Seroprevalence of Human Herpesvirus 6 Infection in Brazilian and Japanese Populations in the North‐East of Brazil

Linhares, Maria Ieda Siqueira; Eizuru, Yoshito; Tateno, Seiki; Minamishima, Yoichi

doi:10.1111/j.1348-0421.1991.tb01624.x

Cited by 21 publications

(15 citation statements)

References 30 publications

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“…It is well known that erythematous rashes occur in many common viral infections, like arboviruses, infectious mononucleosis, enteroviruses and the more recently described human herpesvirus 6 (HHV-6). Preliminary studies of HHV-6 infection in north-east Brazil detected seroprevalence rates of 70% and children were found to possess high level of antibodies 15 . So the etiology of these cases remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Human parvovirus B19 infections among exanthematic diseases notified as measles

Cubel

Siqueira²,

Santos³

et al. 1997

Rev. Soc. Bras. Med. Trop.

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A total of 1397 sera collected from 1095 cases of exanthematic disease notified as measles in ES and RJ states during July 1992 to December 1994 were investigated. These sera were first tested for measles and rubella specific IgM. When they proved negative, they were tested for B19 specific IgM by an enzyme immunoassay. B19 infection was confirmed in 27 (2.5%) of these cases. Sera from 194 negative cases for measles and rubella IgM received from other Brazilian states were also investigated and B19 infection was confirmed for 11 of them. Sera from these 38 IgM positive cases for B19, were tested for anti-B19 IgG by an enzyme immunoassay and for B19 DNA by dot blot hybridization. Anti-B19 IgG antibodies were detected in most of the acute sera. B19 DNA was detected in the acute serum of one patient that had been splenectomized before. As the exanthem caused by human parvovirus infection may be clinically diagnosed as rubella, it could be important to diagnose B19 infection in Brazil since it is becoming prevalent as the cause of rash in countries where rubella is controlled by vaccination.
Um total de 1397 soros colhidos de 1095 casos de exantema notificados como sarampo, nos estados do ES e RJ, no período de julho de 1992 a dezembro de 1994, foram investigados. Estes soros foram inicialmente testados para sarampo e rubéola por detecção de IgM específica. Os casos negativos foram então testados para a presença de IgM específca anti-B19 por um ensaio imunoenzimático. A infecção pelo B19 foi confirmada em 27 (2,5%) destes casos. Soros de 194 casos negativos para sarampo e rubéola provenientes de outros estados brasileiros foram também investigados, e a infecção pelo B19 pode ser confirmada em 11 destes casos. Os soros dos 38 casos IgM positivos para B19 foram testados para a presença de IgG específica anti-B19 por um ensaio imunoenzimático, e para a presença do ADN viral por hibridização em "dots" (dot blot). IgG específica anti-B19 pode ser detectada na maioria dos soros de fase aguda, e o ADN viral foi detectado no soro de fase aguda de um paciente esplenectomizado. Como o exantema causado pela infecção pelo parvovírus humano pode ser clinicamente diagnosticado como rubéola, seria importante realizar o diagnóstico desta virose no Brasil, já que um aumento no número de casos de exantema por B19 tem sido relatado nos países onde a rubéola é controlada por vacinação

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Section: Discussionmentioning

confidence: 99%

Human parvovirus B19 infections among exanthematic diseases notified as measles

Cubel

Siqueira²,

Santos³

et al. 1997

Rev. Soc. Bras. Med. Trop.

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“…Nevertheless, the seropositivity in the adult population is now estimated to be Ͼ95% for either or both HHV-6 variants in developed countries, the antibody titers showing a decline with advancing age (27,175,322,354). HHV-6 is widespread throughout the world, with geographic differences in HHV-6 prevalence varying between 70 and 100% (36,69,240,306,409,432); given the above-mentioned limitations, these differences may be insignificant. A serologic test discriminating between HHV-6 variants is not available.…”

