Seroprevalence of Hepatitis Viruses B, C, D and HIV Infection Among Hemodialysis Patients in Kerman Province, South-East Iran

Abstract

BackgroundThe prevalence of hepatitis viruses in hemodialysis patients has been reported to be much greater than in the general population. Attention to local data, effectively guides health planners so that they can control infections and prevent nosocomial transmissions.ObjectivesThis cross sectional study was carried out to determine the prevalence of hepatitis B (HBV), hepatitis C (HCV), and hepatitis D (HDV) viruses, as well as the human immunodeficiency virus (HIV) in dialysis centers in the Kerman Province, in the southeast of Iran.Patients and MethodsAll hemodialysis patients (n = 228) in 7 centers were enrolled in the study. Hepatitis B surface antigens (HBsAg), HCV antibodies (Ab), HDV Ab and HIV Ab were measured using specific enzyme linked immunoassay kits (ULTRA kit, bioMérieux, France) and confirmed by a qualitative PCR assay.ResultsThe studied group was comprised of 92 (40.4%) females and 136 (59.6%) males. The mean age of the patients was 51 ± 9.5 years and the duration of hemodialysis was 39.7 ± 7.9 months. Positive HBsAg was found in 7% of cases, HCV Ab in 7%, and patients with both viruses were detected in 1.7% cases. HIV Ab and HDV Ab were negative in all cases. Out of the other risk factors, frequency of blood transfusions was significantly correlated with positive HCV Ab (P < 0.008).ConclusionsPrevalence of HBV and HCV in hemodialysis patients was moderate to low in the Kerman Province, as in other parts of the country. Strict adherence to protective measures could lead to even lower rates.

Prevalence and Risk Factors of Hepatitis B and Hepatitis C Virus Infections among Patients with Chronic Renal Failure in Zabeed City, Yemen Republic

“…On the other hand, 14 Studies carried out in various centers worldwide among dialysis patients have shown a prevalence of HCV as 8% -36% in North America, [16] 25% -39% in South America, [17] 1% -36% in Europe, [18] 17% -51% in Asia, [4] 1.2% -10% in New Zealand and Australia, [4] [16] and 7% -85% in South Africa [2] have reported that among patients on hemodialysis 5.9% were HCV positive while, 1.4% patients had HBV infection and 3.7% had infection with HBV and HCV [12]. Chandra et al have reported that among the patients of chronic kidney disease, renal transplant orhemodialysis, HBV, HCV and infection of both viruses were 7.46% and 37.10% respectively these results are not agreement to the results of our study [19].…”

Prevalence, Seroconversion and Risk Factors of Hepatitis B and C Infection in Patients on Maintenance Hemodialysis

“…17 This observation was in agreement with previous reports in Palestine, Moldavia, and other studies from different regions of the world. [20][21][22][23] Duration of dialysis is an important risk factor for acquiring infections as it is related to nosocomial transmission and dissemination of the infections in the dialysis units. 17 While analyzing patients who seroconverted, number of blood transfusions received significantly contributed to development of either hepatitis B or C infection in our study.…”

Liver transplantation in a patient with hepatitis B, C and D coinfection associated with hepatocellular carcinoma: a management strategy for a rare condition. Case report

“…[15][16][17][18][19] Seroprevalence studies on triple hepatitis virus infections usually involve blood donors or patients with chronic liver diseases, but these do not represent the whole population. [15][16][17][18][19] In the state of Acre in Brazil, the seroprevalence rates for HBV and HDV are approximately 3.4% and 1.7%, respectively. 20 The biomolecular prevalence of HCV RNA within the population is estimated as 2.5%, and 0.05% of the same population will express concomitant markers, namely HCV RNA, HBsAg and antibodies against HDV.…”