Seroprevalence of hepatitis C in renal failure patients on maintenance hemodialysis - Study in a tertiary care hospital - Western India

Subramanian, Geetha Priyadharsini; Vegad, Mahendra; Vadsmiya, Minesh G; Murawala, Sweta M; Patel, Falguni V

doi:10.5455/ijmsph.2016.22072015109

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…3 In our study anti-HCV antibodies were found in 28.8% of patients. This is lower than studies conducted by Rawat 3,7,[9][10][11] Worldwide prevalence rate ranging from 4-15% for HBsAg in HD patients has been reported, whereas, in India it ranges from 3.4% to 45%. 4,12 We report 14.8% HBV positivity among HD patients which in agreement with the study conducted by Mittal et al (10.2%), Bhaumika et al (12.1%).…”

Section: Discussioncontrasting

confidence: 59%

Prevalence of asymptomatic hepatitis B virus and hepatitis C virus infections in patients with maintenance hemodialysis of a tertiary care hospital in western Maharashtra

Patil¹,

Munjappa²,

Gadgil³

et al. 2020

IJMR

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Introduction: Patients on Maintenance Hemodialysis (HD) are at high risk of viral hepatitis due to blood transfusion, prolonged vascular access, exposure to infected patients and contaminated equipments etc. Knowledge of the prevalence of such infections is very important to access magnitude of the problem because these infections play important role in the morbidity and mortality of hemodialysis (HD) patients. Aim and Objectives: This study was done to determine the prevalence of Hepatitis B virus (HBV) and Hepatitis C virus (HCV) infections in patients on hemodialysis at our tertiary care hospital of Western Maharashtra. Materials and Methods: Settings and Design: Hospital based cross sectional study was conducted for six months in HD unit at our tertiary care hospital. All patients (n=135) were screened for Hepatitis B surface antigen and antibodies to HCV (anti-HCV). Prevalence, age and sex wise distribution as well as risk factors for transmission of these infections were observed. Results: Total 135 HD patients were screened for presence of HBV and HCV infections. Of these, 39 (28.9%), 20 (14.8%), 6 (4.4%) were found to be having HCV, HBV and Dual HBV and HCV infection respectively. Conclusions: HCV was the most prevalent among HD patients than HBV. History of multiple blood transfusions, HD outside center or longer duration of HD were all important risk factor noted for high prevalence of sero-positivity for HBV and/or HCV. Strict adherence to universal precautions careful attention to hygiene and strict sterilization of dialysis machines are important to prevent further transmission of these viruses.

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Section: Discussioncontrasting

confidence: 59%

Prevalence of asymptomatic hepatitis B virus and hepatitis C virus infections in patients with maintenance hemodialysis of a tertiary care hospital in western Maharashtra

Patil¹,

Munjappa²,

Gadgil³

et al. 2020

IJMR

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“…10 However, this is less than in the intravenous drug users (IDU), 94%. 9 The seroprevalence of Hepatitis C in patients receiving HD in northern and western India 13,14 is reported to be 23% and 2.7% respectively and in Pakistan 15 29.2%. In a systematic review from Middle-East, the highest prevalence was seen in Syria (54%) and Egypt (50%), lowest in Iran (12%) and Lebanon (9%).…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C sero-prevalence and risks of transmission in end-stage renal failure patients undergoing hemodialysis

