Seroprevalence of mumps in an epidemic period in Medellín, Colombia

Santacruz-Sanmartín, Eduardo; Hincapié-Palacio, Doracelly; Ospina, Marta; Perez-Toro, Olga; Bernal-Restrepo, Luz M.; Buitrago-Giraldo, Seti; Lenis-Ballesteros, Viviana; Díaz, Francisco J.

doi:10.1016/j.vaccine.2015.08.088

Cited by 9 publications

(13 citation statements)

References 35 publications

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“…Moreover, in this study almost half of children reported to share utensils and the majority of the children were enrolled from rural areas of the city. This observation is similar to a previous study in Colombia and different from another study in DRC whereby the majority of participants were from urban settings [19,25].…”

Section: Discussionsupporting

confidence: 89%

High Proportion of School Aged Children Susceptible to Mumps Virus Infections in the City of Mwanza, Tanzania: Should It be Included in the National Immunization Programme?

Rakiru

Msanga

Laisser

et al. 2020

IJTDH

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Aim: This study for the first time in Mwanza, Tanzania aimed at determining seropositivity of mumps virus in school aged children who are targeted for vaccination. Study Design: Cross-sectional study. Place and Duration of the Study: This study was conducted in the city of Mwanza from July to September 2018. Despite being common with reported associated complications in many resource limited countries, there is scarcity of information on its epidemiology in Tanzania. Methodology: We enrolled 440 school children aged 6-12 years. Data was collected using a pre-tested structured data collection tool. Blood samples were collected, and sera were used for detection of mumps virus antibodies by indirect enzyme linked immunosorbent assay (ELISA). Data was analyzed using STATA version 13, 2013. Results: The median age of enrolled children was 9(IQR: 8-11) years. The seropositivity of mumps IgG antibodies was found to be 94(21.4%, 95% CI: 17.5-25.1) while that of IgM was 1 (0.23%, 95% CI: 0.02-0.6). By multivariable logistic regression analysis, residing in rural areas (OR: 2.28, 95% 1.42-3.36, P=0.001) and age >10 years (OR: 1.67, 95% CI: 1.03-2.7, P=0.036) independently predicted mumps IgG seropositivity. Conclusion: A significant proportion of young children in urban areas of the city of Mwanza are susceptible to mumps virus infection indicating the need to generate more data across the country so as to institute appropriate control measures including measles, mumps and rubella (MMR) vaccination programme.

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Section: Discussionsupporting

confidence: 89%

High Proportion of School Aged Children Susceptible to Mumps Virus Infections in the City of Mwanza, Tanzania: Should It be Included in the National Immunization Programme?

Rakiru

Msanga

Laisser

et al. 2020

IJTDH

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“…No mumps outbreaks were reported from 2011 to 2016. Both factors are consistent with the observation that the mumps outbreak primarily affected students [15,[30][31][32]. Compared to the 2005-2006 and 2007-2010 periods, the mumps epidemiological characteristics remained unchanged from 2011-2016.…”

Section: Discussionsupporting

confidence: 88%

Assessing the Changes of Mumps Characteristics with Different Vaccination Strategies Using Surveillance Data: Importance to Introduce the 2-Dose Schedule in Quzhou of China

