused numerous questions regarding the nature and the origin of the SARS-CoV-2. Literature review of the main publications from scientific data bases was undertaken. These data revealed similarities of symptoms and identity of genome with the SARS-CoV. In this review, the genetics and virulence factors of coronaviruses, the disease pathophysiology and epidemiology were examined.

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Seroprevalence of hepatitis B virus, hepatitis C virus, and human immunodeficiency virus among volunteer blood donors in the National Blood Transfusion Center of Lome

Cited by 4 publications

References 24 publications

Anti-HBc antibodies and occult hepatitis B infection (OBI) among blood donors in Lomé, Togo

Anti-HBc antibodies and occult hepatitis B infection (OBI) among blood donors in Lomé, Togo

Prévalence des marqueurs infectieux chez les donneurs de sang au centre régional de transfusion sanguine de Sokodé

Human Coronaviruses: Genetics, Virulence Factors and Pathophysiology, Diseases’ Epidemiology

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