Seroprevalence of human immunodeficiency virus among blood donors in Northwest Ethiopia, 1995-2002

Kassu, Afework; Moges, Feleke; Mekonnen, Firew; Mengistu, Getahun; Abate, Ebba; Mekonnen, Endris; Molla, Kassie; Zewde, T.; Aseffa, Abraham; Wondmikun, Yared; Ota, Fusao

doi:10.1258/004947506776593567

Cited by 8 publications

(8 citation statements)

References 6 publications

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“…This finding is consistent with the observed declining trend of HIV seroprevalence in the general population in Ethiopia [11], declining trend of HIV prevalence among blood donors in Ethiopia [12], declining trend of HIV prevalence among pregnant women, and declining trend of syphilis infections among pregnant women in Addis Ababa [13]. The initial rise in HIV seroprevalence among the blood donors represents the peak of the epidemic when denial was prevalent and little attention was paid to the disease.…”

Section: Discussionsupporting

confidence: 91%

Seroprevalence of HIV, HBV, HCV and syphilis infections among blood donors at Gondar University Teaching Hospital, Northwest Ethiopia: declining trends over a period of five years

et al. 2010

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Background: Transfusion-transmissible infectious agents such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis are among the greatest threats to blood safety for the recipient. This study aimed to determine the seroprevalence, risk factors and trends of HIV, HBV, HCV and syphilis infections among blood donors over a period of five years at Gondar University Teaching Hospital, Northwest Ethiopia. Methods: A retrospective analysis of consecutive blood donors' records covering the period between January 2003 and December 2007 was conducted. Logistic regression analysis was used to determine risk factors associated with HIV, HBV, HCV and syphilis infections.Results: From the total of 6361 consecutive blood donors, 607 (9.5%) had serological evidence of infection with at least one pathogen and 50 (0.8%) had multiple infections. The overall seroprevalence of HIV, HBV, HCV and syphilis was 3.8%, 4.7%, 0.7%, and 1.3% respectively. Among those with multiple infections, the most common combinations were HIV -syphilis 19 (38%) and HIV -HBV 17 (34%). The seropositivity of HIV was significantly increased among female blood donors, first time donors, housewives, merchants, soldiers, drivers and construction workers. Significantly increased HBV seropositivity was observed among farmers, first time donors and age groups of 26 -35 and 36 -45 years. Similarly, the seroprevalence of syphilis was significantly increased among daily labourers and construction workers. Statistically significant association was observed between syphilis and HIV infections, and HCV and HIV infections. Moreover, significantly declining trends of HIV, HCV and syphilis seropositivity were observed over the study period. Conclusions: A substantial percentage of the blood donors harbour HIV, HBV, HCV and syphilis infections. Strict selection of blood donors and comprehensive screening of donors' blood using standard methods are highly recommended to ensure the safety of blood for recipient.

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Section: Discussionsupporting

confidence: 91%

Seroprevalence of HIV, HBV, HCV and syphilis infections among blood donors at Gondar University Teaching Hospital, Northwest Ethiopia: declining trends over a period of five years

et al. 2010

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“…In the recent survey in Central, Western and Eastern francophone Africa regions, all seven countries surveyed reported less than 30% females in their donor population (Tayou Tagny et al ., 2009). Other reports from Anglophone East and Southern African countries have also shown a male dominance in blood donation programmes (Kassu et al ., 2006; Cunha et al ., 2007). According to Cunha et al .…”

Section: Donor Gendermentioning

confidence: 83%

“…In South Africa and Central Africa Republic, it was, respectively, 0·10 and 15% in new donors in 2004 (Tapko et al ., 2007), but its mean is frequently approximately 3–5% among new blood donors: 2·9% in Cameroon in 2005 (Mbanya & Tayou, 2005), 4·9% in Malawi (Tapko et al ., 2007) and 4·3% in Ethiopia in 2002 (Kassu et al ., 2006). It is clearly demonstrated that the prevalence of blood transmissible viruses is dependent on the type of blood donor; voluntary donors have lower prevalence (Mbanya & Tayou, 2005; Kassu et al ., 2006; WHO, 2004a). Amongst paid commercial blood donors, HIV prevalence as high as 10% has been reported for instance in Nigeria by Umolu et al ., 2005.…”

