Seroprevalence of Igm Antibodies Against the Agents of Torch Infections Among the Patients Visiting National Public Health Laboratory, Teku Kathmandu

Lamichhane, Sujata; Malla, Sarala; Basnyat, S.; Khanal, S.; Dumre, S.; Maharjan, Laxman; Shrestha, P.

doi:10.3126/jnhrc.v5i2.2467

Cited by 5 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lower seroprevalance were found in studies done in other countries (Ribeiro et al 2008, Alvarado-Esquivel et al 2009. Among the women with BOH, prevalence of IgM antibodies against T. gondii was found to be 17.84% which was in concordance with the finding of a comparable study (15.43%) conducted earlier (Lamichhane et al 2007). In a recent study in India, 21.9% of women with BOH were positive to T. gondii IgM antibodies (Sarkar et al 2012).…”

Section: Resultssupporting

confidence: 80%

“…In pregnant women, rubella might cause multiple organ defects in fetuses, which is called congenital rubella syndrome (CRS) (Webester 1998). In our study, Rubella IgM seropositivity in women with BOH was 11.06% which was higher than found in an earlier study in Nepal (4%) (Lamichhane et al 2007).…”

Section: Resultscontrasting

confidence: 59%

“…In this study, CMV IgM seroprevalance was found to be 18.57% in BOH patients. Similar study done in Nepal showed 9.33% (Lamichhane et al 2007). In a study done in India recently, 34.7% BOH patients were positive to CMV IgM (Sen et al 2012) while other studies showed lower seroprevalence (Turbadkar et al 2003, Sadik et al 2012.…”

Section: Resultsmentioning

confidence: 72%

See 2 more Smart Citations

Prevalence of Serum Antibodies to TORCH Infections among the Women of Child Bearing Age Visiting National Public Health Laboratory, Teku

Lamichhane

Pudasaini

Upadhyay

et al. 2015

Nepal Journal of Science and Technology

View full text Add to dashboard Cite

The primary infection of Toxoplasma gondii, Rubella virus, Cytomegalovirus (CMV) and Herpes simplex virus (HSV) abbreviated as TORCH, remain a major problem in the women of child bearing age in Nepal. The main aim of this study was to determine the seroprevalence of TORCH infections among the women of child bearing age visiting the National Public Health Laboratory (NPHL), Kathmandu. Serum samples collected from 302 patients were tested for TORCH infections by IgM Enzyme Linked Immunosorbent Assay (ELISA). The seropositivity rate was found to be 18.82% (54/287) for T. gondii, 10.07% (28/278) for Rubella, 16.49% (46/279) for CMV and 23.34% (67/287) for HSV. The seropositivity rates in pregnant women were 17.92% (19/106) for T. gondii, 11.54% (12/104) for Rubella, 19.23% (20/104) for CMV and 25% (26/104) for HSV, the statistical association of TORCH infections with pregnancy was insignificant (P>0.05). Similarly, the seropositivity rates in women with bad obstetric history (BOH) were 17.84% (43/241) for T. gondii, 11.06% (26/235) for Rubella, 18.57% (44/237) for CMV and 26.14% (63/241) for HSV. The statistical association of CMV and HSV with previous obstetric performance were significant (P>0.05) while that of T. gondii and Rubella were insignificant (P<0.05). The seropositivity rate was found to be highest for HSV infection (23.34%) followed by T. gondii (18.82%), Cytomegalovirus (16.49%) and Rubella (10.07%).DOI: http://dx.doi.org/njst.v15i2.12120Nepal Journal of Science and Technology Vol. 15, No.2 (2014) 85-90

show abstract

Section: Resultssupporting

confidence: 80%

Section: Resultscontrasting

confidence: 59%

See 1 more Smart Citation

Prevalence of Serum Antibodies to TORCH Infections among the Women of Child Bearing Age Visiting National Public Health Laboratory, Teku

Lamichhane

Pudasaini

Upadhyay

et al. 2015

Nepal Journal of Science and Technology

View full text Add to dashboard Cite

show abstract

“…About 10 to 20 percent of infected infants may suffer sensorineural hearing loss, ocular damage or impairment of cognitive and motor function. 3 The common modes of infection of this DNA virus are through saliva (kissing), urine, stool, breast milk and unscreened blood tramsmission. For most healthy people who acquire CMV infection after birth or through blood transfusion, there are few symptoms and no long term sequelae.…”

