Seroprevalence of <i>Toxoplasma gondii</i> infection in sheep in Inner Mongolia Province, China

Yan, Xing‐Gang; Han, Wenying; Wang, Yan; Gao, Zhihui

doi:10.1051/parasite/2020008

Cited by 13 publications

(11 citation statements)

References 20 publications

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“…The results showed that ducks 1<years≤2 of age (OR: 4.1; 95% CI: 1.0–17.2) had four times higher risk of being positive compared with ducks ≤1 year-old, indicating that age may be a risk factor for T. gondii infection, in agreement with previous studies ( 40 – 43 ). Age is widely considered as a risk factor for high infection rates of T. gondii ( 44 , 45 ). This might be attributed to increased frequency of exposure to the infectious T. gondii oocysts or the cumulative effect of the time period during which an animal can be exposed to the parasite ( 43 , 46 ).…”

Section: Discussionmentioning

confidence: 99%

Molecular Detection of Toxoplasma gondii and Neospora caninum in Domestic Ducks in Hunan Province, China

Zheng

Yang

et al. 2021

Front. Vet. Sci.

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Toxoplasma gondii and Neospora caninum are protozoan parasites that infect warm-blooded animals, and cause major economic losses in livestock industries worldwide. However, little is known about the genotypes of T. gondii and N. caninum in domestic ducks in China. Herein, brain samples from 588 domestic ducks from Hunan province in China were examined for the presence of T. gondii and N. caninum. Polymerase chain reaction (PCR) was used to detect T. gondii B1 gene and N. caninum NC-5 gene. Forty-five DNA samples (7.7%; 95% CI: 5.5–9.9) were positive for B1 gene, and two (0.3%; 95% CI: 0–0.7) were positive for NC-5 gene. The risk factors significantly associated with T. gondii infection were age and sex. The 45 samples positive for T. gondii were genotyped using multi-locus PCR-RFLP analysis and only one sample was fully genotyped as ToxoDB#9 (Chinese I). These results provide new information about the epidemiology of T. gondii and N. caninum in ducks in Hunan province in China. The data also highlight the importance of a “One Health” approach to dealing with toxoplasmosis.

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Section: Discussionmentioning

confidence: 99%

Molecular Detection of Toxoplasma gondii and Neospora caninum in Domestic Ducks in Hunan Province, China

Zheng

Yang

et al. 2021

Front. Vet. Sci.

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“…Adopted stray cats in our study live in Khao Suan Kwang district next to Khon Kaen Zoo, which is a rural area far away from Mueang district, about 50 km. In the zoo, many animals can be intermediate hosts of T. gondii, such as sheep [30], goats [31], rusa deer [32], and other Felidae [33], among others. Furthermore, a high incidence of T. gondii infection in captive felids, that is, 15.4%-18.84%, was reported in Thailand [18,34].…”

Section: Discussionmentioning

confidence: 99%

Serological survey of Toxoplasma gondii infection in cats in Khon Kaen, Northeast Thailand

