Seroprevalence of hepatitis E virus in patients with chronic liver disease

de Araújo, Lílian Rose Maia Gomes; Batista, Andrea Dória; Côelho, Maria Rosângela Cunha Duarte; Santos, Joelma Carvalho; Cunha, Gabriel Galindo; Leal, Gabriela Rodrigues Aguiar; Pinho, João Renato Rebello; Domingues, Ana Lúcia Coutinho; Lopes, Edmundo Pessoa

doi:10.1007/s42770-023-01197-7

Cited by 2 publications

(2 citation statements)

References 28 publications

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“… 181 In 2023, Brazilian scientists announced 3.08% anti-HEV IgG positive results in 227 individuals with chronic liver disease (alcohol-related liver disease – 17 individuals; HBV – 50; HCV – 33; mixed disease – 62; NAFLD – 49; and schistosomiasis – 16). 182 …”

Section: Hev Among Individuals With Chronic Liver Diseasementioning

confidence: 99%

“…181 In 2023, Brazilian scientists announced 3.08% anti-HEV IgG positive results in 227 individuals with chronic liver disease (alcohol-related liver disease -17 individuals; HBV -50; HCV -33; mixed disease -62; NAFLD -49; and schistosomiasis -16). 182 A brief review of the scientific literature showed that HEV infection can occur and may be more frequent among individuals with underlying chronic liver disease. HEV-related complications and mortality could be observed more often in this population.…”

Section: Hev Among Rheumatic Diseases Patientsmentioning

confidence: 99%

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Hepatitis E Virus (HEV) Infection Among Immunocompromised Individuals: A Brief Narrative Review

Alexandrova,

Tsachev,

Kirov

et al. 2024

IDR

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Hepatitis E virus (HEV) is a single-stranded positive-sense RNA virus that belongs to Hepeviridae family. HEV is the most common cause of acute viral hepatitis worldwide. According to the World Health Organization (WHO), there are estimated 20 million HEV infections worldwide every year, leading to estimated 3.3 million symptomatic cases of HEV infection. The WHO estimates that HEV infection caused approximately 44,000 deaths in 2015, which represents 3.3% of mortality rates due to viral hepatitis. In low-income (LI) countries and lower-middle-income (LMI) countries, HEV is a waterborne infection induced by HEV genotype (gt) 1 and HEV gt 2 that cause large outbreaks and affect young individuals with a high mortality rate in pregnant women from South Asian countries and patients with liver diseases. HEV gt 3, HEV gt 4, and HEV gt 7 are responsible for sporadic infections with zoonotic transmission mainly through the consumption of raw or undercooked meat from different animals. Acute HEV infection is relatively asymptomatic or mild clinical form, in rare cases the disease can be moderate/severe clinical forms and result in fulminant hepatitis or acute liver failure (ALF). Furthermore, HEV infection is associated with extrahepatic manifestations, including renal and neurological clinical signs and symptoms. Pregnant women, infants, older people, immunocompromised individuals, patients with comorbidities, and workers who come into close contact with HEV-infected animals are recognized as major risk groups for severe clinical form of HEV infection and fatal outcome. Chronic HEV infection can occur in immunocompromised individuals with the possibility of progression to cirrhosis.

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Section: Hev Among Individuals With Chronic Liver Diseasementioning

confidence: 99%

Section: Hev Among Rheumatic Diseases Patientsmentioning

confidence: 99%

Hepatitis E Virus (HEV) Infection Among Immunocompromised Individuals: A Brief Narrative Review

Alexandrova,

Tsachev,

Kirov

et al. 2024

IDR

View full text Add to dashboard Cite

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Seroprevalence of Hepatitis E Virus Among Schistosomiasis mansoni Patients Residing in Endemic Zone in Brazil

Gomes,

Mariz,

Batista

et al. 2024

TropicalMed

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The occurrence of hepatitis E virus (HEV) in patients with Schistosomiasis mansoni (SM) is still poorly understood in Brazil. The objective of this study was to estimate the seroprevalence of anti-HEV IgG in patients with SM and its association with the periportal fibrosis (PPF), assessed by serum markers and ultrasound criteria. This cross-sectional study was carried out in an endemic area in Pernambuco, Brazil, with schistosomal patients who underwent coproscopic survey. Anti-HEV antibody IgG were evaluated by using ELISA (Euroimmun®, Lübeck, Germmany). In positive cases, HEV-RNA was tested by using real-time PCR. Among the 286 patients (60.8% women; 56% 18–44 years), 116 (40.6%) had advanced PPF (Niamey pattern D/E/F). Anti-HEV IgG was positive in 15 (5.24%), and all were HEV-RNA negative. Anti-HEV IgG was more frequent in patients with an advanced PPF (D/E/F) pattern (p = 0.034) and those with the largest spleen diameter (p = 0.039). In this study, the occurrence of anti-HEV IgG in patients with SM was higher than described in the same region and more frequent among patients with evidence of advanced liver fibrosis.

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Seroprevalence of hepatitis E virus in patients with chronic liver disease

Cited by 2 publications

References 28 publications

Hepatitis E Virus (HEV) Infection Among Immunocompromised Individuals: A Brief Narrative Review

Hepatitis E Virus (HEV) Infection Among Immunocompromised Individuals: A Brief Narrative Review

Seroprevalence of Hepatitis E Virus Among Schistosomiasis mansoni Patients Residing in Endemic Zone in Brazil

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