Seroprevalence of SARS-Cov-2 Antibodies in Adults, Arkhangelsk, Russia

Krieger, E. A.; Kudryavtsev, Alexander; Sharashova, Ekaterina; Postoev, Vitaly Alexandrovich; Belova, Natalia; Shagrov, Leonoid; Zvedina, Julia; Драпкина, О. М.; Kontsevaya, А. V.; Шальнова, С. А.; Brenn, Tormod; Shkolnikov, Vladimir M.; Eggo, Rosalind M; Leon, David A.

doi:10.3201/eid2802.211640

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…Полученная в ЭССЕ-РФ3 бóльшая доля перенесших COVID-19 среди работающей части населения в сравнении с лицами без регулярной занятости, также может быть объяснена с позиции регулярности и широты контактов между людьми. На высокую связь между регулярной трудовой занятостью и серопозитивностью к SARS-CoV-2 указывают и результаты анализа Krieger E, et al (2023), проведенного через год после пандемии в Архангельске: отношение шансов составило 2,0 с 95% доверительным интервалом: 1,5; 2,8 [13]. Однако по нашим данным, частота тяжелого течения COVID-19 у работающих людей, наоборот, меньше: они реже попадали в стационар, чем неработающие (пенсионеры, инвалиды, безработные).…”

Section: Discussionunclassified

“…12 , Tantsyreva I. V. 12 , Baryshnikova I. N. 12 , Ataev M. G. 13 , Radzhabov M. O. 13 , Isakhanova M. M. 13 , Umetov M. A. 14 , Elgarova L. V. 14 , Khakuasheva I.…”

Section: кардиоваскулярная терапия и профилактика 2023;22mentioning

confidence: 99%

“…Тверь; 12 ФГБОУ ВО "Южно-Уральский государственный медицинский университет" Минздрава России. Челябинск; 13 Научно-исследовательский институт экологической медицины им. С. А. Абусуева, ФГБОУ ВО "Дагестанский государственный медицинский университет" Минздрава России.…”

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Proportion of COVID-19 survivors in 2020-2022 in the Russian population (according to the ESSE-RF3 study)

Muromtseva,

Shalnova,

Kutsenko

et al. 2023

Cardiovasc Ther Prev

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Aim. To study the proportion of coronavirus disease 2019 (COVID-19) survivors and hospitalization cases of the Russian population for the period 2020-2022, depending on socio-demographic characteristics.Material and methods. The work was performed on random samples of the population aged 35-74 years from 15 regions participating in the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation-3 (ESSE-RF3) study. The examination was carried out from February 2020 to March-April 2022 (n=28718, 47% men).Results. According to a survey of sample participants, the proportion of respondents who had COVID-19 by the spring of 2022 among all surveyed was 26,0%. Among 45-54-year-old respondents, this parameter was maximum (28,0%), while among those aged 65-74-year-old — minimal (22,3%). The following categories of people were more likely to have COVID-19: women (27,9 vs 23,9% of men, p<0,001), persons with higher education (30 vs 22,6% persons without higher education, p<0,001), persons with high income (30,0 vs 24,3% low-income, p=0,002), persons with family (26,6 vs 24,8% single, p<0,001), employed persons (28,4 vs 21,7% non-employed, p<0,001), as well as those living in urban areas (26,5 vs 24,5% country people, p=0,003). But those less likely to have COVID-19 (men, people without higher education, low-income, single, unemployed or rural residents) had more severe disease course. The following categories of people had higher hospitalization rates: men (26,0 vs 20,9% women, p<0,001), patients without higher education (27,1 vs 19,6% those with higher education, p<0,001), non-employed (34,3 vs 18,4% workers), p<0,001) and rural residents (27,2 vs 22,0% of city residents, p<0,001). Hospitalization rate was not associated with the level of income and marital status. However, low-income and single people were more likely to require mechanical ventilation.Conclusion. The results obtained by survey reflect the following population data: the proportion of patients after COVID-19, hospitalization rate and the development of severe acute respiratory failure requiring mechanical ventilation among Russians for the period 2020-2022. This can complement the population data demonstrated by state statistics. Special attention from the healthcare system, both during treatment and prevention of COVID-19, requires males, people aged ≥65 years, low-income people, single people (widowers, divorced), unemployed people (pensioners, disabled people, nonemployed), rural residents and people without higher education.