Section: Ttis and Blood Donormentioning

confidence: 99%

The blood donor in sub-Saharan Africa: a review

Tagny

Owusu‐Ofori

Mbanya

et al. 2010

Transfusion Medicine

126

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The high prevalence of numerous endemic and epidemic diseases such as malaria, HIV infection and viral hepatitis in some areas of sub-Saharan Africa (SSA) affects the health status of blood donors. Considering the difficulties in ensuring sufficient and safe blood supply, analysing epidemiological factors that impact blood donors in this community may further bring light on issues of supply and safety, and help in planning for its rational use. This review does not aim to propose new strategies but describes the main characteristics of blood donors in SSA as collected from different reports. Data were mainly obtained from the reports of the World Health Organization and national blood transfusion programmes and also from relevant literature and conference reports. Several characteristics are common in blood donors, such as the predominance of young adult males, the high frequency of Transmission-transmitted Infections (TTIs) and some erythrocytic phenotypes. The data indicate variations in the level of improvement of blood collection and blood safety from one area to another, particularly in the field of donor motivation or screening strategies for TTIs. These data could be useful to supplement previous reports and to provide updates for governments and international organizations' programs involved in the improvement of blood safety in Africa.

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“…On the other hand, significantly declining fashion of HIV seroprevalence were observed in the studies done in blood banks of Jimma University Specialized Hospital and Gonder University hospital 7 , 8 and NorthWest Ethiopia. 9 The Federal Ministry of Health reported the National HIV prevalence as 3.5% and 5% among blood donors in 2005 where the prevalence for those blood donors in the age group 15–19 years was 2.9% but the highest prevalence occurred among donors in the age group of 30–39 years. 10…”

Section: Introductionmentioning

confidence: 99%

HIV-Sero- prevalence trend among blood donors in North East Ethiopia

et al. 2017

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BackgroundAlthough blood transfusion is one of the known therapeutic interventions that cuts across a number of clinical disciplines. It is necessary to test all intending blood donors for HIV infection before donation. The aim of this study was to determine the prevalence of HIV among blood donors at Dessie Blood Bank, Northeast Ethiopia.MethodsA retrospective study was conducted in Dessie Blood Bank through the year 2008–2012. Sera from blood donors were tested for the detection of Anti HIV by using 4th generation ELISA. Data were abstracted from records and analyzed using Microsoft Excel sheet.ResultsFrom the total of 9384 screened blood samples collected, the prevalence of HIV in blood donors in the blood bank was 5.1% in the five consecutive years but the trend of HIV infection has decreased from 2008(5.2%) to 2012 (2.3%). The age groups 15–24 and 35–44 were the highest prevalence and the age group 45–54 was the lowest prevalence of HIV infection. The prevalence of HIV among female (7.9%) was higher than in male donors (4.4%). The trend of HIV infection was decreasing for both male and female blood donors.ConclusionThe prevalence of HIV infections among blood donors is still high in this study setting, and needs constant monitoring to evaluate prevention and control strategies to reduce the burden of transfusion-transmissible HIV infections.

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Seroprevalence of human immunodeficiency virus among blood donors in Northwest Ethiopia, 1995-2002

Cited by 8 publications

References 6 publications

Seroprevalence of HIV, HBV, HCV and syphilis infections among blood donors at Gondar University Teaching Hospital, Northwest Ethiopia: declining trends over a period of five years

Seroprevalence of HIV, HBV, HCV and syphilis infections among blood donors at Gondar University Teaching Hospital, Northwest Ethiopia: declining trends over a period of five years

The blood donor in sub-Saharan Africa: a review

HIV-Sero- prevalence trend among blood donors in North East Ethiopia

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