Seroprevalence of Rubella Antibodies among Adult Egyptian Females Aged 20-30 Years. Is there a Need for Rubella Vaccination?

Gadallah, Mohsen; Sayed, Nasr El; Kandeel, Amr; Moussa, Ibrahim; Mohsen, Amira; Dewedar, Sahar

doi:10.21101/cejph.a4010

Cited by 11 publications

(17 citation statements)

References 21 publications

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“…Our findings showed that marital status was an insignificant predictor of Rubella seropositivity. This result corroborates with the study carried out among Egyptian females [30].…”

Section: Discussionsupporting

confidence: 93%

Seroprevalence of Rubella IgM and IgG Antibodies and Associated Risk Factors among Pregnant Women Attending Antenatal Clinic at Bafoussam Regional Hospital, West Region of Cameroon

Noubom¹,

Tseyep²,

Sama³

et al. 2018

J Trop Dis

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Background: Rubella is a contagious vaccine-preventable viral infection. Its etiologic agent, Rubella virus has been identified as a human teratogen capable of causing a spectrum of birth defects known as Congenital Rubella Syndrome (CRS) if the infection occurs within the first trimester of pregnancy. Rubella continues to be a serious public health problem in developing countries. This study focused to find out the seroprevalence and risk factors associated with Rubella infection in pregnant women at the Bafoussam Regional Hospital. Materials and Methods: This was a cross-sectional study carried out among pregnant women attending the antenatal clinic. Clinicians carried out screening of 91 pregnant women for Rubella IgG and IgM antibodies from July to September 2016, using sandwich ELISA kit (SinoBiological Inc, India). A questionnaire captured known risk factors for Rubella among all participants. Risk factors for Rubella were analyzed in a binary logistic model in which not being positive for Rubella was considered the reference condition. Odd ratios calculated at 95% CI, were used to measure the strength of association between the risk factors and Rubella antibodies seropositivity. A p ≤ 0.05 was considered statistically significant. Results: Of the 91 pregnant women who accepted to participate in the study, 93.40% (85/91) were seropositive for Rubella IgM and IgG antibodies. Among the Rubella seropositive women, 87.91% (80/91), 5.49% (5/91) and 5.49% (5/91) were seropositive for IgG antibody, IgM antibody, and both IgM and IgG antibodies respectively. Among the risks factors evaluated, none was found to be an independent risk factor of Rubella infection. Conclusions: The findings from this study show that Rubella virus is circulating in the study area and more women have been and are perhaps still being exposed to this potentially hazardous childbearing age infection and there is a need to inform them on how they could protect themselves from contracting this virus.

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“…Our findings showed that marital status was an insignificant predictor of Rubella seropositivity. This result corroborates with the study carried out among Egyptian females [30].…”

Section: Discussionsupporting

confidence: 93%

Seroprevalence of Rubella IgM and IgG Antibodies and Associated Risk Factors among Pregnant Women Attending Antenatal Clinic at Bafoussam Regional Hospital, West Region of Cameroon

Noubom¹,

Tseyep²,

Sama³

et al. 2018

J Trop Dis

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“…Also, Olajide et al, 19 registered the illiterate and primary school females showing completely (100%) IgG-positive while the secondary and tertiary ranging from 90% to 93.2%. Conversely, Gadallah et al, 22 illustrated the university grade and primary to secondary school individuals show nearly similar antirubella prevalence and no significant differences. The variation in previous results to this result may be referred to as many factors that play a minor role in rubella virus infection.…”

Section: Discussionmentioning

confidence: 94%

“…The incidence of rubella infection through the first trimester or second trimester represents a risk for the developing fetus resulting in congenital rubella syndrome Conversely, a study by Sallam et al,8 observed that the participants from the rural area had a higher prevalence rate of rubella IgG antibody than the urban area. Also, Gadallah et al, 22 noticed that the participants belong to a rural area having a high rate than participated women coming from an urban area. Olajide et al, 19 found that the prevalence rate of rubella IgG was 93.8% and 90.3% in urban and rural areas, respectively.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Rubella Igg Antibodies Among Productive-Age ‎women in Al-Mahweet Governorate, Yemen

