Seroprevalence of SARS-CoV-2 antibodies among physicians from a children’s hospital

Insúa, Claudia; Stedile, Graciela; Figueroa, Verónica; Hernández, Claudia; Svartz, Alejandra; Ferrero, Fernando; Ossorio, María Fabiana; Brunetto, Oscar

doi:10.5546/aap.2020.eng.381

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…Due to the fact that official case counts are based on tests carried out in symptomatic individuals and the absence of seroprevalence data from population-based studies in Argentina, the actual number of people who have been infected with SARS-CoV-2 is probably underestimated ( 8 , 9 ). In this context, this is the first reported research in Argentina including general population, providing a regional estimation of the presence of anti-SARS-CoV-2 IgG antibodies in asymptomatic and pauci-symptomatic people over a full 5-month period of the pandemic.…”

Section: Discussionmentioning

confidence: 99%

“…Since the beginning of the social isolation as a mandatory preventive health-policy in March 2020, until December 20 th , the province accumulated a total of 130 000 laboratory-confirmed cases that were tested because of being symptomatic ( 7 ). Nevertheless, in the region and even at the national level, data from population-based seroprevalence studies have not yet been reported, so the real infection rate is probably underestimated ( 8 , 9 ).…”

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confidence: 99%

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Seroprevalence of anti-SARS-CoV-2 IgG in asymptomatic and pauci-symptomatic people over a 5 month survey in Argentina

Rodeles

Peverengo

Benítez

et al. 2021

Revista Panamericana De Salud Pública

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Objective. To evaluate the seroprevalence of COVID-19 infection in pauci-symptomatic and asymptomatic people, the associated epidemiological factors, and IgG antibody kinetic over a 5-month period to get a better knowledge of the disease transmissibility and the rate of susceptible persons that might be infected. Methods. Seroprevalence was evaluated by a cross-sectional study based on the general population of Santa Fe, Argentina (non-probabilistic sample) carried out between July and November 2020. A subgroup of 20 seropositive individuals was followed-up to analyze IgG persistence. For the IgG anti-SARS-CoV-2 antibodies detection, the COVID-AR IgG® ELISA kit was used. Results. 3 000 individuals were included conforming asymptomatic and pauci-symptomatic groups (n=1 500 each). From the total sample, only 8.83% (n=265) presented reactivity for IgG anti-SARS-CoV-2. A significant association was observed between positive anti-SARS-CoV-2 IgG and a history of contact with a confirmed case; the transmission rate within households was approximately 30%. In the pauci-symptomatic group, among the seropositive ones, anosmia and fever presented an OR of 16.8 (95% CI 9.5-29.8) and 2.7 (95% CI 1.6-4.6), respectively (p <0.001). In asymptomatic patients, IgG levels were lower compared to pauci-symptomatic patients, tending to decline after 4 months since the symptoms onset. Conclusion. We observed a low seroprevalence, suggestive of a large population susceptible to the infection. Anosmia and fever were independent significant predictors for seropositivity. Asymptomatic patients showed lower levels of antibodies during the 5-month follow-up. IgG antibodies tended to decrease over the end of this period regardless of symptoms.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Seroprevalence of anti-SARS-CoV-2 IgG in asymptomatic and pauci-symptomatic people over a 5 month survey in Argentina

Rodeles

Peverengo

Benítez

et al. 2021

Revista Panamericana De Salud Pública

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“…Many studies have examined seroprevalence among HCWs. For example, some studies from different countries have reported low seroprevalence of COVID-19 in HCWs who work in pediatric hospitals [ 7 , 8 ], tertiary hospitals [ 9 , 10 ], university or academic hospitals [ 11 , 12 ] and emergency HCWs [ 13 ]. Some studies show that measurement of seroprevalence in SARS-CoV-2 in frontline HCWs can give highly varied results based on the country or region of testing, healthcare role and when testing was carried out [ 14 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of anti-SARS-CoV-2 antibodies among staff at primary healthcare institutions in Prishtina