Zhou

Song

ZhiYing³

et al. 2020

Journal of Immunology Research

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Background. From 2005 to 2016, the prevention and control of mumps in China have undergone three stages of transition. These include the use of MuCV as a self-supported vaccine, the introduction of one-dose MMR to the Expanded Program on Immunization (EPI), and the administration of two-dose MuCV following supplementary immunization activities (SIAs) using MM. Here, using surveillance data, we assessed the epidemiology of mumps during the three stages. Methods. Children in Quzhou of China born from 2005 to 2016 and registered in the Zhejiang Provincial Immunization Information System (ZJIIS) were included. We analyzed the epidemic data and calculated incidence and MuCV coverage via birth cohorts. Results. The average incidence of mumps in 2005-2006, 2007-2010, and 2011-2016 was 51.57, 41.02, and 12.53 per 100,000 individuals, respectively. The highest incidence was in children aged 6-14 years from 2005-2016, of which the majority were school students (67.84%). Approximately 90% of the reported outbreaks occurred in school children (primary school/middle school). The seasonal characteristics of mumps were less obvious from 2011 to 2016. The coverage of one-dose MMR in the 2005 birth cohort was 71.38%. For the 2006-2010 birth cohort, the coverage of one-dose MuCV was 96.82% and the coverage of two-dose MuCV was 17.68%. The children born from 2011 to 2016 were only free vaccinated with MMR; the coverage of one-dose MuCV was 99.10%. The mumps incidence in the three birth cohorts significantly declined (X2=805.90, P<0.001 for trend). Except the children less than two years old, the mumps incidence for the children born from 2006 to 2010 was higher than that for the children born from 2011 to 2016. Conclusion. The mumps incidence significantly declined following the introduction of one-dose MMR. The SIA using MM led to a rapid reduction of mumps cases. Therefore, we recommend a two-dose MuCV routine immunization schedule and improved vaccination coverage.

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“…In Lebanon, the second dose of MMR was shifted from 5-6 years old to 18 months in 2014. An increased in the proportion of unvaccinated individuals and those vaccinated with only one dose a year after the change in the booster schedule has been described elsewhere [28]. All in all with most countries nowadays using a routine two-dose schedule but very large variation in the at the age of second dose [2], the ideal schedule for mumps vaccination in different settings is an unresolved issue which deserves major attention.…”

Section: Discussionmentioning

confidence: 95%

Effectiveness of Previous Mumps Vaccination during the 2014-2015 Outbreak in Lebanon

Haddad¹,

Naja²,

Kassouf³

et al. 2017

J Vaccines Vaccin

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Introduction: In Lebanon, MMR was introduced at 12 months and 4-5 years in 1996. In 2014, the 2nd MMR dose was shifted to 18 months. Despite a national MMR coverage estimated at 79%, a six-fold increase in mumps national incidence was observed in December 2014. The objective of this study is to determine mumps vaccine effectiveness (VE) among Lebanese population to guide immunization policies. Methods: Clinical and confirmed mumps cases reported to the Epidemiological Surveillance Program between 2014W46 and 2015W11 were eligible if they were Lebanese and aged 1.5 to 19 years-old. Controls were randomly selected controls using phonebook of the same area and matched 1:1 on age and locality. Information was collected by structured phone interviews. Mumps vaccination status was based on documented valid dates for MMR doses. Data were entered using Epidata 3 and analyzed using Stata13. VE ((1-OR) × 100) of one and two doses and ORs (95%CI) for acquiring mumps were estimated using conditional logistic regression. Results: 91 cases and 91 controls were included. Only 36% of cases had vaccination cards, compared to 71% of controls (p<0.001). 94% of cases were not vaccinated compared to 51% of controls (p<0.001). Vaccine effectiveness was estimated 60% (CI=-27%: 88%) for one dose and 88% (CI=60: 96%) for 2 doses. Conclusion: Two-doses of MMR vaccine were estimated as 88% effective against mumps, similar to results found in the literature. This outbreak can be explained by suboptimal MMR2 coverage. Efforts should focus on achieving high MMR coverage and raising population's awareness about preserving documentation of vaccination.

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Seroprevalence of mumps in an epidemic period in Medellín, Colombia

Cited by 9 publications

References 35 publications

High Proportion of School Aged Children Susceptible to Mumps Virus Infections in the City of Mwanza, Tanzania: Should It be Included in the National Immunization Programme?

High Proportion of School Aged Children Susceptible to Mumps Virus Infections in the City of Mwanza, Tanzania: Should It be Included in the National Immunization Programme?

Assessing the Changes of Mumps Characteristics with Different Vaccination Strategies Using Surveillance Data: Importance to Introduce the 2-Dose Schedule in Quzhou of China

Effectiveness of Previous Mumps Vaccination during the 2014-2015 Outbreak in Lebanon

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