Seroprevalence of rubella in the cord blood of pregnant women and congenital rubella incidence in Nha Trang, Vietnam

Miyakawa, Masami; Yoshino, Hiroshi; Yoshida, Lay‐Myint; Vynnycky, Emilia; Motomura, Hideki; Tho, Le Huu; Thiem, Vu Dinh; Ariyoshi, Koya; Anh, Đặng Đức; Moriuchi, Hiroyuki

doi:10.1016/j.vaccine.2013.08.076

Cited by 31 publications

(42 citation statements)

References 13 publications

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“…The number of CRS cases in this study was comparable to the findings of previous epidemic reports from Oman, Ghana, Panama, and Russia (0.7, 0.8, 2.2, and 3.5 per 1000 live births during epidemics, respectively), 21,[24][25][26] and a CRS incidence of 2.3 (95% CI, 2.1-2.6) cases per 1000 live births in Vietnam estimated by modeling. 6 Unfortunately, hemodynamic status in each patient was not precisely recorded. Heart rates, respiratory rates, and oxygen saturation were recorded only at enrollment.…”

Section: Figurementioning

confidence: 99%

“…We found that 29% (95% confidence interval [CI], 27%-31%) of enrolled pregnant females were rubellaspecific immunoglobulin G (IgG) antibodynegative and susceptible to rubella. 6 After that study was conducted, a large-scale rubella outbreak occurred between January and July 2011 throughout Vietnam (H.T.N. et al, unpublished observations), and many CRS cases emerged.…”

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confidence: 99%

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Mortality Associated With Pulmonary Hypertension in Congenital Rubella Syndrome

Toizumi

Motomura

et al. 2014

Pediatrics

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OBJECTIVE: Outbreaks of rubella and congenital rubella syndrome (CRS) continue to arise in various countries where a rubella-containing vaccine is not included in the national immunization program. After a large-scale rubella outbreak in 2011, CRS cases emerged in Vietnam. The aim of this study was to clarify the clinical features of these cases with an emphasis on cardiovascular complications and outcomes. METHODS: From October 2011 to September 2012, we conducted a prospective surveillance study of infants <12 months of age who had manifestations suggesting CRS at the only referral hospital in Khanh Hoa Province. These infants underwent standard examinations, echocardiography, cranial ultrasonography, automated auditory brainstem responses, blood cell count measurements, and rubella-specific antibody testing. Detected cardiovascular defects were regularly followed with echocardiography. RESULTS: We enrolled 38 cases of CRS characterized by a low birth weight (71%), cardiovascular defects (72%), cataracts (13%), hearing impairment (93%), purpura (84%), hepatosplenomegaly (68%), and thrombocytopenia (76%). Patent ductus arteriosus, the most common cardiovascular complication, was often associated with progressive pulmonary hypertension (PH). As of January 2013, 13 infants (34%) had died, and PH was significantly more frequent among the fatalities (P = .004); however, therapeutic closure of the ductus reversed the PH in several cases. CONCLUSIONS: PH-associated mortality is high among infants who have CRS in Vietnam. Providing proper assessments, continuous follow-up, and timely intervention for cardiovascular defects is critical for the management of CRS patients. Echocardiography is of diagnostic and prognostic value and can support better clinical management of CRS, even in a developing country setting.

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Section: Figurementioning

confidence: 99%

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confidence: 99%

Mortality Associated With Pulmonary Hypertension in Congenital Rubella Syndrome

Toizumi

Motomura

et al. 2014

Pediatrics

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“…However, infection with rubella virus in the first trimester of pregnancy may lead to miscarriage, stillbirth or a child born with congenital rubella syndrome (CRS). CRS is one of the greatest risks to newborn infants and may entail a variety of birth defects, such as sensor-ineural deafness, cataracts, and cardiac defects (1,2). Therefore, in 2000, the World Health Organization (WHO) recommended the use of the rubella-containing vaccine (RCV) in all national childhood immunization schedules to prevent congenital rubella infection, including CRS (3).…”