Section: Clinical Features Of Hhv-6 Epidemiologymentioning

confidence: 99%

Update on Human Herpesvirus 6 Biology, Clinical Features, and Therapy

2005

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Human herpesvirus 6 (HHV-6) is a betaherpesvirus that is closely related to human cytomegalovirus. It was discovered in 1986, and HHV-6 literature has expanded considerably in the past 10 years. We here present an up-to-date and complete overview of the recent developments concerning HHV-6 biological features, clinical associations, and therapeutic approaches. HHV-6 gene expression regulation and gene products have been systematically characterized, and the multiple interactions between HHV-6 and the host immune system have been explored. Moreover, the discovery of the cellular receptor for HHV-6, CD46, has shed a new light on HHV-6 cell tropism. Furthermore, the in vitro interactions between HHV-6 and other viruses, particularly human immunodeficiency virus, and their relevance for the in vivo situation are discussed, as well as the transactivating capacities of several HHV-6 proteins. The insight into the clinical spectrum of HHV-6 is still evolving and, apart from being recognized as a major pathogen in transplant recipients (as exemplified by the rising number of prospective clinical studies), its role in central nervous system disease has become increasingly apparent. Finally, we present an overview of therapeutic options for HHV-6 therapy (including modes of action and resistance mechanisms)

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“…The first studies dealing with HHV-6 infection in Brazil were carried out by LINHARES et al 33 , who recorded seroprevalence rates of 76.5% and 77.2% in Brazilian and Japanese immigrants, respectively, in the north-eastern region. Subsequent serosurvey studies conducted in the Amazon region of Brazil yielded prevalence rates of HHV-6 antibody that ranged from 5.4% to 14.9%, among amerindians 16 , and from 75% to 100% in the urban communities 17 .…”

Section: Introductionmentioning

confidence: 99%

Outbreaks of human-herpes virus 6 (HHV-6) infection in day-care centers in Belém, Pará, Brazil

Freitas

Monteiro

Linhares

2000

Rev. Inst. Med. trop. S. Paulo

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SUMMARYA total of 730 children aged less than 7 years, attending 8 day-care centers (DCCs) in Belém, Brazil were followed-up from January to December 1997 to investigate the occurrence of human-herpes virus 6 (HHV-6) infection in these institutional settings. Between October and December 1997 there have been outbreaks of a febrile-and -exanthematous disease, affecting at least 15-20% of children in each of the DCCs. Both serum-and-plasma samples were obtained from 401 (55%) of the 730 participating children for the detection of HHV-6 antibodies by enzyme-linked immunosorbent assay (ELISA), and viral DNA amplification through the nested-PCR. Recent HHV-6 infection was diagnosed in 63.8% (256/401) of them, as defined by the presence of both IgM and IgGspecific antibodies (IgM+/IgG+); of these, 114 (44.5%) were symptomatic and 142 (55.5%) had no symptoms (p = 0.03). A subgroup of 123 (30.7%) children were found to be IgM-/IgG+, whereas the remaining 22 (5.5%) children had neither IgM nor IgG HHV-6-antibodies (IgM-/IgG-). Of the 118 children reacting strongly IgM-positive (³ 30 PANBIO units), 26 (22.0%) were found to harbour the HHV-6 DNA, as demonstrated by nested-PCR. Taken the ELISA-IgM-and-nested PCR-positive results together, HHV-6 infection was shown to have occurred in 5 of the 8 DCCs under follow-up. Serological evidence of recent infections by Epstein-Barr virus (EBV) and parvovirus B19 were identified in 2.0% (8/401) and 1.5% (6/401) of the children, respectively. Our data provide strong evidence that HHV-6 is a common cause of outbreaks of febrile/exanthematous diseases among children attending DCCs in the Belém area.

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Seroprevalence of Human Herpesvirus 6 Infection in Brazilian and Japanese Populations in the North‐East of Brazil

Cited by 21 publications

References 30 publications

Human parvovirus B19 infections among exanthematic diseases notified as measles

Human parvovirus B19 infections among exanthematic diseases notified as measles

Update on Human Herpesvirus 6 Biology, Clinical Features, and Therapy

Outbreaks of human-herpes virus 6 (HHV-6) infection in day-care centers in Belém, Pará, Brazil

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