Seroprevalence of parvovirus B19 infection in patients with beta thalassemia major in Fayoum University Hospital

Ghwass, Mohamed E. Al; Shafei, Shahera M. El; Mohamed, W. S.; Mohamed, Basant S.

doi:10.1016/j.epag.2016.06.002

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…Seroepidemiologic studies of several countries showed that prevalence of parvovirus B19 infection varied among countries and populations (19) . Our results was lower than a study done in Babylon city/Iraq, Their result was 30.4% positive for Anti-B19 IgG (14) , But result is in same rang with that reported by Fayoum study/Egypt (13) of 55 beta thalassemia major patient (Anti-B19 IgG is 18.2%).…”

Section: Discussioncontrasting

confidence: 56%

“…There are several studies about the seroprevelance of the virus with thalassemia patients which include Kishore study in India by ELISA (IgG) that appeared 73 (81%) from 90 (11) . Arabzadehstudy in Iran (Tehran) that resulted 4% from 70 by real-time PCR (12) Mohamed study in Egypt (Fayoum) by ELISA (IgG) that presented 18.2% from 55 (13) Same 23 Tarish study in Iraq (Babylon) by ELISA (IgG) that resulted 30.4%from 46 (14) .…”

Section: After Success Access To the Human Host Parvovirusmentioning

confidence: 99%

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Detection of Parvovirus B19 in B-thalassemia Major Patients by Serological and Molecular Method

Sadah¹,

Al-marsome²

2020

MLU

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Introduction:Because to the tropism of human parvovirus B19 to erythroid progenitor cells, infection in patients with an underlying hemolytic disorder such as Beta thalassemia major leads to suppression of erythropoiesis, referred to as reticulocytopenia,which could be life threatening, The aim of the study was to determine the rate of occurrence of parvovirus (B19) in beta thalassemia major patient by using real time-PCR, Study the correlation between B19 virus and patient's descriptive data and the correlation between B19 viral load and IgG titer.Method: This case-control study was done to detect the presence of parvovirus B19 DNA in plasma samples and anti-IgG ELISA of patients with beta thalassemia major. The population consisted of 75 patients with beta-thalassemia major who attended the Aban Al-balady hospital in in the City of Baghdad and 75 healthy people as a control. Results:The prevalence of parvovirus B19 in our study population was 28 (37.3%) were positive for B19 DNA by quantitative polymerase chain reaction in which highly significant different P value (< 0.0001), Results of enzyme linked immunosorbent assays showed that IgG antibodies was positive in 16 (21.3%) compared with control group which was 7 (9.3%). According to statistical analysis the difference was in borderline between case and control group in prevalence of B19 virus. There was significant (P= 0.039) association correlation between B19 DNA and anti-IgG positivity, but were significant in WBC (P<0.0001). Conclusion:In study, B19 infections were discovered in patients with beta thalassemia major. Screening of such risky groups will significantly reduce the incidence and prevalence of B19 infection.

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Section: Discussioncontrasting

confidence: 56%

Section: After Success Access To the Human Host Parvovirusmentioning

confidence: 99%

Detection of Parvovirus B19 in B-thalassemia Major Patients by Serological and Molecular Method

Sadah¹,

Al-marsome²

2020

MLU

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“…Prior investigations queried the factors impacting on its seroprevalence. Ghwass et al stated that the differences in B19V seroprevalence in different areas are dependant on the climate, variable socio-economic status, overpopulation, geographical, and the variety in the immunological-hematological status of patients [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

A literature review on the parvovirus B19 infection in sickle cell anemia and β-thalassemia patients

