Seroprevalence of rubella-specific IgM and IgG antibodies among pregnant women in a Catholic Hospital in Yaoundé, Cameroon

Eno, Anna; Makemgue, Louise Stéphanie; Tonye, Daves Stéphane; Boye, Cheikh Saad Bouh; Seck, Abdoulaye; Bercion, Raymond; Fellous, Christelle Vauloup; Tchuenté, L. A. Tchuem

doi:10.4314/ijbcs.v12i3.4

Cited by 3 publications

(2 citation statements)

References 7 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reports from various countries showed the prevalence of rubella among schoolgirls, pregnant women and women at productive age (child bearing age). [13][14][15][18][19][20][21][22] In the current study, there was no statistically significant difference between the rate of rubella virus antibodies and residence age, socioeconomic status, education levels, abortion time, congenital defects and symptoms. On the other hand, there was a significant between rubella IgG antibody and a previous number of abortions.…”

Section: Discussioncontrasting

confidence: 60%

Estimation of Rubella virus antibodies among aborted women in Ibb City-Yemen

Abbas¹,

Moharam²,

Al-Gmashi³

et al. 2023

JHVRV

View full text Add to dashboard Cite

German measles is a public health disease caused by rubella virus resulting in adverse consequences among pregnant women as congenital rubella syndrome (CRS) including abortions. Abortion is one of the most common health problems in the world. So, this study purposed to estimate prevalence of rubella virus antibodies among aborted women in Ibb city, Yemen. A cross-sectional investigation was accomplished from January 2022 to June 2022. 150 serum samples were collected from aborted women attending the obstetrics and gynecology department of various hospitals to analyze rubella virus IgG and IgM antibodies by Electro-Chemiluminescence Immunoassay (ECLIA). Demographical and clinical features were collected using a questionnaire. The data were analyzed using GraphPad software and P values ≤0.05 were considered statistically significant. With regards to the prevalence of rubella virus antibodies among aborted women, 149 cases (99.3%) of aborted women were rubella IgG antibodies positive. Rubella virus IgM antibodies were negative (100%) in all aborted women. The prevalence of rubella virus IgG antibodies in the age 26-30 was less than in other age groups. Moreover, the seroprevalence of rubella virus IgG was higher in rural aborted women (100%) compared to urban ones. Demographical and clinical features among aborted women were not statistically significant concerning rubella IgG positive results. In conclusion, the low rate of rubella IgM and a high proportion of rubella IgG for the most aborted women in this study suggest that rubella infection might indicate a previous infection.

show abstract

Section: Discussioncontrasting

confidence: 60%

Estimation of Rubella virus antibodies among aborted women in Ibb City-Yemen

Abbas¹,

Moharam²,

Al-Gmashi³

et al. 2023

JHVRV

View full text Add to dashboard Cite

show abstract

“…Though not statistically evaluated, it is expected that prevalence rates will be less in rural than urban settings due to crowding [26]. Some studies in pregnant women from hospital settings in Nigeria and Cameroon have also shown low prevalence rates, 3.9, 5.0, 1.84, 1.25% [14,23,25,27], while others have reported relatively high rates 38.8%, and 16.3%, and 10.1% [9,28,29]. The high prevalence rates may be accounted for by possible outbreaks which may have resulted in both new and re-infections [9], the possibility of false positives should however not be discounted.…”

Section: Discussionmentioning

confidence: 99%

Rubella virus IgM and IgG antibodies with avidity in pregnant women and outcomes at a tertiary facility in Ghana

et al. 2022

View full text Add to dashboard Cite

Background Congenital rubella syndrome (CRS) is a recognised cause of childhood deafness and blindness caused by the transplacental transmission of rubella virus during pregnancy. Women in the reproductive age group, and by extension their unborn babies may therefore be at increased risk. The prevalence of Rubella virus specific IgM and IgG antibodies, including IgG avidity, was determined in pregnant women attending the antenatal clinic at a Teaching Hospital in Ghana. Methods One hundred and forty-five women in their second and third trimesters of pregnancy from the outpatient clinic were recruited over a period of 2 months after written informed consent was obtained. Study participants completed a questionnaire and venous blood drawn for IgM, IgG, and avidity testing using SERION ELISA (SERION® Immunologics, Würzburg, Germany). Babies of mothers with positive or indeterminate IgM and low avidity IgG antibodies were offered specialist cardiological, ophthalmological or hearing assessment during follow up. Results One hundred and twenty-eight (88.3%) had only IgG antibodies, 5 (3.4%) had IgM and IgG antibodies, while 12 (8.3%) had no antibodies. No patient had IgM antibodies alone. Ten women (6.9%) had indeterminate levels of IgM antibodies. Majority of the women had high avidity IgG antibodies, while 5 (3.4%) had low avidity antibodies. No patient had IgM with low avidity antibodies. There was no statistical association between socio-demographic factors and the presence of IgM, IgG (low or high avidity) antibodies. Of all the children followed, none had the clinical definition of CRS. Conclusions Consistent with the World Health Organization elimination strategy for measles and rubella viruses, non-immune women in the reproductive age group should be vaccinated. The immunization programme should be expanded to include teenagers and adults. Though Congenital Rubella Syndrome was not detected, the risk still remains.

show abstract