Seroprevalence of<i>Bordetella pertussis</i>Infection in Patients With Chronic Obstructive Pulmonary Disease in England: Analysis of the AERIS Cohort

Wilkinson, Tom; Steen, Peter van; Cheuvart, Brigitte; Baudson, Nathalie; Dodet, Monique; Turriani, Elisa; Harrington, Lauriane; Meyer, Nadia; Rondini, Simona; Taddei, Laura; Mukherjee, Pritish

doi:10.1080/15412555.2021.1920904

Cited by 16 publications

(9 citation statements)

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“…Concerning underreporting, data from the present study seem to confirm what has been observed in other countries and/or in different settings and confirm the need for more effective epidemiological surveillance [40,41]. Relevant surveillance gaps have been reported from several LMIC countries as well [42].…”

Section: Discussionsupporting

confidence: 89%

Sero-Epidemiological Study of Bordetella pertussis Infection in the Italian General Population

Grassi

Bagordo²,

Savio³

et al. 2022

Vaccines

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A multicenter study was conducted to estimate the prevalence of pertussis IgG antibodies (anti-PTx) in the Italian population. Serum samples (4154) collected in the years 2019–2020 from subjects aged 6 to 90 years were tested. The anti-PTx IgG levels were determined by ELISA test. The limit of detection was 5 IU/mL (International Units per milliliter); values ≥ 40 IU/mL and ≥100 IU/mL indicate an infection that has occurred in recent years and a recent infection (occurred during the last year), respectively. The mean concentration of anti-PTx IgG antibodies in the tested samples was 13 IU/mL; 1.0% of subjects had a titer ≥ 100 IU/mL, 5.3% a titer between 40 and 100 IU/mL, and 38.9% a titer < 5 IU/mL. The mean antibody concentration was significantly higher in males than in females. The age group 25–39 years had the lowest percentage of negative subjects (36.9%) and the highest prevalence of subjects with antibody titers ≥ 100 IU/mL (1.3%). In the age group ≥ 65 years, the prevalence of subjects with titers between 40 and 100 IU/mL (6.7%) and the percentage of negative subjects (44.8%) was higher than in the other age groups. The results highlight the possible role of adolescents and adults in the transmission of B. pertussis.

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Section: Discussionsupporting

confidence: 89%

Sero-Epidemiological Study of Bordetella pertussis Infection in the Italian General Population

Grassi

Bagordo²,

Savio³

et al. 2022

Vaccines

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show abstract

“…Other complications are less frequent and include seizures and encephalopathy (cerebral hypoxia related to asphyxia), subarachnoid and intraventricular haemorrhages, and tetanic seizures [ 45 ]. Individuals with underlying conditions, such as asthma, chronic obstructive pulmonary disease (COPD), and obesity are at an even higher risk to develop a severe form of the disease [ 46 – 48 ], and recent studies suggest that pertussis incidence in COPD populations may be grossly underestimated [ 49 , 50 ]. Pertussis has been associated with an increase in healthcare resource use in patients with COPD and asthma, increasing the overall economic burden, exacerbation, and hospitalisation rate related to the disease [ 51 – 53 ].…”

Section: Burden Of Pertussis In Adultsmentioning

confidence: 99%

Improving vaccination rates in older adults and at-risk groups: focus on pertussis

Choi¹,

Sousa

Fletcher

et al. 2022

Aging Clin Exp Res

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Despite the implementation of effective paediatric vaccination programmes, pertussis remains a global health problem. Disease epidemiology has changed over time, shifting towards the adolescent and adult populations. In adults, the true burden of pertussis is greatly underestimated and pertussis vaccine coverage rates are suboptimal, including individuals with chronic conditions. Here, we report the outcomes of a virtual international scientific workshop to assess the evidence on the burden of pertussis in older adults and identify potential solutions to improve uptake of pertussis vaccines. In adults, pertussis is underdiagnosed in part due to atypical or milder clinical presentation and the lack of testing and case confirmation. However, contemporary epidemiological data denoted an increase in the burden of pertussis among adolescents and adults. This might be related to a variety of reasons including the waning of immunity over time, the lack of booster vaccination, and the improved diagnostic methods that led to increased recognition of the disease in adults. Pertussis sequelae can be severe in older adults, particularly those with existing chronic medical conditions, and the vulnerability of these groups is further enhanced by low pertussis vaccine coverage. Possible measures to increase vaccine uptake include strengthening and harmonisation of immunisation guidelines, healthcare professionals taking a more active role in recommending pertussis vaccination, involvement of vaccination centres and pharmacies in the vaccination process, and improving knowledge of pertussis burden and vaccine efficacy among the general population.