et al. 2020

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Background Parvovirus B19 is the causative agent for erythema infectiosum, and also as a potentially life-threatening infectious agent, it is mainly presented in high erythrocyte turnover patients. Sickle cell disease (SCD) is an inherited monogenic hematological disorder resulting from the mutations in the hemoglobin β-chain gene. Thalassemia is a hereditary hematological syndrome that happens in consequence of deficiencies in the production of one or more globin chains. We summarize current knowledge about the prevalence rates of the parvovirus B19 infection in sickle cell anemia and thalassemia patients. Methods Several online databases were searched including, Scopus, EMBASE, Web of Science, Google Scholar, and PubMed, which were performed amidst 2009–2019 by using distinct keywords: “Thalassemia,” “Parvovirus,” “Anemia,” “Sickle cell anemia,” “parvoviridae,” “parvoviridae infection,” and “parvovirus B19.” Results Search results indicated 4 and 7 studies for the prevalence of the parvovirus B19 in β-thalassemia and SCD, respectively. Among the β-thalassemia patients, the B19V seroprevalence for IgG and IgM were ranged from 18.2–81% and 14.5–41.1%, respectively; meanwhile, B19V DNA positively results was 4–15.3%. Moreover, in the SCD group, the extent of B19V IgG was varied from 37.6 to 65.9% and that of IgM was in a range of 2.9–30%, and the DNA detection rate was 4–54%. Conclusion B19V seroprevalence changes in several conditions including, different epidemiological features, socio-economic status, and overpopulation. Age can expand the incidence of anti-B19V IgG/IgM in SCD and beta-thalassemia patients. Reinfection and diverse genotypes are relevant factors in the seroprevalence of B19v. The patients’ immunological-hematological station and higher abundance of transfusions can affect the B19V seroprevalence in SCD and beta-thalassemia group. Further investigations in this field could be suggested to better understand the virus distribution in this susceptible population of patients.

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“…Although many studies investigated the prevalence and manifestations of HPV‐B19 infection in patients with SCA, 7,8 thalassaemia 9,10 and HS 11–13 separately, there is limited information about the extent to which HPV‐B19 infection leads to severe complications and chronic infection. There are no prospective comparative studies that have investigated the risks associated with this pathogenic virus and predicted the course of disease and morbidity among patients with HHA categorised by their underlying diseases.…”

Section: Introductionmentioning

confidence: 99%

Acute human parvovirus B19 infection triggers immune‐mediated transient bone marrow failure syndrome, extreme direct hyperbilirubinaemia and acute hepatitis in patients with hereditary haemolytic anaemias: multicentre prospective pathophysiological study

et al. 2021

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Summary A total of 244 patients with hereditary haemolytic anaemias (HHA) were screened for acute symptomatic human parvovirus B19 infection (HPV‐B19) in a prospective study. To assess the risks associated with HPV‐B19 infection, patients were classified into Group I and Group II according to presence or absence (symptoms, signs and specific serology) of acute HPV‐B19 infection respectively. In all, 131 (53·7%) patients had β‐thalassaemia, 75 (30·7%) hereditary spherocytosis (HS), 27 (11·1%) sickle cell anaemia (SCA) and 11 (4·5%) glucose‐6‐phosphate dehydrogenase (G6PD) deficiency. Of 33 (13·5%) patients who presented with symptomatic HPV‐B19 infection, 19 (57·5%) had HS, nine (27·3%) had β‐thalassaemia and five (15·2%) had SCA. In Group I, there were significant differences in the mean white blood cell, red blood cell and platelet counts, haemoglobin concentration, total bilirubin (TB), alanine aminotransferase, aspartate aminotransferase and serum creatinine (all P < 0·001) compared to Group II. In all, 27 (81·8%) patients had arthropathy and bone marrow failure (BMF); 13 (39·4%) had acute kidney injury (AKI), more in SCA (80%); and 12 (36·4%) patients had hepatitis, more in HS (66·8%). Five (15·2%) patients with HS had BMF, AKI, nervous system involvement and extreme hyperbilirubinaemia (TB range 26·3–84·7 mg/dl). Five (15·2%) patients had haemophagocytic syndrome. Two patients with HS combined with Type‐I autoimmune hepatitis presented with transient BMF. Complete recovery or stabilisation was noted at 12 months in every patient except for one patient with SCA who died during the infection. HPV‐B19 must be suspected and screened in patients with HHA with typical and atypical presentations with careful follow‐up.

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Seroprevalence of parvovirus B19 infection in patients with beta thalassemia major in Fayoum University Hospital

Cited by 4 publications

References 9 publications

Detection of Parvovirus B19 in B-thalassemia Major Patients by Serological and Molecular Method

Detection of Parvovirus B19 in B-thalassemia Major Patients by Serological and Molecular Method

A literature review on the parvovirus B19 infection in sickle cell anemia and β-thalassemia patients

Acute human parvovirus B19 infection triggers immune‐mediated transient bone marrow failure syndrome, extreme direct hyperbilirubinaemia and acute hepatitis in patients with hereditary haemolytic anaemias: multicentre prospective pathophysiological study

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