Seroprevalence of Measles- and Mumps-Specific Immunoglobulin G among Japanese Healthcare Students Increased during 2007&amp;ndash;2012

Kimura, Takao; Tsunekawa, Katsuhiko; Ogiwara, Takayuki; Tokue, Yutaka; Nara, Makoto; Inoue, Toshiya; Obuchi, Toshiko; Suto, Chiaki; Ohshima, Kihachi; Murakami, Masami

doi:10.7883/yoken.66.411

Cited by 9 publications

(5 citation statements)

References 21 publications

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“…2008 to 2012 (Kimura et al 2013;IDSC, NIID 2015). In 2013, a nationwide rubella epidemic occurred in Japan, and an increase in CRS was reported (CDC 2013).…”

Section: Discussionmentioning

confidence: 99%

“…In an effort to eliminate measles and rubella, the Japanese government implemented a two-dose measlesrubella vaccination schedule during childhood in 2006 (IDSC, Infectious Disease Surveillance Center, NIID, National Institute of Infectious Diseases 2007) and a 5-year measles-rubella catch-up vaccination campaign conducted from 2008 to 2012 for cohorts aged 13 and 18 years (Kimura et al 2013;IDSC, NIID 2015). In Japan, the person who was born after 2006 receives two-dose measlesrubella vaccination aged 1 year and 5 years, on the other hand, the person who was born between 1995-2005 received two-dose measles-rubella vaccination aged 1 year and 13 years.…”

Section: Introductionmentioning

confidence: 99%

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Vaccination Status and Antibody Titers against Rubella and Measles among Japanese Female College Students Majoring in Childcare between 2015 and 2018

Shoho

Kimura

Yanagawa

et al. 2018

Tohoku J. Exp. Med.

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In 2014, for the protection of medical workers against measles and rubella infection, the Japanese Society for Infection Prevention and Control (JSIPC) recommended either maintaining antibody titers of seroprotective range or two-dose vaccination. JSIPC defined antibody titers into 3 ranges: seroprotective as expected prevention of infection, seronegative as under detection levels, and seropositive as antibody titers ranged between seronegative and seroprotective. This study aimed to explore the association between the number of vaccine doses received and the antibody titers against measles and rubella among Japanese college students majoring in childcare. A total of 841 female students with no history of measles or rubella were serologically screened at the time of college admission between 2015 and 2018. All 841 students had been vaccinated against measles; 738 (87.8%) received two doses of the measles vaccine and 103 (12.2%) received one dose. Likewise, 839 students, except for two, had been vaccinated against rubella; 719 (85.7%) received two doses of the rubella vaccine and 120 (14.3%) received one dose. We thus found that 107 students (12.7%) were seropositive for measles-specific IgG and 731 (86.9%) attained seroprotective titers. By contrast, in case of rubella-specific IgG, only 462 students (55.1%) attained seroprotective titers, and 371 students (44.1%) were seropositive. The two students without receiving rubella vaccination were classified as seronegative. In conclusion, despite that > 85% of students surveyed had received two doses of measles and rubella vaccines, a substantial number of students remain susceptible to measles and especially rubella at the time of college admission.

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“…2008 to 2012 (Kimura et al 2013;IDSC, NIID 2015). In 2013, a nationwide rubella epidemic occurred in Japan, and an increase in CRS was reported (CDC 2013).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vaccination Status and Antibody Titers against Rubella and Measles among Japanese Female College Students Majoring in Childcare between 2015 and 2018

Shoho

Kimura

Yanagawa

et al. 2018

Tohoku J. Exp. Med.

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“…There were five measles [6,12,13,19,20] and 10 rubella studies [6,12,14,19,25,43,44,63,74,87] in category 2. Each study reported testing specimens obtained from individuals having a range of ages, from infants to adulthood, and compared the seroprevalence in each age group.…”

mentioning

confidence: 99%

A 16-year review of seroprevalence studies on measles and rubella

Dimech¹,

Mulders

2016

Vaccine

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“…Additionally, seroprevalence rates among adolescents and young adults were similar to those reported previously in these age groups in the Japanese population. 10,16 Finally, because the evaluation rates of seroprevalence change between two study periods were conducted using serial 5-year birth cohorts, except infants aged <1 year old, we were only able to specify the 5-year age range in children most affected by the mumps epidemic.…”

Section: Discussionmentioning

confidence: 99%

A seroepidemiological study across age groups before and after the 2010–2011 mumps epidemic in Japan

Morino

Satoh²,

Arai

et al. 2022

Journal of Medical Virology

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In Japan, large-scale mumps epidemics recur every 4-6 years because of low vaccination coverage. This study aimed to describe the seroprevalence of mumps in the Japanese population and identify the age groups most affected. The prevalence of anti-mumps antibodies was evaluated based on 1000 serum samples obtained from the Japanese National Serum Reference Bank. These samples consisted of 50 sera for each of 10 different age groups, collected during 2007-2008 (pre-epidemic period) and 2012-2013 (post-epidemic period). Seropositivity was lowest in the 6-11 months subgroup (3% and 0% in pre-and post-epidemic periods, respectively) and highest in the 10-14 years group (66% and 72% in pre-and post-epidemic periods, respectively). A comparison of anti-mumps antibody prevalence throughout the two periods considered revealed a large rise in seropositivity among the 2004-2008 birth cohort, using that of the 1-4 years group as representative in the pre-epidemic period (from 22% in pre-to 58% in post-epidemic periods; p = 0.0002).These results indicate that most people likely gain antibodies to the mumps virus during their childhood, especially during the first epidemic that they experience after their second year of life. Therefore, children should be vaccinated against mumps soon after their first birthday for effective prevention.

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Seroprevalence of Measles- and Mumps-Specific Immunoglobulin G among Japanese Healthcare Students Increased during 2007–2012

Cited by 9 publications

References 21 publications

Vaccination Status and Antibody Titers against Rubella and Measles among Japanese Female College Students Majoring in Childcare between 2015 and 2018

Vaccination Status and Antibody Titers against Rubella and Measles among Japanese Female College Students Majoring in Childcare between 2015 and 2018

A 16-year review of seroprevalence studies on measles and rubella

A seroepidemiological study across age groups before and after the 2010–2011 mumps epidemic in Japan

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