Seroprevalence of Hepatitis E Virus (HEV) Infection Among Patients Attending BSMMU, Dhaka

Begum, Ayesha; Tabassum, Shahina; Islam, Md. Nazrul; Afzalunnessa,

doi:10.3329/bjmm.v1i2.21509

Cited by 3 publications

(6 citation statements)

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“…Among pregnant women living in rural areas, the HEV infection rate is 46 cases/per 1000 person-year [ 56 ]. A prevalence survey among patients admitted to hospitals with hepatitis showed HEV caused 35% of sporadic acute hepatitis [ 57 ] and 22% of acute-on-chronic liver disease in Dhaka in 2008 [ 58 ]. An earlier survey from 2004 to 2006 identified HEV as the cause for 58% of general patients, 45% of pregnant patients with acute hepatitis, and 56% of cases with hepatic failure in Dhaka [ 19 ].…”

Section: Epidemiologymentioning

confidence: 99%

Hepatitis E Virus (HEV) Synopsis: General Aspects and Focus on Bangladesh

Aziz

Øverbø

Julin

et al. 2022

Viruses

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HEV is the most common cause of acute hepatitis globally. This review summarizes the latest knowledge on the epidemiology, clinical characteristics, testing, and treatment of HEV infection. We also focused on Bangladesh to highlight the distinct challenges and the possible remedies. In low-income settings, the virus is mainly transmitted between people by fecal contamination of drinking water causing large outbreaks, and sporadic cases. The disease is usually mild and self-limiting acute hepatitis. Still, pregnant women and their offspring in low-income countries are at particular risk for severe disease, with up to 20% maternal mortality. Despite the high burden of the disease, HEV remains a relatively neglected virus, with detection hampered by costly tests and a lack of suitable treatments. Molecular PCR diagnostics, together with ELISA antibody tests, remain the preferred methods for diagnosis of HEV; however, rapid bedside diagnostics are available and could offer a practical alternative, especially in low-income countries. One vaccine (HEV 239) is only available in China and Pakistan, as efficacy against the other genotypes remains uncertain. The effectiveness trial conducted in Bangladesh might lead the way in gathering more efficacy data and could, together with improved surveillance and raised awareness, dramatically reduce the global burden of HEV.

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Section: Epidemiologymentioning

confidence: 99%

Hepatitis E Virus (HEV) Synopsis: General Aspects and Focus on Bangladesh

Aziz

Øverbø

Julin

et al. 2022

Viruses

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“…19 A small proportion of subjects of many industrialized countries found to have circulatory antibodies to HEV, while in Bangladesh which is endemic for HEV and where seroprevalence rate of anti-HEV IgG antibodies are higher though considerable variations have been observed in other studies in Bangladesh. 20,7 In our study, seroprevalence of anti-HEV IgG on pregnant women demonstrates the high prevalence (37.6%), a considerable potential for the transmission of HEV infection in pregnant women. In one study from rural area Matlab, Chandpur reported lower anti-HEV positivity rates (22.5%, 255 out of 1134) in asymptomatic healthy subjects and another study from BSMMU, Dhaka also reported nearly same prevalence (20.6%) of anti-HEV IgG in people of The overall seroprevalence of HEV infection among pregnant women in Bangladesh is higher than the results of other studies done in Ghana (28.66%) 23 , India (33.67%) 19 , United Arab Emirates (20%) 24 , Gabon (14.1%) 25 , but lower than that in Egypt (84.3%) 26 , Ethiopia (59%) 27 , and Sudan (41.1%) 28 .…”

Section: Discussionmentioning

confidence: 99%

“…It causes epidemics, especially in developing countries where sanitation and hygienic practices are poor and drinking water supplies are often contaminated by sewage. 20 Pregnant women are at increased risk of contracting acute HEV infection that often leads to acute liver failure. 21 A study done at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka on 31 pregnant women indicated HEV as a principal etiological agent (45.16%) for acute hepatitis, the fatality for which approaches >75% when the infection occurs in the second/ third trimester of pregnancy with fulminant hepatic failure.…”

