Seroprevalence of Pertussis in Adults at Childbearing Age Pre- and Post- COVID-19 in Beijing, China

Chen, Zhiyun; Pang, Jie; Zhang, Yuxiao; Ding, Yuanyuan; Chen, Ning; Zhang, Nan; He, Qiushui

doi:10.3390/vaccines10060872

Cited by 16 publications

(9 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar situations were observed in other regions, with estimated pertussis infection rates as follows: 7290/100,000 in Chongqing [ 19 ], 4573/100,000 in Ningbo [ 7 ], 9395/100,000 in Guangdong [ 25 ], 18080/100,000 in Jiangsu [ 17 ], and 6600/100,000 in the Netherlands [ 4 ]. Meanwhile, this study revealed a high susceptibility rate of 40.49% for individuals with Anti-PT-lgG <5 IU/mL, consistent with findings from multiple studies [ 17 , 18 , 28 ]. This indicates a coexistence of high infection rates and susceptibility in the population.…”

Section: Discussionsupporting

confidence: 91%

“…In this study, the susceptibility rate of women of childbearing age (15–49 years old) is as high as 54.88%, with a GMC of only 7.71 IU/mL, indicating a low level of Anti-PT-lgG in maternal antibodies. Chen et al’s study [ 28 ] found that the proportion of women of childbearing age with Anti-PT-lgG <5 IU/mL was 66.66%, 65.99%, and 70.24% in the years 2018–2020, showing an increasing trend in susceptibility. The median Anti-PT-lgG in 2020 was significantly lower than the pre-pandemic levels in 2018 and 2019.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Seroepidemiology of pertussis in Huzhou: A population-based, cross-sectional study

Liu,

Zhang,

Wang

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Purpose The resurgence of pertussis has occurred around the world. However, the epidemiological profiles of pertussis cannot be well understood by current diseases surveillance. This study was designed to understand the seroepidemiological characteristics of pertussis infection in the general population of Huzhou City, evaluate the prevalence infection of pertussis in the population, and offer insights to inform adjustments in pertussis prevention and control strategies. Methods From September to October 2023, a cross-sectional serosurvey was conducted in Huzhou City, involving 1015 permanent residents. Serum samples were collected from the study subjects, and pertussis toxin IgG antibodies (Anti-PT-IgG) were quantitatively measured using enzyme-linked immunosorbent assay (ELISA). The analysis included the geometric mean concentration (GMC) of Anti-PT-IgG, rates of GMC≥40IU/mL, ≥100IU/mL, and <5IU/mL. Stratified comparisons were made based on age, vaccination history, and human categories. Results Among the 1015 surveyed individuals, the geometric mean concentration (GMC) of Anti-PT-IgG was 10.52 (95% CI: 9.96–11.11) IU/mL, with a recent infection rate of 1.58%, a serum positivity rate of 11.43%, and a proportion with <5IU/mL of 40.49%. Among 357 children with clear vaccination history, susceptibility decreased with an increasing number of vaccine doses (Z = -6.793, P < 0.001). The concentration of Anti-PT-IgG exhibited a significant post-vaccination decline over time (Z = -5.143, P < 0.001). In women of childbearing age, the GMC of Anti-PT-IgG was 7.71 (95% CI: 6.90–8.62) IU/mL, with no significant difference in susceptibility among different age groups (χ2 = 0.545, P = 0.909). The annual pertussis infection rate in individuals aged ≥3 years was 9321 (95%CI: 3336–16039) per 100,000, with peak infection rates in the 20–29, 40–49, and 5–9 age groups at 34363 (95%CI: 6327–66918) per 100,000, 22307.72 (95%CI: 1380–47442) per 100,000, and 18020(95%CI: 1093–37266) per 100,000, respectively. Conclusions In 2023, the actual pertussis infection rate in the population of Huzhou City was relatively high. Vaccine-induced antibodies exhibit a rapid decay, and the estimated serum infection rate increases rapidly from post-school age, peaking in the 20–29 age group. It is recommended to enhance pertussis monitoring in adolescents and adults and refine vaccine immunization strategies.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Seroepidemiology of pertussis in Huzhou: A population-based, cross-sectional study

Liu,

Zhang,

Wang

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Subjects with anti-PT IgG antibodies higher than 40 IU/mL were 7.70% from the total sample (90/1169). A recent study that was conducted in China recorded positive pertussis antibodies in 1.79% in 2018, 2.04% in 2019, and finally 1.66% in 2020, respectively [27]. A cross-sectional retrospective seroprevalence study among middle-aged adults in 18 EU/EEA countries, including Greece, showed that there is circulation of B. pertussis, despite highly implemented childhood vaccination programs [28].…”