Manandhar

Acharya²,

Sharma³

et al. 2018

J Patan Acad Health Sci

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Introductions: Hepatitis C virus (HCV) infection is common in the patients undergoing hemodialysis (HD). The quality of life and survival of patients with hepatitis C infected end-stage renal disease is less than that of the noninfected ones. This study aims to determine the prevalence of HCV in patients undergoing HD and the risk of transmission. Methods: This was a retrospective study of charts of the chronic kidney disease patients who underwent dialysis at Patan Hospital from March 2011 to July 2017. Those patients who were positive for HIV, HBsAg and HCV before the initiation of dialysis were excluded. Pearson Chi square test and Fisher’s Exact test were used to determine the significance of the results. Results: Out of 173 patients, 12 (6.9%) seroconverted to HCV: five (41.66%) in first year, four (33.33%) in second year, and three (25%) in third year (Fisher’s Exact test p=0.26). Out of 173 patients, 137 (79.2%) received blood transfusion, 27 (15.6%) received erythropoiesis stimulating agent (ESA), 9 (5.2%) received both blood transfusion and ESA. The HCV seropositivity were 9 (75%), 2 (16.66%), and 1 (8.33%) respectively in them, Fisher’s Exact test p value was 0.65. There was no significant association between the seroconversions in in-center versus multicenter HD and the number of dialyses per week. Conclusions: Hepatitis C infection was common (6.9%) in HD patients. There was no significant association of transmission in regards to duration of HD, transfusion or single vs multicentre HD.

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“…The data presented in Table 4 indicate that during the period from 1993 to 2010, the seroprevalence of HCV in HD patients ranged from 12.1% to 46%, [19][20][21][22][23][24][25] whereas studies conducted after 2010 reveal a general decline in prevalence to 12.4%. [26][27][28][29][30] One exception in this regard, however, is a study conducted in Jammu in 2016, which reported a considerably higher prevalence of 31.4%. 31 We speculate that this wide divergence in prevalence could be attributed to a number of contributory factors, including different geographical locations, a different study duration, or differences in the sensitivity and specificity of the methods used for detecting HCV infection.…”

Section: Seroprevalence Of Hcvmentioning

confidence: 99%

Seroprevalence of Hepatitis C Virus Infection among Hemodialysis Patients in A Tertiary Care Hospital in South India

Rajasekaran¹,

Kalpanaraj²,

Banu³

et al. 2023

J. Pure Appl. Microbiol.

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Hepatitis C virus (HCV) infection in hemodialysis patients is mainly associated with insufficient precautionary measures. Compared with the general population, the prevalence of HCV infection is high among hemodialysis patients. HCV infection in these patients is typically associated with increased morbidity and mortality; however, the early detection of HCV may retard disease progression and reduce morbidity and mortality. In this study, we sought to estimate the seroprevalence of HCV infection among patients undergoing hemodialysis in a tertiary care hospital in Chennai, Tamil Nadu, South India. This was a prospective, observational, cross-sectional study that included 82 hemodialysis patients. Blood samples were collected from each patient, and the serum was separated for detection of the presence of HCV antibodies, HCV core antigen, and HCV RNA using an enzyme-linked immunosorbent assay, enzyme immunoassay, and polymerase chain reaction, respectively. Relevant socio-demographic, clinical, and laboratory information was also obtained. Among samples collected from the 82 patients, seven were found to be positive for HCV antibodies, whereas nine and eleven samples were found to be positive for HCV core antigen and HCV RNA, respectively. Long durations of renal failure and hemodialysis were identified as being positively associated with HCV infection in these hemodialysis patients, and a statistically significant reduction in hemoglobin levels and an increase in creatinine levels were detected among the HCV-positive patients. The overall seroprevalence of HCV infection in hemodialysis patients was found to be 13.4%. Given that high rate false-negative reactions were detected using ELISA and EIA, screening of HCV RNA during the early stages of HCV infection can contribute to preventing its nosocomial spread in these patients. Moreover, it is imperative that stringent universal precautionary measures are implemented in all health care settings and hemodialysis units to minimize the risk of HCV transmission.

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Seroprevalence of hepatitis C in renal failure patients on maintenance hemodialysis - Study in a tertiary care hospital - Western India

Cited by 4 publications

References 9 publications

Prevalence of asymptomatic hepatitis B virus and hepatitis C virus infections in patients with maintenance hemodialysis of a tertiary care hospital in western Maharashtra

Prevalence of asymptomatic hepatitis B virus and hepatitis C virus infections in patients with maintenance hemodialysis of a tertiary care hospital in western Maharashtra

Hepatitis C sero-prevalence and risks of transmission in end-stage renal failure patients undergoing hemodialysis

Seroprevalence of Hepatitis C Virus Infection among Hemodialysis Patients in A Tertiary Care Hospital in South India

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