Seroprevalence of Scrub Typhus Infection in Arunachal Pradesh, India

Jakharia, Aniruddha; Borkakoty, Biswajyoti; Biswas, Dipankar; Yadav, Kaushal; Mahanta, Jagadish

doi:10.1089/vbz.2016.1970

Cited by 23 publications

(16 citation statements)

References 9 publications

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“…7,14 According to World health organisation "Scrub typhus is probably one of the most underdiagnosed and under reported febrile illness requiring hospitalization. In our study seropositivity of Scrub typhus was 20% which was higher than Rao et al 15 23 and Jhakaria et al 24 In our study Male affected more than female (60% vs 40%) Similar distribution was seen in Madhusmita et al 19 (61.7%), Palas Das et al 25 (58%), Raghunath et al 25 (61%) Lalrinkima et al 1 (56.6%) but female more than male distribution was seen in Saramma et al 21 (65% female), Rajendra et al 26 (64% female)). It may be due to fact that in this part of Odisha male are more involved in agricultural works than female.…”

Section: Discussioncontrasting

confidence: 57%

Seropositivity of Scrub Typhus Inpatients Attending a Tertiary Care Hospital in Western Odisha

Mukherjee¹,

Dash²,

Tiwari³

2020

jemds

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BACKGROUND Scrub typhus is a vector borne Rickettsial disease caused by Orientia tsutsugamushi and has been reported from tsutsugamushi triangle which includes India. It is a reemerging pathogen in India including the state of Odisha. This study was conducted to determine seropositivity of scrub typhus in patients attending a tertiary care hospital of Western Odisha. METHODS Fifty febrile patients who were negative for Malaria, Dengue and Leptospira attending a tertiary care hospital of Western Odisha were enrolled in the study. 3 ml of blood was collected, and serum was separated. IgM SD Bioline Tsutsugamushi lateral flow immunochromatography test was performed as per manufacturer instruction. Positive samples were confirmed by PCR method (Geno-Sen's ST Real Time PCR). RESULTS 20% of patients were positive for IgM SD Bioline Tsutsugamushi card test. 60% of positive patients were male. 20% of positive patients were having pathognomonic eschar. 60 % of infected patients were in the age group of 10-30. CONCLUSIONS In this study, 20% of febrile patients were positive for Scrub typhus infection. So, it should be included in the differential diagnosis of a febrile patient in Western Odisha.

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Section: Discussioncontrasting

confidence: 57%

Seropositivity of Scrub Typhus Inpatients Attending a Tertiary Care Hospital in Western Odisha

Mukherjee¹,

Dash²,

Tiwari³

2020

jemds

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“…The reported seroprevalence of O . tsutsugamushi for each country is shown in Table 1 [ 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 ]. The reports of outbreaks of scrub typhus are summarized in Table 2 [ 43 , 94 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , …”

Section: Methodsmentioning

confidence: 99%

A review of the global epidemiology of scrub typhus

et al. 2017

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Scrub typhus is a serious public health problem in the Asia-Pacific area. It threatens one billion people globally, and causes illness in one million people each year. Caused by Orientia tsutsugamushi, scrub typhus can result in severe multiorgan failure with a case fatality rate up to 70% without appropriate treatment. The antigenic heterogeneity of O. tsutsugamushi precludes generic immunity and allows reinfection. As a neglected disease, there is still a large gap in our knowledge of the disease, as evidenced by the sporadic epidemiologic data and other related public health information regarding scrub typhus in its endemic areas. Our objective is to provide a systematic analysis of current epidemiology, prevention and control of scrub typhus in its long-standing endemic areas and recently recognized foci of infection.

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“…6 Studies in southern part of India report a seroprevalence of 15 to 40% in general population. 7,8 In a multi-centric study of etiology of acute undifferentiated fever in India, 16% was diagnosed as dengue, 35% as salmonella infections and 10% as scrub typhus. Among the other illnesses were malaria 17%, bacteraemia 8%, leptospirosis 7%, and chikungunya 6%.…”

Section: Introductionmentioning

confidence: 99%

Differentiating Scrub Typhus, Dengue Fever and Typhoid Fever in Indian Children Presenting with Acute Febrile Illness

Chatterjee

Mondal

Kaushik

et al. 2020

J. Nepal Paedtr. Soc.

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Introduction: The disease spectrum of dengue, scrub typhus and typhoid presenting as acute febrile illness is often a diagnostic dilemma to the clinician. The purpose of this study is to compare the clinical features and laboratory parameters of children suffering from typhoid, dengue and scrub typhus and use these parameters in early identification of scrub typhus before conclusion is made from serological diagnosis. Methods: A retrospective observational analytical study was conducted among children presenting with acute febrile illness in a tertiary care level hospital. Over the period of one year 113 cases were identified of which 39 were dengue, 44 were typhoid and 30 were scrub typhus. Results: The mean age of the children was 7.45 ± 2.98 years, median was eight with an interquartile range of six to ten years. The male to female ratio was 1.3:1. Symptoms of vomiting (61.54%), headache (46.15%) and hepatomegaly (47.37%) were significantly higher among children with dengue fever. A significantly higher number of children with scrub typhus fever had temperature above 40°C. The incidence of low haemoglobin, raised C reactive protein, raised ALT and low albumin levels were significantly higher in them. Children with acute febrile illness having temperature > 40°C, absolute neutrophil/lymphocyte ratio > 2 early in the illness were more likely to suffer from scrub typhus with relative probability ratio (RPR) of 25.68 and 10.57 respectively (p < 0.001). Children with WBC < 5000/mm3 were more likely to be suffering from dengue with RPR of 10.60 (p < 0.001). Conclusion: Children with acute febrile illness with temperature > 40°C and absolute neutrophil/lymphocyte ratio > 2 early in the illness were more likely to be suffering from scrub typhus.

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Seroprevalence of Scrub Typhus Infection in Arunachal Pradesh, India

Cited by 23 publications

References 9 publications

Seropositivity of Scrub Typhus Inpatients Attending a Tertiary Care Hospital in Western Odisha

Seropositivity of Scrub Typhus Inpatients Attending a Tertiary Care Hospital in Western Odisha

A review of the global epidemiology of scrub typhus

Differentiating Scrub Typhus, Dengue Fever and Typhoid Fever in Indian Children Presenting with Acute Febrile Illness

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