Seroprevalence of Human Herpesvirus 8 and Its Association With Kaposi Sarcoma in Brazil

Zago, Adriana Marchon; Bourboulia, Dimitra; Viana, Maria Carmen; Collandre, Hélène; Dietze, Reynaldo; Boshoff, Chris; Keller, Regina

doi:10.1097/00007435-200009000-00009

Cited by 32 publications

(34 citation statements)

References 23 publications

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“…In blood donors from Brazilian southern states a 4.6% prevalence has been reported [Zago et al, 2000]. The latter is similar to our finding of 2.8% (95% CI 1.0-4.6) in Campinas, Sã o Paulo.…”

Section: Discussionsupporting

confidence: 91%

Seroprevalence of human herpesvirus‐8 in blood donors from different geographical regions of Argentina, Brazil, and Chile

Perez

Tous

Gallego

et al. 2004

Journal of Medical Virology

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Human herpesvirus-8 (HHV-8) causes Kaposi's sarcoma (KS) and lymphoproliferative disorders in both HIV-infected and uninfected patients. HHV-8 has a worldwide occurrence but infection rates vary according to a combination of geographic and behavioral risks. The main transmission route seems to be sexual, nevertheless, nasal secretions, saliva, blood, and organ graft have been proposed. HHV-8 was postulated as a new infectious agent for screening in blood donors. The aim of this study was to evaluate the prevalence of antibodies against HHV-8 antigens in blood donors of South America. Serum samples from 2,470 blood donors from Argentina, Brazil, and Chile corresponding to five geographic regions were studied by indirect immunofluorescence assay (IFA). Seroprevalence rate was 3.7% (92/2,470; 95% CI 2.9-4.5) in the entire blood donor population distributed as follows: Argentina, 4.0% (Buenos Aires city, 4.3%; Bahia Blanca, 2.4%; and Córdoba, 4.0%), Campinas (Brazil), 2.8%; and Santiago de Chile, 3.0%. There was no difference (P>0.05) between men and women or age related, except in Brazil where positive cases were 30-49-year-old males. The present study, which includes different geographical areas of multiple countries from South America, has not been done before. The results show similar prevalence rates among the studied zones corresponding to low-prevalence regions. South America is a large sub-continent with a wide spectrum of population and geographical characteristics, thus, more HHV-8 prevalence studies should be necessary to establish possible regional differences.

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Section: Discussionsupporting

confidence: 91%

Seroprevalence of human herpesvirus‐8 in blood donors from different geographical regions of Argentina, Brazil, and Chile

Perez

Tous

Gallego

et al. 2004

Journal of Medical Virology

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“…There are few studies regarding the prevalence of HHV-8 infection. Among blood donors, seroprevalence rates of 4.6 and 7.4% were found in Vitória and São Paulo, respectively (14,15). Among HIV patients without KS, the seroprevalence rates observed in these two studies were 16 and 18.5%, respectively.…”

mentioning

confidence: 73%

Prevalence of antibodies to human herpesvirus-8 in populations with and without risk for infection in São Paulo State

Souza

Sumita

Freire

et al. 2004

Braz J Med Biol Res

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Human herpesvirus 8 (HHV-8) is a newly described herpesvirus that is etiologically associated with all forms of Kaposi's sarcoma (KS). Seroepidemiological studies have shown high prevalence rates of HHV-8 antibodies among men who have sex with men (MSM) and AIDS patients, African children, Brazilian Amerindians, and elderly individuals in certain regions of Europe. The aim of the present study was to determine the prevalence of HHV-8 antibodies in healthy children and young adults from different cities in São Paulo State, and in a population at high risk for HHV-8 infection: HIV-negative MSM, and AIDS patients with and without KS. Antibodies to HHV-8 latency-associated nuclear antigen and lytic-phase antigens were detected by immunofluorescence assays. In 643 healthy children and young adults from the general population attending a vaccination program for yellow fever in ten different cities in São Paulo State, the prevalence of HHV-8 antibodies detected by the presence of latent or lytic antigens ranged from 1.0 to 4.1% in the different age groups (mean = 2.5%). In the MSM group, the prevalence was 31/95 (32.6%). In the group of patients with AIDS, the prevalence was 39.2% (51/130) for non-KS patients and 98.7% (77/78) for AIDS patients with the diagnosis of KS confirmed by histopathological examination. We conclude that HHV-8 has a restricted circulation among healthy children and young adults in the general population of São Paulo State and a high prevalence among MSM and AIDS patients.

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“…Studies regarding its presence in Brazil disclosed HHV-8 endemic populations among Amerindians and homosexual/bisexual men infected with HIV-1 [2][3][4][5][6][7][8].…”

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confidence: 99%

Latent human herpesvirus - 8 (HHV-8) infection in female commercial sex workers from Imbituba, Santa Catarina, Brazil

et al. 2007

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Human herpesvirus 8 (HHV-8) infection was identified in 6 out of 90 (6.7%) female commercial sex workers from Imbituba, Santa Catarina, and was associated to age. Frequencies of 5.6% of anti-latent and 3.3% of anti-lytic antibodies were detected. Considering non-endemic areas from Brazil, the anti-latent antibodies frequency seems elevated and requires further investigation on referent female population.

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Seroprevalence of Human Herpesvirus 8 and Its Association With Kaposi Sarcoma in Brazil

Cited by 32 publications

References 23 publications

Seroprevalence of human herpesvirus‐8 in blood donors from different geographical regions of Argentina, Brazil, and Chile

Seroprevalence of human herpesvirus‐8 in blood donors from different geographical regions of Argentina, Brazil, and Chile

Prevalence of antibodies to human herpesvirus-8 in populations with and without risk for infection in São Paulo State

Latent human herpesvirus - 8 (HHV-8) infection in female commercial sex workers from Imbituba, Santa Catarina, Brazil

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