Seroprevalence of known and putative hepatitis markers inUnited States blood donors with ALT levels at least 120 IU per L

Notari, Edward P.; Orton, Sharyn; Cable, Ritchard G.; Grindon, Alfred J.; Lenes, Bruce A.; Williams, Alan E.; McMillan, Kimberly M.; Trouern‐Trend, Jonathan; Wolf‐Nugent, Jennifer S.; Xu, Yiling; Dodd, Roger Y.

doi:10.1046/j.1537-2995.2001.41060751.x

Cited by 22 publications

(16 citation statements)

References 14 publications

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“…This decline may be attributed to two reasons: improvements in socioeconomic status and the consistency of voluntary blood donors (the majority of whom are males between the age of 18 and 35 years old). However, the seroprevalence rates found in our study are still much higher than those in published data about blood donors in the United States (Notari et al, 2001). The differences may also be due to sample sizes, study populations, testing methods, and geography.…”

Section: Discussioncontrasting

confidence: 88%

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Prevalence of hepatitis A viral RNA and antibodies among Chinese blood donors

Sun

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Like other developing countries, China was reported to have a relatively high seroprevalence of anti-hepatitis A antibodies (anti-HAV). However, no studies have evaluated the prevalence of anti-HAV and HAV RNA among voluntary blood donors with or without elevated serum alanine transaminase (ALT) levels. Anti-HAV antibodies were detected using an enzyme-linked immunosorbent assay, and reverse transcription quantitative polymerase chain reaction was carried out for detection of HAV RNA. In the current study, we analyzed a total of 450 serum samples with elevated ALT levels (≥40 U/L) and 278 serum samples with non-elevated ALT levels. Seroprevalence rates of anti-HAV were 51.6% in donors with elevated ALT and 41.4% in donors with non-elevated ALT; however, none of the samples was positive for HAV RNA. The results of our study showed lower seroprevalence rates of anti-HAV in blood donors (irrespective of ALT levels) than those in published data on Chinese populations. Although donors with elevated ALT had statistically higher prevalence rates of anti-HAV than did those with non-elevated ALT, none of the serum samples had detectable levels of the active virus. In conclusion, our results demonstrate that the transmission of hepatitis A by blood transfusion will occur rarely.

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Section: Discussioncontrasting

confidence: 88%

“…As seen in Figure 3, women had lower prevalence of anti-HAV than did men. +All comparison values were based on blood donor population samples (Notari EP et al, 2001). …”

Section: Antibodies To Hav Testingmentioning

confidence: 99%

Prevalence of hepatitis A viral RNA and antibodies among Chinese blood donors

Sun

et al. 2015

Genet. Mol. Res.

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“…[1][2][3][4]8 Since the majority of HEV infections are subclinical, 10 17 Scotland 4.7%). 18 The rate of anti-HEV IgG seropositivity in the present study (21.1%) was considerably higher than the rates described above, [11][12][13][14][15][16][17][18] irrespective of ALT concentrations.…”

Section: Discussionmentioning

confidence: 99%

“…Many countries either do not have compulsory ALT testing for blood donors or use a high ALT cut-off value. 7,8 The aim of the current study was to investigate the prevalence of HEV antibodies and RNA in blood donors with elevated or normal ALT concentrations, and to determine whether there is a relationship between ALT concentration and HEV infection.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of hepatitis E virus in Chinese blood donors

Sun

Lin

et al. 2015

J Int Med Res

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Objective: To investigate the prevalence of hepatitis E virus (HEV) antibodies and RNA in voluntary blood donors, in China. Methods: Serum samples from blood donors were collected sequentially at six blood donation centres in five geographical regions of China. Donors were stratified between two groups according to their serum alanine aminotransferase (ALT) concentration ( 40 U/l and >40 U/l. Enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction were used to quantify anti-HEV antibodies and RNA, respectively.

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“…These data suggest that some blood donors' ALT value was 120 U/L or higher, and HBV or HCV infection of serological marker detection is nega-tive, but these donors are still suspicious of HBV or HCV infected. Continued ALT testing may contribute little [7]. Reported in Brazil there are 71 blood donors with single ALT positive and anti-HBV/HCV negative, these donors were followed-up for two years, and none of these donors were detected HBV or HCV positive.…”

Section: Discussionmentioning

confidence: 99%