Section: Introductionmentioning

confidence: 99%

Rubella Seroprevalence among the General Population in Dongguan, China

et al. 2015

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SUMMARY:In order to assess the immunity to rubella infection in Dongguan, China, we conducted a seroprevalence survey on rubella and used ELISA to measure rubella-specific IgG in serum samples. A total of 1,017 individuals aged 0-59 years were selected by multistage cluster sampling. Among them, 904 (88.9z) were seropositive for rubella. Two groups (20-29 and 40 years) had seropositivity rates of ＜90z. In comparison with participants aged 20 years, rubella immunization rates were higher in those aged ＜20 years (83.2z vs. 93.7z, respectively; x 2 ＝ 28.063, P ＜ 0.001). Among women aged 20-29 years, only 63.8z had antibodies above the protective level. Multivariate analysis revealed that only sex and age were significantly associated with rubella-protective antibody levels. Our results suggest that in the study area, women of childbearing age had a greater serological susceptibility to rubella. Additional vaccinations for rubella of susceptible young adults should be considered, particularly in women of childbearing age.

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“…The access of microorganisms to the embryo before parturition causes the inflammatory response syndrome of the fetus against producing microbial products leading to premature labor. The consequences are multiple organ dysfunction syndrome (MODS) in the embryo and an increase in the mortality rate of the fetus (9). The results of this study showed that viral and parasitic bodies (Cytomegalovirus, Toxoplasma, and Rubella) are significantly evident and available in the blood serum of women.…”

Section: Discussionmentioning

confidence: 83%

“…The virus has the ability to transfer from placenta to fetus, and the risk of infecting the fetus depends on the age of the fetus when the mother is infected. The risk of abnormalities in the fetus in the first 12 weeks of pregnancy is 85% and after 16 weeks, it reaches the lowest point (9,10).…”

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confidence: 99%

Association of Rubella, Cytomegalovirus, and Toxoplasma Infections with Recurrent Miscarriages in Bonab-Iran: A Case-Control Study

et al. 2017

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Background: Recurrent miscarriage is defined as a condition with two or more consecutive abortions before the 20 weeks of gestation. Recurrent miscarriage is a multi-factorial disease, which occurs in approximately 1% -2% of women at the reproductive age. Congenital infection is one of the most important factors in the recurrent miscarriages. Objectives: The aim of this study was to investigate the effects of rubella, cytomegalovirus, and toxoplasma infections on recurrent miscarriage in Bonab county. Methods: This is a case-control study. Blood samples from a total of 100 women with recurrent miscarriage and 100 healthy women aged 20 to 35 years were taken and serum were separated. Antibodies against Rubella, Cytomegalovirus, and Toxoplasma were read by direct enzyme-linked immunosorbent assay (ELISA). Finally, data were statistically analyzed. Results: A total of 31 patients and 14 controls were positive for IgG antibodies against Toxoplasma. In addition, 27 persons in the patient group and 11 in the control group were positive for the presence of IgG antibodies against Cytomegalovirus. A total of 29 patients and 11 controls were positive for IgG antibodies against Rubella. Conclusion: In this study, there was a significant difference in the prevalence of anti-Rubella, Cytomegalovirus, and Toxoplasma antibodies between women with recurrent miscarriage and healthy women.

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Seroprevalence of rubella in the cord blood of pregnant women and congenital rubella incidence in Nha Trang, Vietnam

Cited by 31 publications

References 13 publications

Mortality Associated With Pulmonary Hypertension in Congenital Rubella Syndrome

Mortality Associated With Pulmonary Hypertension in Congenital Rubella Syndrome

Rubella Seroprevalence among the General Population in Dongguan, China

Association of Rubella, Cytomegalovirus, and Toxoplasma Infections with Recurrent Miscarriages in Bonab-Iran: A Case-Control Study

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