Halili¹,

Bunjaku²,

Gashi³

et al. 2022

BMC Infect Dis

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Background Many studies examined the spread of SARS-CoV-2 within populations using seroprevalence. Healthcare workers are a high-risk population due to patient contact, and studies are needed to examine seroprevalence of SARS-CoV-2 antibodies among healthcare workers. Our study investigates the seroprevalence of anti-SARS-CoV-2 antibodies among staff at primary healthcare institutions in Prishtina, and factors associated with seroprevalence. Methods We carried out a cross-sectional survey including SARS-CoV-2 serological testing and questionnaires with primary healthcare workers from primary healthcare facilities in the Prishtina, the capital city of Kosovo. We calculated prevalence of anti-SARS-CoV-2 antibodies, and of self-reported positive PCR test among primary healthcare workers, as well as crude and adjusted ORs for explanatory factors. Results Eighty-three of the healthcare workers (17.47%) tested positive for SARS-CoV-2 antibodies IgG or IgM, while 231 (48.63%) either had antibodies or a previous positive PCR test. Odds of seropositivity were affected by male gender (OR 2.08, 95% CI 1.20, 3.61), and infected family members (OR 3.61, 95% CI 2.25, 5.79) of healthcare workers. Higher education, being part of larger families and having infected family members gave higher odds of positive PCR test and seropositivity. Other healthcare workers had lower odds of positive PCR test and seropositivity than physicians. Conclusion Over 17% of healthcare workers were seropositive for SARS-CoV-2 antibodies and close to half of them were either seropositive or PCR self-reported positive test. Several factors are associated with decreased and increased odds for such outcomes. These findings should be explored further and addressed to Kosovo policy makers, and assist them to intensify vaccination efforts, and maintain control measures until we achieve herd immunity.

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“…There have been several studies examining the prevalence of SARS-CoV-2 and the seroprevalence of IgM/IgG antibodies in HCWs compared to community levels, and results are varied [ 4 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Though there have been fewer studies of pediatric HCWs to date, rates of positive serology in pediatric HCWs have consistently been found to be lower or equal to those measured in the general population, with the reported range of positive serology ranging from 0–16.9% [ 5 , 6 , 7 , 8 , 9 , 19 , 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 Serology Testing in an Asymptomatic, At-Risk Population: Methods, Results, Pitfalls

Heyming

Bacon

Lara

et al. 2021

Infectious Disease Reports

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The primary aim of this study was to determine the seroprevalence of SARS-CoV-2 antibodies in a population of pediatric healthcare workers (HCWs). This study was conducted 14 May–13 July 2020. Study participants included pediatric HCWs at a pediatric hospital with either direct patient contact or close proximity to patient-care areas. SARS-CoV-2 antibodies were assessed via the Wytcote Superbio SARS-CoV-2 IgM/IgG Antibody Fast Detection Kit and the Abbott Architect SARS-CoV-2 IgG assay. Participants underwent RT-PCR testing upon entry to the study and following rapid IgM+/IgG+ results; respiratory panel PCR (RP-PCR) was performed following IgM+ results. A total of 57 of 289 (19.7%) of participants demonstrated positive serology as assessed by the Wytcote rapid kit (12 on Day 1 and 45 throughout the study). However, only one of these participants demonstrated IgG+ serology via the Abbott assay. Two participants tested SARS-CoV-2+ via RT-PCR testing. One individual was adenovirus+ and enterovirus/rhinovirus+. In our study population, we observed a seroprevalence of SARS-CoV-2 antibodies of 0.35%. The lack of concordance between antibody tests suggests that the Wytcote rapid test kit may not be of use as a screening tool. However, the feasibility of the overall process indicates that a similar methodology may have potential for future epidemiologic surveillance.

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Seroprevalence of SARS-CoV-2 antibodies among physicians from a children’s hospital

Cited by 7 publications

References 11 publications

Seroprevalence of anti-SARS-CoV-2 IgG in asymptomatic and pauci-symptomatic people over a 5 month survey in Argentina

Seroprevalence of anti-SARS-CoV-2 IgG in asymptomatic and pauci-symptomatic people over a 5 month survey in Argentina

Seroprevalence of anti-SARS-CoV-2 antibodies among staff at primary healthcare institutions in Prishtina

SARS-CoV-2 Serology Testing in an Asymptomatic, At-Risk Population: Methods, Results, Pitfalls

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