Seroprevalence of human metapneumovirus in Japan

Ebihara, Takashi; Endo, Rika; Kikuta, Hídeaki; Ishiguro, Nobuhisa; Yoshioka, Masaharu; Ma, Xiaoming; Kobayashi, Kunihiko

doi:10.1002/jmv.10391

Cited by 131 publications

(137 citation statements)

References 10 publications

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“…Nearly all children have serologic evidence of infection by 5 y of age (1,32). van den Hoogen et al (1) originally found no hMPV in 400 samples obtained from asymptomatic children, whereas a group led by Williams tested 86 samples from asymptomatic children found only one positive sample for hMPV (1%) (2).…”

Section: Human Metapneumovirusmentioning

confidence: 99%

Human Metapneumovirus and Human Bocavirus in Children

Milder

Arnold

2009

Pediatr Res

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Several new viruses have recently been described in children, including human metapneumovirus (hMPV) and human bocavirus (HBoV). hMPV has been established as a common cause of upper and lower respiratory tract infections in children, often second only to respiratory syncytial virus as a cause of bronchiolitis in infants. Diagnostic tools have been developed for the clinician and effective treatment and prevention strategies are being investigated. HBoV was more recently identified. Although it was initially identified in the airway of children, high rates of codetection of other viral pathogens and detection of the virus in the stool have raised questions about the true role of HBoV as a cause of respiratory infections. A focus on epidemiology, pathogenesis, clinical features, and diagnostic techniques for hMPV and HBoV is presented.

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Section: Human Metapneumovirusmentioning

confidence: 99%

Human Metapneumovirus and Human Bocavirus in Children

Milder

Arnold

2009

Pediatr Res

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“…Since hMPV was first reported (van den Hoogen et al, 2001) in 2001, much progress has been made in its detection Ebihara et al, 2003Ebihara et al, , 2004Hamelin and Boivin, 2005;Leung et al, 2005;Mackay et al, 2003;Maertzdorf et al, 2004), in understanding its genetic diversity Falsey et al, 2003;Ludewick et al, 2005;Mackay et al, 2003) and in documenting its varied clinical presentation (Falsey et al, 2003;Principi et al, 2006). By linking demographic and clinical data to a large, 3-year, viral culture specimen repository, we sought to describe hMPV infections among patients evaluated by a large US Midwestern referral laboratory.…”

Section: Introductionmentioning

confidence: 99%

Multi-year study of human metapneumovirus infection at a large US Midwestern Medical Referral Center

Gray

Capuano

Setterquist

et al. 2006

Journal of Clinical Virology

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Background-Because of its recent identification, few multi-year epidemiologic studies of hMPV infection have been reported.Objective-We sought to retrospectively describe hMPV infections among patients evaluated by a large US Midwestern referral laboratory. Results-34 (2.6%) of 1294 specimens were hMPV positive. Among these, 21 (62%) were culture positive and available for genetic typing. A previously considered rare genotype of hMPV, B1, was the most common single genotype identified, comprising 9 (43%) of the 21 isolates. Multivariate logistic regression modeling identified patients aged 0.4-9 years (OR = 8.9; 95% CI = 2.0-38.5) and those under intensive care (OR = 3.2; 95% CI = 1.1-8.7) as more likely to have hMPV infection than their peers.Conclusion-In this large referral hospital viral assays more often had evidence of hMPV when they were collected from children receiving intensive care.

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“…19 Meanwhile, there have been several reports regarding the seroprevalence of hMPV infection around the world. Almost all people acquire seropositivity for hMPV by the age of 10 years, 2 and hMPV is known to infect individuals repeatedly throughout adult life and into old age. [5][6][7][8][9] Although there are no reports of IgG titer differences between patients with hypertension and normotensive controls after individual infections with pathogens, including hMPV, it is possible that hypertension itself may increase the anti-IgG titer in response to repeated hMPV infections in the elderly.…”

Section: Discussionmentioning

confidence: 99%

“…1 This virus is a member of the genus metapneumovirus of the subfamily Pneumovirinae of the family Paramyxoviridae. hMPV induces infections of the lower respiratory tract, including bronchitis, bronchiolitis and pneumonia, in young children 2 and immunocompromised individuals, 3 along with upper respiratory tract illnesses and influenza-like illness. 4 In January 2005, we reported an outbreak of nosocomial hMPV infection in elderly subjects in a long-term care facility (LTCF) in Japan.…”

Section: Introductionmentioning

confidence: 99%

Association between human metapneumovirus seroprevalence and hypertension in elderly subjects in a long-term care facility

et al. 2011

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Recently, relations between hypertension and infections caused by several pathogens have been reported. However, few studies have examined the relationship between human metapneumovirus (hMPV) and hypertension in elderly inpatients. To assess the association between anti-hMPV-immunoglobulin G (IgG) titer and the prevalence of hypertension, we conducted a case-control study in a Japanese long-term care facility (LTCF). The participants included 84 hypertensive patients aged X65 years, and 84 age-and sex-matched normotensive controls (38 males and 46 females in each group; cases, 79.9 ± 8.4 (s.d.) years; controls, 80.1 ± 8.3 years). Data on underling chronic clinical conditions were collected. Titers were measured using an immunofluorescence assay kit. The significance of risk factor differences was analyzed using univariate and multivariate comparisons of cases and controls. All serum samples were positive for hMPV, and IgG titers ranged from 40-fold to more than 5120-fold. There were no significant sex-or age-related differences in log 2 (anti-hMPV-IgG titer/10) among the subjects. Compared with normotensive subjects, hypertensive patients presented significantly higher log 2 (anti-hMPV-IgG titer/10) values (Po0.001). After adjustment with multiple logistic analysis, the odds ratio for log 2 (anti-hMPV-IgG titer/10) was 1.42 (95% confidence interval 1.16-1.75, P¼0.001) relative to normotensive subjects. In all subjects, stepwise multiple regression analysis revealed that both hypertension and a poor nutritional state independently contributed to increased log 2 (anti-hMPV-IgG titer/10). These observations suggest that an increased anti-hMPV-IgG titer was closely related to hypertension in elderly subjects in a Japanese LTCF.

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Seroprevalence of human metapneumovirus in Japan

Cited by 131 publications

References 10 publications

Human Metapneumovirus and Human Bocavirus in Children

Human Metapneumovirus and Human Bocavirus in Children

Multi-year study of human metapneumovirus infection at a large US Midwestern Medical Referral Center

Association between human metapneumovirus seroprevalence and hypertension in elderly subjects in a long-term care facility

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