Seroprevalence of SARS-CoV-2 Antibodies Among Children in School and Day Care in Montreal, Canada

Zinszer, Kate; McKinnon, Britt; Bourque, Noémie; Pierce, Laura; Saucier, Adrien; Otis, Alexandra; Cheriet, Islem; Papenburg, Jesse; Hamelin, Marie‐Ève; Charland, Katia; Carbonneau, Julie; Zahreddine, Monica; Savard, Ashley; Fortin, Guy; Apostolatos, Alexander; Haley, Nancy; Ratté, Nathalie; Laurin, I; Nguyen, Cat Tuong; Conrod, Patrica; Boivin, Guy; Serres, Gaston De; Quach, Caroline

doi:10.1001/jamanetworkopen.2021.35975

Cited by 40 publications

(41 citation statements)

References 34 publications

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“…In this study, higher seroprevalence in those with a history of laboratory-confirmed COVID-19 was not observed. However, only 2.4% of the participants had a known history of COVID-19, a finding which agrees with previous studies suggestive of a significantly higher frequency of asymptomatic infections and undertesting in children than in adults [ 21 , 22 ]. A population-based study in Geneva also observed lower seroprevalence rates among younger (6–9 years old) children [ 23 ].…”

Section: Discussionsupporting

confidence: 89%

Seroprevalence of immunoglobulin G antibodies against SARS-CoV-2 in children and adolescents in Delhi, India, from January to October 2021: a repeated cross-sectional analysis

Sharma¹,

Basu²,

Mishra³

et al. 2022

PHRP

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Objectives: The aim of this study was to assess changes in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) seroprevalence among children and adolescents in Delhi, India from January 2021 to October 2021Methods: This was a repeated cross-sectional analysis of participants aged 5 to 17 years from 2 SARS-CoV-2 seroprevalence surveys conducted in Delhi, India during January 2021 and September to October 2021. Anti-SARS-CoV-2 IgG antibodies were detected by using the VITROS assay (90% sensitivity, 100% specificity).Results: The seroprevalence among 5- to 17-year-old school-age children and adolescents increased from 52.8% (95% confidence interval [CI], 51.3%−54.3%) in January 2021 to 81.8% (95% CI, 80.9%−82.6%) in September to October 2021. The assay-adjusted seroprevalence was 90.8% (95% CI, 89.8%−91.7%). Seropositivity positively correlated with participants’ age (p<0.001), but not sex (p=0.388). A signal to cut-off ratio ≥4.00, correlating with the presence of neutralization antibodies, was observed in 4,814 (57.9%) participants.Conclusion: The high percentage of seroconversion among children and adolescents indicates the presence of natural infection-induced immunity from past exposure to the SARS-CoV-2 virus. However, the lack of hybrid immunity and the concomitant likelihood of lower levels of neutralization antibodies than in adults due to the absence of vaccination warrants careful monitoring and surveillance of infection risk and disease severity from newer and emergent variants.

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Section: Discussionsupporting

confidence: 89%

Seroprevalence of immunoglobulin G antibodies against SARS-CoV-2 in children and adolescents in Delhi, India, from January to October 2021: a repeated cross-sectional analysis

Sharma¹,

Basu²,

Mishra³

et al. 2022

PHRP

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“…Since the start of the COVID-19 pandemic, it has become apparent that pediatric populations are less affected than adult or older populations (1,2), although studies have also found children and adults to be infected to a similar low degree (3). Clinical presentation of SARS-CoV-2 infection is milder in children, with more proportion of asymptomatic cases (1,(4)(5)(6). One hypothesis for this lower severity of COVID-19 is the protective effect that antibodies from human coronaviruses of the common cold (HCoV), which are more prevalent in children, could exert on SARS-CoV-2 control, considering cross-reactivity between them (7,8).…”

