Seroprevalence of Mosquito-Born and Tick-Born Microorganisms in Human Population of South Backa District

Cvjetković, Ivana Hrnjaković; Petrić, Dušan; Cvjetković, Dejan; Kovačević, Gordana; Radovanov, Jelena; Galović, Aleksandra Jovanović; Pat, Aleksandra; Nikolić, Nataša; Mikić, Sandra Stefan; Milosevic, Vesna

doi:10.46784/e-avm.v9i1.94

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…Similarly, Hristea et al (2001) reported an overall 4.3% seroprevalence of anti- Borrelia IgG antibodies in a healthy population of voluntary blood donors from Romania, which is bordering Serbia on the east [ 38 ]. In Serbia, the presence of anti- Borrelia IgG has been previously determined in a healthy population from South Bačka District (3.22%) in Northern Serbia and in Belgrade city (2.9–8.57%) [ 17 , 33 , 39 ]. The variation in Borrelia spp.…”

Section: Discussionmentioning

confidence: 99%

Shared Odds of Borrelia and Rabies Virus Exposure in Serbia

Banović

Díaz-Sánchez

Mijatović³

et al. 2021

Pathogens

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Lyme borreliosis (LB) is the most common tick-borne disease in Serbia and other European countries. Rabies is a fatal zoonosis distributed worldwide and is caused by the rabies virus. Professionals at risk of rabies—including veterinarians, hunters, communal service workers, and forestry workers—overlap with some professions at a higher risk of exposure to tick bites and tick-borne pathogen infections. We hypothesized that individuals identified by the public health system as at risk of rabies virus infection, and consequently vaccinated against rabies virus, also share a higher likelihood of Borrelia exposure. To test our hypothesis, a case-control study was carried out during 2019 in Serbia to determine the seroprevalence of anti-Borrelia antibodies in two case groups (individuals at risk and vaccinated against rabies virus) and a control group (individuals without risk of rabies). Individuals vaccinated against rabies following either “pre-exposure protocol” (PrEP, n = 58) or “post-exposure protocol” (PEP, n = 42) were considered as rabies risk groups and healthy blood donors (n = 30) as the control group. The results showed higher Borrelia seroprevalence in PrEP (17.2%; 10/58) and PEP (19.0%; 8/42) groups compared with the control group (6.67%; 2/30). Furthermore, odds ratio (OR) analysis showed that risk of rabies (in either the PrEP (OR = 2.91) or PEP (OR = 3.29) groups) is associated with increased odds of being seropositive to Borrelia. However, the difference in Borrelia seroprevalence between groups was not statistically significant (Chi-square (χ²) test p > 0.05). The shared odds of LB and rabies exposure found in this study suggest that, in countries where both diseases occur, the common citizen can be at risk of both diseases when in a risky habitat. These findings are important to guide physicians in targeting high-risk groups, and diagnose LB, and to guide decision-makers in targeting control and prevention measures for both infections in risk areas.

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Section: Discussionmentioning

confidence: 99%

Shared Odds of Borrelia and Rabies Virus Exposure in Serbia

Banović

Díaz-Sánchez

Mijatović³

et al. 2021

Pathogens

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“…Seroprevalence studies indicate a non-negligible exposure of humans to USUV infection risk ( Table 2 ). These studies have been carried out in Austria, Germany, Italy, France, Hungary, the Netherlands, Romania, and Serbia, reporting an USUV antibody prevalence between 0.02% and 3% among healthy blood donors [ 32 , 62 , 69 , 71 , 72 , 75 , 77 , 78 , 79 , 80 , 81 , 82 ]. Higher prevalence (6/7%) was found in more exposed populations, such as forestry workers [ 60 , 78 , 83 ].…”

Section: Human Infectionsmentioning

confidence: 99%

“…These studies have been carried out in Austria, Germany, Italy, France, Hungary, the Netherlands, Romania, and Serbia, reporting an USUV antibody prevalence between 0.02% and 3% among healthy blood donors [ 32 , 62 , 69 , 71 , 72 , 75 , 77 , 78 , 79 , 80 , 81 , 82 ]. Higher prevalence (6/7%) was found in more exposed populations, such as forestry workers [ 60 , 78 , 83 ]. Several of these studies show that USUV circulates more actively in humans than WNV in Europe, and prevalence studies of USUV infection in mosquito vectors in Europe also highlight a higher level of exposure to USUV than to WNV [ 18 , 84 , 85 ].…”

Section: Human Infectionsmentioning

confidence: 99%

Human Usutu Virus Infections in Europe: A New Risk on Horizon?

Cadar

Simonin

2022

Viruses

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The Usutu virus (USUV), a neurotropic mosquito-borne flavivirus discovered in 1959 in South Africa, has spread over the last twenty years across the European continent. This virus follows an enzootic cycle involving mosquitoes and birds. This caused epizootics with significant bird mortality in Europe in 2016 and 2018. It can also occasionally infect humans and other mammals, including horses and bats, which act as incidental or dead-end hosts. The zoonotic risk associated with this succession of avian epizootics in Europe deserves attention, even if, to date, human cases remain exceptional. Human infection is most often asymptomatic or responsible for mild clinical symptoms. However, human Usutu infections have also been associated with neurological disorders, such as encephalitis and meningoencephalitis. One of the major complexities of the study of USUV pathogenesis is the presence of a great diversity of lineages which could co-circulate spatiotemporally. In this review we discuss several aspects of the circulation of Usutu virus in humans in Europe, the neurological disorders associated, involved viral lineages, and the issues and questions raised by their circulation.

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Le virus Usutu : la menace fantôme

et al. 2018

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Usutu virus, an arbovirus discovered in Africa in 1959, has spread over a large part of Europe over the last twenty years causing significant bird mortality as reported in France since 2015. The zoonotic risk, associated with this succession of avian epizootics in Europe, deserves to be taken into account even if human cases remain rare to date. Human infections are most often asymptomatic or present a benign clinical expression. However, neurological complications such as encephalitis or meningoencephalitis have been described. In addition, the recent description of an atypical case of facial paralysis in France suggests that the clinical spectrum of infections caused by Usutu virus is not fully characterized. Finally, the recent history of other arboviral outbreaks invites the scientific community to be extremely vigilant.

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Seroprevalence of Mosquito-Born and Tick-Born Microorganisms in Human Population of South Backa District

Cited by 5 publications

References 6 publications

Shared Odds of Borrelia and Rabies Virus Exposure in Serbia

Shared Odds of Borrelia and Rabies Virus Exposure in Serbia

Human Usutu Virus Infections in Europe: A New Risk on Horizon?

Le virus Usutu : la menace fantôme

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