Section: Discussionmentioning

confidence: 99%

“…A few studies on seroprevalence of HEV IgG among general population are available in Bangladesh, 7,20 there is a lack of data with respect to Bangladeshi pregnant women. The present study was carried out to determine the seroprevalence of subclinical HEV infection in healthy pregnant women attending urban centers of the Health Care Development Project under Diabetic Association of Bangladesh.…”

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Seroprevalence of Subclinical HEV Infection in Healthy Pregnant Urban Dwellers of Bangladesh: Identification of Possible Risk Factors

et al. 2018

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“…Bangladesh has a high HEV burden, where small outbreaks are common. The prevalence of HEV antibody among the general population is 22%-60% [20][21][22]; the incidence of HEV seroconversion is 40 per 1,000 people per year in rural settings [21]. Drinking municipal tap water, outdoor employment, recent urban travel, and recent contact with a patient with jaundice have been identified as HEV infection risk factors [21,23].…”

Section: Plos Onementioning

confidence: 99%

A tightly clustered hepatitis E virus genotype 1a is associated with endemic and outbreak infections in Bangladesh

et al. 2021

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Background Hepatitis E virus (HEV) infection is endemic in Bangladesh and there are occasional outbreaks. The molecular characteristics and pathogenesis of endemic and outbreak HEV strains are poorly understood. We compared the genetic relatedness and virulence associated mutations of endemic HEV strains with outbreak strains. Methods We analyzed systematically collected serum samples from HEV immunoglobulin M (IgM) positive patients attended at Bangabandhu Sheikh Mujib Medical University, Dhaka from August 2013 to June 2015. HEV RNA positive samples were subjected to whole genome sequencing. Genotype and subtype of the strains were determined by phylogenetic analysis. Virulence associated mutations e.g. acute viral hepatitis (AVH), fulminant hepatic failure (FHF), chronic hepatitis, ribavirin treatment failure (RTF), B and T cell neutralization epitopes were determined. Results 92 HEV immunoglobulin M (IgM) antibody positive plasma samples (43 in 2013–2014 and 49 in 2014–2015) were studied. 77.1% (70/92) of the samples were HEV RNA positive. A 279 bp open reading frame (ORF) 2 and ORF 3 sequence was obtained from 54.2% (38/70) of the strains. Of these 38 strains, whole genome sequence (WGS) was obtained from 21 strains. In phylogenetic analysis of 38 (279 bp) sequence all HEV sequences belonged to genotype 1 and subtype 1a. Further phylogenetic analysis of 21 HEV WGS, Bangladeshi HEV sequences clustered with genotype 1a sequences from neighboring countries. Within genotype 1a cluster, Bangladesh HEV strains formed a separate cluster with the 2010 HEV outbreak strains from northern Bangladesh. 80.9 to 100% of the strains had A317T, T735I, L1120I, L1110F, P259S, V1479I, G1634K mutations associates AVH, FHF and RTF. Mutations in T cell recognition epitope T3, T5, T7 was observed in 76.1%, 100% and 100% of the strains respectively. Conclusion Strains of HEV genotype 1a are dominant in Bangladesh and are associated with endemic and outbreak of HEV infection. HEV isolates in Bangladesh have high prevalence of virulence associated mutations and mutation which alters antigenicity to B and T cell epitopes.

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Seroprevalence of Hepatitis E Virus (HEV) Infection Among Patients Attending BSMMU, Dhaka

Abstract: The present study was done to determine the seroprevalence of the infection by Hepatitis E virus (

Cited by 3 publications

References 7 publications

Hepatitis E Virus (HEV) Synopsis: General Aspects and Focus on Bangladesh

Hepatitis E Virus (HEV) Synopsis: General Aspects and Focus on Bangladesh

Seroprevalence of Subclinical HEV Infection in Healthy Pregnant Urban Dwellers of Bangladesh: Identification of Possible Risk Factors

A tightly clustered hepatitis E virus genotype 1a is associated with endemic and outbreak infections in Bangladesh

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