Section: Introductionmentioning

confidence: 99%

Multiplex Antibody Analysis of IgM, IgA and IgG to SARS-CoV-2 in Saliva and Serum From Infected Children and Their Close Contacts

et al. 2022

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COVID-19 affects children to a lesser extent than adults but they can still get infected and transmit SARS-CoV-2 to their contacts. Field deployable non-invasive sensitive diagnostic techniques are needed to evaluate the infectivity dynamics of SARS-CoV-2 in pediatric populations and guide public health interventions, particularly if this population is not fully vaccinated. We evaluated the utility of high-throughput Luminex assays to quantify saliva IgM, IgA and IgG antibodies against five SARS-CoV-2 spike (S) and nucleocapsid (N) antigens in a contacts and infectivity longitudinal study in 122 individuals (52 children and 70 adults). We compared saliva versus serum/plasma samples in infected children and adults diagnosed by weekly RT-PCR over 35 days (n=62), and those who consistently tested negative over the same follow up period (n=60), in the Summer of 2020 in Barcelona, Spain. Saliva antibody levels in SARS-CoV-2 RT-PCR positive individuals were significantly higher than in negative individuals and correlated with those measured in sera/plasmas. Asymptomatic infected individuals had higher levels of anti-S IgG than symptomatic individuals, suggesting a protective anti-disease role for antibodies. Higher anti-S IgG and IgM levels in serum/plasma and saliva, respectively, in infected children compared to infected adults could also be related to stronger clinical immunity in them. Among infected children, males had higher levels of saliva IgG to N and RBD than females. Despite overall correlation, individual clustering analysis suggested that responses that may not be detected in blood could be patent in saliva, and vice versa.In conclusion, measurement of SARS-CoV-2-specific saliva antibodies should be considered as a complementary non-invasive assay to serum/plasma to determine COVID-19 prevalence and transmission in pediatric populations before and after vaccination campaigns.

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“…Both calculations are based on power of 80% and a two-sided significance level of 95%. Using the eligible student populations of the sampled primary and secondary schools, we require response rates of 6% and 28% among parents and adolescents, respectively, which are reasonable targets based on our previous COVID-19 research in Montreal schools 31…”

Section: Methods and Analysismentioning

confidence: 99%

Using human-centred design to tackle COVID-19 vaccine hesitancy for children and youth: a protocol for a mixed-methods study in Montreal, Canada

et al. 2022

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IntroductionTo successfully combat COVID-19 vaccine hesitancy and increase uptake, research has demonstrated that interventions are most effective when tailored to meet local needs through active engagement and co-development with communities. This mixed-methods project uses a human-centred design (HCD) approach to understand local perspectives of COVID-19 vaccine hesitancy and develop strategies to enhance vaccine confidence for children and adolescents.Methods and analysisProject ECHO (Étude Communautaire sur l’Hésitation vaccinale contre la COVID-19) combines population-based surveys of parents and adolescents with community-based participatory action research to design and pilot strategies to enhance COVID-19 vaccine confidence in two underserved and ethnoculturally diverse neighbourhoods of Montreal, Canada. Two surveys conducted 6 months apart through primary and secondary schools are used to monitor vaccine acceptance and its social determinants among children and youth. Analyses of survey data include descriptive and inferential statistical approaches. Community-led design teams of parents and youth from the two participating neighbourhoods, supported by academic researchers, design thinking experts and community partners, use an HCD approach to: (1) gather data to understand COVID-19 vaccine decision-making among parents and youth in their community and frame a design challenge (inspiration phase); (2) develop an intervention to address the design challenge (ideation phase) and (3) pilot the intervention (implementation phase). Strategies to evaluate the community-led interventions will be co-developed during the implementation phase.Ethics and disseminationThis study has been approved by the research ethics boards of the Sainte-Justine University Hospital Centre and the University of Montreal. Community design teams will be involved in the dissemination of findings and the design of knowledge translation initiatives that foster dialogue related to COVID-19 vaccination for children and adolescents among community, school and public health stakeholders. Findings will be disseminated through peer-reviewed publications, conference presentations, community forums, policy briefs, and social media content.

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Seroprevalence of SARS-CoV-2 Antibodies Among Children in School and Day Care in Montreal, Canada

Cited by 40 publications

References 34 publications

Seroprevalence of immunoglobulin G antibodies against SARS-CoV-2 in children and adolescents in Delhi, India, from January to October 2021: a repeated cross-sectional analysis

Seroprevalence of immunoglobulin G antibodies against SARS-CoV-2 in children and adolescents in Delhi, India, from January to October 2021: a repeated cross-sectional analysis

Multiplex Antibody Analysis of IgM, IgA and IgG to SARS-CoV-2 in Saliva and Serum From Infected Children and Their Close Contacts

Using human-centred design to tackle COVID-19 vaccine hesitancy for children and youth: a protocol for a mixed-methods study in Montreal, Canada

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