Seroprevalence of <i><scp>T</scp>rypanosoma cruzi</i> in kidney transplant donors and recipients in <scp>M</scp>exico <scp>C</scp>ity

Rodríguez-Romo, Roxana; Morales‐Buenrostro, Luis E.; Reyes, Pedro A.; Gracida, C; Medeiros-Domingo, Mara; Mancilla, E; Leo, Claudia de; Alberú, Josefina

doi:10.1111/tid.12122

Cited by 5 publications

(4 citation statements)

References 14 publications

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“…In Southern California, a 0.3% prevalence was reported from 2002 to 2004. In the Los Angeles County blood bank, confirmed seroreactivity for T. cruzi was found to be 0.1% [21][22][23][24] . In most Brazilian states, death from TBI is decreasing while death from stroke is increasing among deceased donors 25 .…”

Section: Discussionmentioning

confidence: 99%

Trypanosoma cruzi seroprevalence among solid organ donors in Ceará State, Brazil

Costa

Filho

Rocha

et al. 2018

Rev. Soc. Bras. Med. Trop.

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Introduction: The transmission of Chagas disease (CD) through blood transfusion, organ transplantation, and oral transmission has gained greater visibility as a result of intensified vector control activities in endemic regions and to control CD in nonendemic regions. In Brazil, Ceará is one of the states that perform the most organ transplants. Therefore, the objective of this study was to assess the prevalence of Trypanosoma cruzi infection in organ donor candidates. Methods: A retrospective analysis was performed on data from potential organ donors at the Center of Transplantation of the State of Ceará from 2010-2015. Results: Data from a total of 2,822 potential donors were obtained, of which 1,038 were effective donors and 1,784 were excluded, likely due to lack of family authorization or medical contraindication. The prevalence of T. cruzi infection among these potential donors was 1.3% (n = 29). The majority of infected donors were males aged 41-60 years, residing in the interior of the state. Interestingly, 72.4% (n = 21) had positive or inconclusive serology for additional infections, such as cytomegalovirus, hepatitis B and C, and toxoplasmosis. Probability analysis revealed that stroke was the most common cause of death among potential donors with CD. Conclusions: There was a high prevalence of CD and other coinfections among potential solid organ donors in Ceará, and statistical tests have shown that these individuals are at increased risk of stroke when compared to potential non-reactive donors. This work highlights the importance of screening DC infection in potential donors.

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Section: Discussionmentioning

confidence: 99%

Trypanosoma cruzi seroprevalence among solid organ donors in Ceará State, Brazil

Costa

Filho

Rocha

et al. 2018

Rev. Soc. Bras. Med. Trop.

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“…Prevalence of Chagas disease in these studies ranged from 0% to 10.7% depending on the country where the study was performed, the study period, and the serological test used for the diagnosis. 7,[18][19][20][21] Although our study is performed in a Data are reported as number (%) of patients or median (range). * These two patients were born in Spain, but they lived for more than 1 year in Venezuela and Mexico, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…[7][8][9]11 Some Brazilian studies have shown higher risk of Chagas disease reactivation in heart transplant recipients receiving mycophenolate mofetil as a part of the immunosuppression protocol. Therefore, it is recommended not to use mycophenolate mofetil (or at least use reduced doses) in 18 Riarte, 1999 7 Boin, 2010 19 Fitzpatrick, 2010 20 Rodríguez-Romo, 2013 21 Salvador, 2018 1975-1986 1989-1996 1997-2007 2006-2008 2009- Chagas disease patients receiving heart transplantation. 28,29 Nevertheless, no information in other organ transplantations is available.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Chagas Disease among Solid Organ–Transplanted Patients in a Nonendemic Country

Salvador

Sánchez-Montalvà

Sulleiro

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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Reactivation of Chagas disease in the chronic phase may occur after solid organ transplantation, which may result in high parasitemia and severe clinical manifestations such as myocarditis and meningoencephalitis. The aim of the present study is to describe the prevalence of Chagas disease among solid organ-transplanted patients in a tertiary hospital from a nonendemic country. A cross-sectional study was performed at Vall d'Hebron University Hospital (Barcelona, Spain) from April to September 2016. Chagas disease screening was performed through serological tests in adult patients coming from endemic areas that had received solid organ transplantation and were being controlled in our hospital during the study period. Overall, 42 patients were included, 20 (47.6%) were male and median age was 50.5 (23-73) years. Transplanted organs were as follows: 18 kidneys, 17 lungs, and 7 livers. Three patients had Chagas disease, corresponding to a prevalence among this group of solid organ-transplanted patients of 7.1%. All three patients were born in Bolivia, had been diagnosed with Chagas disease and received specific treatment before the organ transplantation. We highly recommend providing screening tests for Chagas disease in patients with or candidates for solid organ transplantation coming from endemic areas, early treatment with benznidazole, and close follow-up to prevent clinical reactivations.

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“…The epidemiology of Chagas Disease in Mexico is still poorly understood, but a recent systematic review of surveys from 2006 to 2017 estimated seroprevalence of T. cruzi infection of 3.38%, corresponding to 4.06 million cases (Arnal et al ., 2019). Although T. cruzi transmission in humans may occur by the congenital transmission (Buekens et al ., 2018), transfusions (Escamilla‐Guerrero et al ., 2012) and organ transplants (Rodríguez‐Romo et al ., 2013), the most common route is by contact with contaminated faeces or urine of Triatomine bugs (Ramsey et al ., 2000; Pizano & Gascón, 2015). Currently, in Mexico seven genera and 31 species have been recorded, of which 19 species are the most abundant as well as the epidemiologically relevant vectors of T. cruzi (Ramsey et al ., 2015) and 11 species are part of the most important complex in that country, the Phyllosoma complex.…”

Section: Introductionmentioning

confidence: 99%

Pattern of climate connectivity and equivalent niche of Triatominae species of the Phyllosoma complex

Moo‐Llanes

Oca-Aguilar

Rodríguez‐Rojas

2020

Medical Vet Entomology

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The Phyllosoma complex is a Triatominae (Hemiptera: Reduviidae) group of medical importance involved in Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae) transmission. Most of the members of this group are endemic and sympatric species with distribution in Mexico and the southern U.S.A. We employed MaxEnt to construct ecological niche models of nine species of Triatominae to test three hypothesis: (a) whether species with a broad climatic niche breadth occupy a broader geographical range than species with a narrow climatic breadth, (b) whether species with broad distribution present high degree of climatic fragmentation/isolation, which was tested through landscape metrics; and (c) whether the species share the same climatic niche space (niche conservatism) considered through an equivalence test implemented in ENMtools. Overall, our results suggest that the geographical distribution of this complex is influenced mainly by temperature seasonality where all suitable areas are places of current and potential transmission of T. cruzi. Niche breadth in the Phyllosoma complex is associated with the geographical distribution range, and the geographical range affects the climatic connectivity. We found no strong evidence of niche climatic divergence in members of this complex. We discuss the epidemiological implications of these results.

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Seroprevalence of Trypanosoma cruzi in kidney transplant donors and recipients in Mexico City

Cited by 5 publications

References 14 publications

Trypanosoma cruzi seroprevalence among solid organ donors in Ceará State, Brazil

Trypanosoma cruzi seroprevalence among solid organ donors in Ceará State, Brazil

Prevalence of Chagas Disease among Solid Organ–Transplanted Patients in a Nonendemic Country

Pattern of climate connectivity and equivalent niche of Triatominae species of the Phyllosoma complex

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