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Section: Discussionunclassified

“…12 , Tantsyreva I. V. 12 , Baryshnikova I. N. 12 , Ataev M. G. 13 , Radzhabov M. O. 13 , Isakhanova M. M. 13 , Umetov M. A. 14 , Elgarova L. V. 14 , Khakuasheva I.…”

Section: кардиоваскулярная терапия и профилактика 2023;22mentioning

confidence: 99%

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Proportion of COVID-19 survivors in 2020-2022 in the Russian population (according to the ESSE-RF3 study)

Muromtseva,

Shalnova,

Kutsenko

et al. 2023

Cardiovasc Ther Prev

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“…The duration of natural immunity from COVID-19 and its effectivity against new strains are the subject of many investigations for the moment as well as the effectiveness of the vaccination. One way to assess the level of population immunity is to estimate the seroprevalence of anti-SARS-CoV-2 IgG antibodies [4,5]. The following step is to incorporate such information in the model and to simulate the circulation of existing and new strains of SARS-Cov2.…”

Section: Discussionmentioning

confidence: 99%

918 BGRS/SB-2022 Seeking the threshold for herd immunity in the synthetic population of a medium-sized city

2022

The Thirteenth International Multiconference

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“…Since then, several variants of the SARS-CoV-2 virus, such as Delta and Omicron, have been isolated from COVID-19 patients in Russia [ 29 ]. While there are limited data available on the antibody response to SARS-CoV-2 [ 30 ], even less is known about the production of neutralizing antibodies in COVID-19 patients in Russia [ 31 ]. To address this knowledge gap, our study aimed to analyze the humoral immune response in mild, moderate, and severe COVID-19 patients from the Republic of Tatarstan, Russia, with a specific focus on studying neutralizing antibodies.…”

Section: Introductionmentioning

confidence: 99%

Neutralizing Antibodies in COVID-19 Serum from Tatarstan, Russia

Hamza

Martynova

Garanina

et al. 2023

IJMS

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The severity of COVID-19 is a result of the complex interplay between various branches of the immune system. However, our understanding of the role of neutralizing antibodies and the activation of cellular immune response in COVID-19 pathogenesis remains limited. In this study, we investigated neutralizing antibodies in patients with mild, moderate, and severe COVID-19, analyzing their cross-reactivity with the Wuhan and Omicron variants. We also assessed the activation of the immune response by measuring serum cytokines in patients with mild, moderate, and severe COVID-19. Our findings suggest the early activation of neutralizing antibodies in moderate COVID-19 compared to mild cases. We also observed a strong correlation between the cross-reactivity of neutralizing antibodies to the Omicron and Wuhan variants and the severity of the disease. In addition, we found that Th1 lymphocyte activation was present in mild and moderate cases, while inflammasomes and Th17 lymphocytes were activated in severe COVID-19. In conclusion, our data indicate that the early activation of neutralizing antibodies is evident in moderate COVID-19, and there is a strong correlation between the cross-reactivity of neutralizing antibodies and the severity of the disease. Our findings suggest that the Th1 immune response may play a protective role, while inflammasome and Th17 activation may be involved in severe COVID-19.

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Seroprevalence of SARS-Cov-2 Antibodies in Adults, Arkhangelsk, Russia

Cited by 6 publications

References 9 publications

Proportion of COVID-19 survivors in 2020-2022 in the Russian population (according to the ESSE-RF3 study)

Proportion of COVID-19 survivors in 2020-2022 in the Russian population (according to the ESSE-RF3 study)

918 BGRS/SB-2022 Seeking the threshold for herd immunity in the synthetic population of a medium-sized city

Neutralizing Antibodies in COVID-19 Serum from Tatarstan, Russia

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