Section: Discussionmentioning

confidence: 99%

Pertussis Prevalence in Adult Population in Greece: A Seroprevalence Nationwide Study

et al. 2022

View full text Add to dashboard Cite

The reported cases of pertussis vary considerably globally. In the present nationwide study, we aimed to record the Bordetella pertussis prevalence in Greece by measuring serum IgG specific antibody levels to pertussis toxin (anti-PT IgG). General practitioners and laboratories participated in this study from 12 regions of Greece. A geographically stratified sampling plan based on regional units (NUTS level 2) was applied in order to produce a representative sample, taking into consideration age group (30–39, 40–49, 50–59, 60–69, 70–79 and 80+) and sex. In total, 1169 subjects participated in the study. The percentage of participants with anti-PT IgG antibodies higher than 50 IU/mL was 3.7%. The levels of anti-PT IgG antibodies of total sample ranged between 1.46 IU/mL to 126.60 IU/mL, with mean 17.74 IU/mL and standard deviation 14.03 U/mL (p-value < 0.001). The total seroprevalence of Greek regions for pertussis disease varied significantly among prefectures. The region with the highest seroprevalence was Peloponnese 21.3%, followed by the region of Central Greece 15.3%. The proportion of adults who have pertussis specific antibodies <50 IU/mL has been >90%, suggesting that a large number of adults may be vulnerable to infection of pertussis despite well-established vaccination programs in Greece. Despite the fact that vaccination reduced the number of reported pertussis cases in the last decades in Greece, our seroprevalence study may indicate that the herd immunity level among Greek adults is suboptimal.

show abstract

“…We used the cut-offs ≥62.5 IU/mL and ≥125 IU/mL as a pertussis infection within 12 months and 6 months, respectively, following previous studies [ 16 , 18 , 19 , 20 , 21 ] so that we can compare our results with those studies. We noted that some studies have used different cut-off values [ 23 , 40 ]; therefore, the prevalence of recent infections would differ by using different cut-off values. However, we believe that our finding of substantial circulation of B. pertussis in the community and its risk factors would not change.…”

Section: Discussionmentioning

confidence: 99%

Sero and Carriage Epidemiology of Pertussis in Urban and Rural Regions in Vietnam

Toizumi,

Le,

Nguyen

et al. 2024

Vaccines

View full text Add to dashboard Cite

The underestimation of the pertussis burden prompted our study to investigate the prevalence of recent pertussis infection, its associated factors, and antibody titer changes in the same individuals in Vietnam. Two cross-sectional surveys were conducted in Nha Trang in 2017 and Quang Ngai in 2019, representing high- and low-vaccine-coverage areas, respectively. Serum anti-pertussis toxin immunoglobulin-G (anti-PT IgG) ≥ 62.5 IU/mL by ELISA indicated infection in the previous 12 months. In Nha Trang, the participants of the 2017 survey were followed up in 2019. Logistic regression was used to determine the odds ratios for the characteristics associated with anti-PT IgG ≥ 62.5. The age-stratified prevalence in patients aged >2 years ranged from 2.1% (age 26–35) to 9.6% (3–5) in Nha Trang (2017) and from 7.2% (age 26–35) to 11.4% (6–15) in Quang Ngai. The prevalence tended to be higher in Quang Ngai across all age groups. Cough, recent antibiotic use, and smoking in Nha Trang were positively associated with an anti-PT IgG of ≥62.5, and having been diagnosed with pertussis and persistent cough with paroxysms/whoop in Quang Ngai were positively associated with an anti-PT IgG of ≥62.5. No nasopharyngeal swabs were positive for Bordetella pertussis using real-time PCR. The geometric mean of the IgG titer ratio from 2019 to 2017 was 1.45 in the paired samples. This study emphasizes Bordetella pertussis circulation across all age groups in both low- and high-vaccine-coverage settings in Vietnam, underscoring the need for continuous and standardized surveillance for a comprehensive understanding of its epidemiology.

show abstract

Seroprevalence of Pertussis in Adults at Childbearing Age Pre- and Post- COVID-19 in Beijing, China

Cited by 16 publications

References 28 publications

Seroepidemiology of pertussis in Huzhou: A population-based, cross-sectional study

Seroepidemiology of pertussis in Huzhou: A population-based, cross-sectional study

Pertussis Prevalence in Adult Population in Greece: A Seroprevalence Nationwide Study

Sero and Carriage Epidemiology of Pertussis in Urban and Rural Regions in Vietnam

Contact Info

Product

Resources

About