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“…[8][9][10] Data from patients with chronic obstructive pulmonary disease (COPD) in England also support this under-recognition, as the rate of diagnosed pertussis was approximately 5 per 100,000 in 2013, 11 but a seroprevalence study in the same year indicated that 5.8% of COPD patients had antibody levels indicative of exposure to B. pertussis in the past year. 12 Pertussis is particularly under-recognized or misdiagnosed in adults, 13,14 possibly because health care providers often view pertussis as a childhood disease, 15 instead suspecting acute bronchitis or simply "cough", 16 also because adults can be asymptomatic 17 or present with mild or atypical symptoms. 18 Asthma affects approximately 7% of adults in the United Kingdom (UK) based on data from 2016.…”

Section: Introductionmentioning

confidence: 99%

Burden of Pertussis in Individuals with a Diagnosis of Asthma: A Retrospective Database Study in England

Bhavsar¹,

Aris²,

Harrington³

et al. 2022

JAA

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Purpose:The impact of pertussis in individuals with asthma is not fully understood. We estimated the incidence, health care resource utilization (HCRU), and direct medical costs (DMC) of pertussis in patients with asthma. Patients and Methods: In this retrospective cohort study, the incidence rate of pertussis (identified using diagnostic codes) among individuals aged ≥50 years with an asthma diagnosis was assessed during 2009-2018 using Clinical Practice Research Datalink and Hospital Episode Statistics databases. HCRU and DMC were compared -between patients with diagnoses of asthma and pertussis (asthma+/pertussis+) and propensity score-matched patients with a diagnosis of asthma without pertussis (asthma+/pertussis-) -in the months around the pertussis diagnosis (-6 to +11). Results: Among 687,105 individuals, 346 had a reported pertussis event (incidence rate: 9.6/ 100,000 person-years of follow-up; 95% confidence interval: 8.6-10.7). HCRU and DMC were assessed among 314 asthma+/pertussis+ patients and 1256 matched asthma+/pertussiscontrols. Baseline HCRU was similar in both cohorts, but increases were observed in the asthma+/pertussis+ cohort from -6 to -1 month before to 2-5 months after diagnosis. Rates of accident and emergency visits, general practitioner (GP)/nurse visits, and GP prescriptions were 4.3-, 3.1-, and 1.3-fold, respectively, in the asthma+/pertussis+ vs asthma+/pertussiscohorts during the month before diagnosis; GP/nurse visit rates were 2.0-and 1.2-fold during 0-2 and 2-5 months after diagnosis, respectively (all p<0.001). DMC was 1.9-and 1.6-fold during the month before and 2 months from diagnosis, respectively, in the asthma+/pertussis + vs asthma+/pertussis-cohorts (both p<0.001). During months -1 to +11, DMC in the asthma+/pertussis+ cohort was £370 higher than in the asthma+/pertussis-controls. Conclusion: A pertussis diagnosis among adults aged ≥50 years with asthma resulted in significant increases in HCRU and DMC across several months around diagnosis, suggesting lengthy diagnosis times and highlighting the need for prevention strategies.

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Seroprevalence ofBordetella pertussisInfection in Patients With Chronic Obstructive Pulmonary Disease in England: Analysis of the AERIS Cohort

Cited by 16 publications

References 50 publications

Sero-Epidemiological Study of Bordetella pertussis Infection in the Italian General Population

Sero-Epidemiological Study of Bordetella pertussis Infection in the Italian General Population

Improving vaccination rates in older adults and at-risk groups: focus on pertussis

Burden of Pertussis in Individuals with a Diagnosis of Asthma: A Retrospective Database Study in England

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