Section: Introductionmentioning

confidence: 99%

“…Only one IgM seropositive case in our study is not in accordance with another study done in Nepal Public Health Laboratory (NPHL) where around 15% IgM seropositive cases were detected however that study was performed on the subjects of suspected TORCH infections and the study site is a referral center for diagnosis of infectious diseases. 3 Decreasing trends of seropositivity of cytomegalovirus was observed in Japan where approximately 35% pregnant women are still infected with CMV. 9 A national health and nutrition examination surveys from United State of America shows that many women of reproductive age are still at risk of primary CMV infection during pregnancy.…”

mentioning

confidence: 99%

Immune status in infection by cytomegalovirus in women with bad obstetric history

Acharya

Shrestha

Bogati

et al. 2013

Int J Infection & Microbiol

View full text Add to dashboard Cite

INTRODUCTION:Viral infections during pregnancy carry a risk for intrauterine transmission which may result in fetal damage. Bad obstetric history implies for previous unfavorable foetal outcome in terms of two or more consecutive spontaneous abortions, history of intrauterine foetal death, intrauterine growth retardation, still birth, early neonatal death and congenital anomalies. Cytomegalovirus, a ubiquitous virus belonging to the herpes family, is known to cause abnormal fetal outcome. We aim to determine the possible involvement of CMV infection among pregnant women with bad obstetric history MATERIALS AND METHODS: A cross sectional study was carried out among 136 women with bad obstetric outcome attending Dhulikhel HospitalKathmandu University Hospital. The cytomegalovirus specific IgG and IgM antibodies were determined by ELISA test. Data were analyzed using SPSS, version 17.0 and interpreted according to frequency distribution and percentage. The data was considered significant if the p-value was <0.05. RESULTS:The results revealed that 87 (63.9%) out of 136 patients were positive for CMV IgG antibodies and only one (0.007%) patient was positive for CMV IgM. The majority of the patients were of the age between 20 and 29 years (99/136) and it was observed that most of the positive CMV IgG were participants of the same age group (63/ 99). There was no significant association of CMV seropositivity with the age of participants (p value 0.9).CONCLUSION: CMV infection could be the risk factor for BOH and may play a vital role in determining the foetal outcome. Thus we recommend routine serological testing to all pregnant women with or without BOH attending the antenatal clinics for both CMV specific IgG and IgM.

show abstract

Serological Screening of TORCH Agents as an Etiology of Spontaneous Abortion in Dhulikhel Hospital, Nepal

Acharya¹

2014

AJBLS

View full text Add to dashboard Cite

The role of TORCH infections as a cause of spontaneous abortions is still debatable with conflicting results where geographical variation may play a significant role. This study was undertaken to discover the association of TORCH infections in women with spontaneous abortions by serological testing. The descriptive case control study was conducted from January to December, 2012. A serological evaluation was carried out to determine the presence of Toxoplasma gondii, Rubella, Cytomegalovirus (CMV) and Herpes Simplex Virus (HSV) specific immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies, using commercial diagnostic kits by enzyme-linked immunosorbent assay (ELISA) technique. Mean age of the study and control subjects were 24.8+/-6.4 and 23.8+/-3.8 years respectively where 72.8% of the study subjects were of the age between 20 to 35 years and 23% of the women with spontaneous abortion were below 20 years. Most of the cases were of incomplete abortions (43%) followed by complete abortions (26%). Only 1.3% of both IgG and IgM seropositivity against TORCH agents were noted among the study subjects whereas highest IgG seropositivity was detected with Rubella (86.8%) followed by HSV-I (72.8%). An infection susceptibility rate of 77.9% to Toxoplasma gondii, 11.7% to Rubella, 51.9% to CMV, 36.4% to HSV-I and 84.4% to HSV-II was noted. No significant difference in relation to age and type of abortion was found in seropositivity between the study and the control subjects. This study, probably the first of its kind from Nepal, suggests that current infection with TORCH agents might not be the possible etiology of spontaneous abortion. Serological TORCH screening may not be conclusive.

show abstract

Seroprevalence of Igm Antibodies Against the Agents of Torch Infections Among the Patients Visiting National Public Health Laboratory, Teku Kathmandu

Abstract: Not uploaded.Key words: TORCH infection; Serum; IgM; ELISADOI: 10.3126/jnhrc.v5i2.2467Journal of Nepal Health Research Council (JNHRC) Vol. 5, No.2, October 2007 21-25

Cited by 5 publications

References 0 publications

Prevalence of Serum Antibodies to TORCH Infections among the Women of Child Bearing Age Visiting National Public Health Laboratory, Teku

Prevalence of Serum Antibodies to TORCH Infections among the Women of Child Bearing Age Visiting National Public Health Laboratory, Teku

Immune status in infection by cytomegalovirus in women with bad obstetric history

Serological Screening of TORCH Agents as an Etiology of Spontaneous Abortion in Dhulikhel Hospital, Nepal

Contact Info

Product

Resources

About