Seroprevalence of SARS-CoV-2 (COVID-19) among healthcare workers in Saudi Arabia: comparing case and control hospitals

Alserehi, Haleema; Alqunaibet, Ada; Al‐Tawfiq, Jaffar A.; Alharbi, Naif Khalaf; Alshukairi, Abeer N.; Alanazi, Khalid H.; Saleh, Ghada Mohammed Bin; Alshehri, A. M.; Almasoud, Abdulrahman; Hashem, Anwar M.; Alruwaily, Amaal; Alaswad, Rehab; Almutlaq, Hind; Almudaiheem, Abdulllah Ali; Othman, Fatmah; Aldakeel, Sumayh A.; Ghararah, Mouath Rashid Abu; Jokhdar, Hani; Algwizani, Abdullah; Almudarra, Sami; Albarrag, Ahmed

doi:10.1016/j.diagmicrobio.2020.115273

Cited by 70 publications

(87 citation statements)

References 23 publications

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“…Other studies have described varied results depending on the inclusion or exclusion of confirmed COVID-19 cases in the analysis ( Gómez-Ochoa et al, 2020 ). The low SARS-CoV-2 antibodies seroprevalence in our study was comparable to the national multi-center study showing 2.36% seropositivity and it is suggestive of effective infection control measures among HCW ( Alserehi et al, 2020 ). Knowing these results, a significant number of HCWs will be at risk of COVID-19 infection.…”

Section: Discussionsupporting

confidence: 85%

“…At this stage and through the post-pandemic phase, it is important to assess the virus circulation and evaluate the seroprevalence of neutralizing antibody among the community ( Peto, 2020 , Sunjaya and Sunjaya, 2020 ). Few reports addressed the seroprevalence status among the Saudi population ( Alandijany et al, 2021 , Alserehi et al, 2020 ). In this study, we have evaluated the seroprevalence rate among HCWs at the SFH, one of the COVID-19 referral centers in Makkah, Saudi Arabia.…”

Section: Discussionmentioning

confidence: 99%

“…A recent national multi-center study in Saudi Arabia showed 2.36% seroprevalence of SARS-CoV-2 antibodies among HCWs. However, there was discordant results between the commercial electro-chemiluminescence immunoassay (ECLIA) and the pseudotyped viral particles neutralization assay ( Alserehi et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of neutralizing antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among healthcare workers in Makkah, Saudi Arabia

Ahmed

Dada

Alshukairi

et al. 2021

Journal of King Saud University - Science

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Objective The new coronavirus disease 2019 (COVID-19) is a major health problem worldwide. The surveillance of seropositive individuals serves as an indicator to the extent of infection spread and provides an estimation of herd immunity status among population. Reports from different countries investigated this issue among healthcare workers (HCWs) who are “at risk” and “sources of risk” for COVID-19. This study aims to investigate the seroprevalence of COVID-19 among HCWs in one of the COVID-19 referral centers in Makkah, Saudi Arabia using three different serological methods. Methods In-house developed enzyme-linked immunoassay (ELISA), commercially available electro-chemiluminescence immunoassay (ECLIA), and microneutralization (MN) assay were utilized to determine the seroprevalence rate among the study population. 204 HCWs participated in the study. Both physicians and nurses working in the COVID-19 and non COVID-19 areas were included. Twelve out of 204 were confirmed cases of COVID-19 with variable disease severity. Samples from recovered HCWs were collected four weeks post diagnosis. Results The overall seroprevalence rate was 6.3% (13 out of 204) using the in-house ELISA and MN assay and it was 5.8% (12 out of 204) using the commercial ECLIA. Among HCWs undiagnosed with COVID-19, the seroprevalence was 2% (4 out 192). Notably, neutralizing antibodies were not detected in 3 (25%) out 12 confirmed cases of COVID-19. Conclusions Our study, similar to the recent national multi-center study, showed a low seroprevalence of SARS-Cov-2 antibodies among HCWs. Concordance of results between the commercial electro-chemiluminescence immunoassay (ECLIA), in-house ELISA and MN assay was observed. The in-house ELISA is a promising tool for the serological diagnosis of SARS-CoV-2 infection. However, seroprevalence studies may underestimate the extent of COVID-19 infection as some cases with mild disease did not have detectable antibody responses.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