et al. 2020

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Background: Rubella is an infectious viral disease that caused by the Rubella virus. The incidence of rubella infection in women during pregnancy leads to complications for fetus development and cause congenital rubella syndrome or fetal death. This study aimed to determine the prevalence rate of rubella among reproductive-age women in Al-Mahweet, Yemen. Methods: A cross sectional study was conducted among females attending healthcare centers and schools from July 2007 to June 2008. Blood samples were collected individually from 270 females aged 15-35 years and the rubella virus IgG antibody was quantitated by enzyme-linked immunosorbent assay (ELISA). The needed data were collected by using a pretested questionnaire and analyzed by statistical program. Results: Overall, 197(73%) had IgG-positive antibody to rubella and 73(27%) had IgG-negative antibody to rubella. The highest rate of anti-rubella IgG was among females aged 15-25 years and the lowest was among the females aged 31-35 years. Similarly, the higher rate was among females living in urban area compared to females from rural area. The statistically significant difference was found between most educational levels and positive results of anti-rubella IgG. With regard to marital status, the most frequent of rubella antibody was 72.3%, 73.1%, and 75.0%, respectively, recorded among single, married, and divorced females. The non-pregnant women had (73.7%) more incidence to rubella IgG antibody than pregnant (66.7%). 82.2% of IgG- positive women had no history of stillbirth and 65% had a history of stillbirth. Conclusions: Most of the enrolled females had immunity against rubella virus, but still a significant percentage were susceptible to rubella infection. Thus, it is essential to introduce of rubella vaccine to control and prevent the rubella virus circulating among the community. Peer Review History: Received 20 July 2020; Revised 11 August; Accepted 22 August, Available online 15 September 2020 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Name: Dr. (Mrs) Amaka A. Mgbahurike Affiliation: University of PortHarcourt, Nigeria E-mail: amaka_mgbahurike@yahoo.com Name: Dr. Tamer Elhabibi Affiliation: Egyptian Russian University, Egypt E-mail: Tamer_elhabibi@yahoo.com Name: Rawaa S. Al-Kayali Affiliation: Aleppo university, biochemistry and microbiology department, Syria E-mail: Rawah67@hotmail.com Name: Rola jadallah Affiliation: Arab American University, Palestine E-mail: rolla.jadallah@aaup.edu Comments of reviewer(s): Similar Articles: THE ASSOCIATION OF EPSTEIN-BARR VIRUS ANTIBODIES WITH RHEUMATOID ARTHRITIS AMONG YEMENI PATIENTS IN SANA’A CITY SEROPREVALENCE OF ANTI-MANNOSE BINDING LECTIN AUTOANTIBODIES IN PATIENTS WITH RHEUMATOID ARTHRITIS IN SANA'A CITY- YEMEN

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“…Concerning history of rubella infection, the existing study report that 2.3% of pregnant women had a history of rubella infection, but Esposito et al, [15] found the percent was 15% this difference come from the group of people that the study applied on, as this study performed on pregnant women only, but Mohsen et al [16] accomplished his study on all female aged from 20-30 years in Egypt. In addition, there was relation between pre test score of knowledge and history of rubella in previous pregnancy.…”

Section: Discussionmentioning

confidence: 85%

Educational program about Rubella among pregnant women attending antenatal clinic in Women’s Health Hospital, Assiut University, Egypt

Ibrahim

Khalaf²,

Khalek³

2018

JNEP

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Background and objective: Rubella or German measles is infectious disease that affects both child and adult, but when associated with pregnancy, especially in first trimester, fetus can be exposed to various problems as abortion, multiple birth defects, and congenital rubella syndrome (CRS). This study aimed to assess awareness of pregnant women about rubella and to identify the impact of an educational program about rubella for pregnant women attending antenatal outpatient clinic in Women’s Health Hospital, Assiut University, Egypt.Methods: Quasi-experimental research design was carried out included 300 pregnant women in their first trimester. Direct interview using a semi-structured questionnaire which involved two parts: part (1) included personal data, family, and medical history, and part (2) involved questions directed to pregnant women to assess their knowledge about rubella. An educational program was applied on women as an intervention by session meeting classes. The data of knowledge were collected after the intervention then analyzed.Results: More than one third (38%) of the studied pregnant women were 25-30 years. The mean score of knowledge regarding rubella among pregnant women was 5.83 ± 2.48 in the pretest which improved significantly in the posttest to 20.07 ± 1.86.Conclusions and recommendations: The results revealed lack of awareness regarding rubella among studied women which increased after the application of the educational program. It is important to increase the availability of antenatal care services and provide adequate counseling for women before pregnancy about Rubella infection.

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Seroprevalence of Rubella Antibodies among Adult Egyptian Females Aged 20-30 Years. Is there a Need for Rubella Vaccination?

Cited by 11 publications

References 21 publications

Seroprevalence of Rubella IgM and IgG Antibodies and Associated Risk Factors among Pregnant Women Attending Antenatal Clinic at Bafoussam Regional Hospital, West Region of Cameroon

Seroprevalence of Rubella IgM and IgG Antibodies and Associated Risk Factors among Pregnant Women Attending Antenatal Clinic at Bafoussam Regional Hospital, West Region of Cameroon

Prevalence of Rubella Igg Antibodies Among Productive-Age ‎women in Al-Mahweet Governorate, Yemen

Educational program about Rubella among pregnant women attending antenatal clinic in Women’s Health Hospital, Assiut University, Egypt

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