et al. 2022

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Background and Aim: Toxoplasmosis is a zoonosis caused by Toxoplasma gondii. Cats are known to be the definitive hosts that can excrete these environmentally resistant oocysts. Other mammals, avians, and even humans can serve as the intermediate host. T. gondii infection is often asymptomatic in healthy individuals; however, it could result in serious health problems in immunocompromised and pregnant individuals. This study investigated the occurrence of T. gondii infection in cats in Khao Suan Kwang and Mueang Khon Kaen. Materials and Methods: In total, 100 serum samples from cats, that is, 62 owned cats (31 males and 31 females) and 38 adopted stray cats (21 males and 17 females), were examined for antibodies against T. gondii through rapid immunochromatographic tests (ICT). Owners were asked to sign a consent form and answer the questionnaires before sample collection. Demographic information about the cats and their owners was also recorded. Results: The overall seroprevalence of cats positive for T. gondii antibodies was found to be 5%. Notably, the Toxoplasma antibody prevalence was significantly higher in the adopted stray cats (10.53% [4/38]) that roamed the zoo than in the owned cats (1.61% [1/62]) (p > 0.05). No significant difference was observed between male (8.33%) and female (1.92%) cats. The cat owners' questionnaire revealed that more than half had never heard of toxoplasmosis before (67.7%), whereas 30.6% knew nothing about the disease transmission routes. Conclusion: This study presented a low seroprevalence of antibodies to T. gondii in owned cats from the Mueang Khon Kaen District, whereas high seroprevalence was detected in the adopted stray cats from Khao Suan Kwang. Adopted stray cats can have a higher potential for T. gondii infection; thus, they could be a source of toxoplasmosis transmission to humans. Therefore, it is essential to control the number of stray cats, and a screening test for antitoxoplasmosis could be recommended before adoption. Although the total seroprevalence was noted to be low, the zoonotic disease was present. Therefore, raising the community's awareness and knowledge might reduce the disease transmission from animals to humans.

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“…The Inner Mongolia Autonomous Region holds a significant position in the livestock sector of China. The livestock economy is regarded as one of the crucial industries in the region and serves as the primary economic backbone for the local herders [ 2 ]. Nonetheless, several studies have shown that grazing sheep may not receive sufficient mineral intake, such as copper (Cu), from natural forages to support their optimal growth and development [ 3 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

Transcriptomics and metabolomics analysis reveal the dietary copper deficiency and supplementation effects of liver gene expression and metabolite change in grazing sheep

Jin,

Meng,

et al. 2024

BMC Genomics

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Background The appropriate mineral nutrients are essential for sheep growth and reproduction. However, traditional grazing sheep often experience mineral nutrient deficiencies, especially copper (Cu), due to inadequate mineral nutrients from natural pastures. Results The results indicated that dietary Cu deficiency and supplementation significantly reduced and elevated liver concentration of Cu, respectively (p < 0.05). FOXO3, PLIN1, ACTN2, and GHRHR were identified as critical genes using the weighted gene co-expression network analysis (WGCNA), quantitative real-time polymerase chain reaction (qRT-PCR), and receiver operating characteristic curve (ROC) validation as potential biomarkers for evaluating Cu status in grazing sheep. Combining these critical genes with gene functional enrichment analysis, it was observed that dietary Cu deficiency may impair liver regeneration and compromise ribosomal function. Conversely, dietary Cu supplementation may enhance ribosomal function, promote lipid accumulation, and stimulate growth and metabolism in grazing sheep. Metabolomics analysis indicated that dietary Cu deficiency significantly decreased the abundance of metabolites such as cholic acid (p < 0.05). On the other hand, dietary Cu supplementation significantly increased the abundance of metabolites such as palmitic acid (p < 0.05). Integrative analysis of the transcriptome and metabolome revealed that dietary Cu deficiency may reduce liver lipid metabolism while Cu supplementation may elevate it in grazing sheep. Conclusions The Cu content in diets may have an impact on hepatic lipid metabolism in grazing sheep. These findings provide new insights into the consequences of dietary Cu deficiency and supplementation on sheep liver and can provide valuable guidance for herders to rationalize the use of mineral supplements.

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Seroprevalence of Toxoplasma gondii infection in sheep in Inner Mongolia Province, China

Cited by 13 publications

References 20 publications

Molecular Detection of Toxoplasma gondii and Neospora caninum in Domestic Ducks in Hunan Province, China

Molecular Detection of Toxoplasma gondii and Neospora caninum in Domestic Ducks in Hunan Province, China

Serological survey of Toxoplasma gondii infection in cats in Khon Kaen, Northeast Thailand

Transcriptomics and metabolomics analysis reveal the dietary copper deficiency and supplementation effects of liver gene expression and metabolite change in grazing sheep

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