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Seroprevalence of neutralizing antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among healthcare workers in Makkah, Saudi Arabia

Ahmed

Dada

Alshukairi

et al. 2021

Journal of King Saud University - Science

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“…In this study, Makkah’s directorate of health affairs, the health authority for the city of Makkah and its surrounding areas, had the highest proportion of seropositivity with 8.1% prevalence compared to the other participating directorates. The city of Makkah itself was also highly affected and under complete lockdown and had curfew for a longer time than the other cities in the country ( Algaissi et al, 2020 , Alserehi et al, 2020 , Obeid et al, 2020 ). In addition, Madinah had 14.6% of the cases and had 4.1% positivity rate.…”

Section: Discussionmentioning

confidence: 99%

“…The participants were included in the study from 20 to 25 May 2020. The current study was conducted at the time when the Kingdom of Saudi Arabia had 62,000-80,000 cases and just before the peak of cases in the country ( Alserehi et al, 2020 ). All participants signed informed consents, and completed the study questionnaire.…”

Section: Methodsmentioning

confidence: 99%

Seroprevalence of antibodies to SARS-CoV-2 among blood donors in the early months of the pandemic in Saudi Arabia

Banjar¹,

Al‐Tawfiq²,

Alruwaily³

et al. 2021

International Journal of Infectious Diseases

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Background: Serologic testing provides better understanding of SARS-CoV-2 prevalence and its transmission. This study was an investigation of the prevalence of antibodies to SARS-CoV-2 among blood donors in Saudi Arabia. Objective: To estimate the seroprevalence of anti-SARS-CoV-2 antibodies among blood donors in Saudi Arabia during the early phase of the COVID-19 pandemic. Methods: Serology results and epidemiological data were analyzed for 837 adult blood donors, with no confirmed SARS-CoV-2 infection, in Saudi Arabia from 20th to 25th May 2020. Seroprevalence was determined using electrochemical immunoassay to detect anti-SARS-CoV-2 antibodies. Results: The overall seroprevalence of anti-SARS-CoV-2 antibodies was 1.4% (12/837). Non-citizens had higher seroprevalence compared with citizens (OR 13.6, p = 0.001). Secondary education was significantly associated with higher seroprevalence compared with higher education (OR 6.8, p = 0.005). The data showed that the highest seroprevalence was in Makkah (8.1%). Uisng Makkah seroprevalence as the reference, the seroprevalence in other areas was: Madinah 4.1% (OR 0.48, 95% CI 0.12À1.94), Jeddah 2.3% (OR 0.27, 95% CI 0.31À2.25), and Qassim 2.9 % (OR 0.34, 95% CI 0.04À2.89) and these were not statistically different from seroprevalence in the Makkah region. Conclusions: At the early months of the COVID-19 pandemic in Saudi Arabia, the seroprevalence of antibodies to SARS-CoV-2 among blood donors was low, but was higher among non-citizens. These findings may indicate that non-citizens and less educated individuals may be less attentive to preventive measures. Monitoring seroprevalence trends over time require repeated sampling.

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Covid-19 Diagnosis, Prognosis, and Rehabilitation: Latest Perceptions, Challenges, and Future Directions

Priya,

Sujithra,

Kanakaraj

2023

EAI/Springer Innovations in Communication and Computing

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Seroprevalence of SARS-CoV-2 (COVID-19) among healthcare workers in Saudi Arabia: comparing case and control hospitals

Cited by 70 publications

References 23 publications

Seroprevalence of neutralizing antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among healthcare workers in Makkah, Saudi Arabia

Seroprevalence of neutralizing antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among healthcare workers in Makkah, Saudi Arabia

Seroprevalence of antibodies to SARS-CoV-2 among blood donors in the early months of the pandemic in Saudi Arabia

Covid-19 Diagnosis, Prognosis, and Rehabilitation: Latest Perceptions, Challenges, and Future Directions

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