2013
DOI: 10.1186/1471-2369-14-101
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Seroprevalence of Streptococcal Inhibitor of Complement (SIC) suggests association of streptococcal infection with chronic kidney disease

Abstract: BackgroundGroup A streptococcus (GAS) is an etiological agent for the immune mediated sequela post streptococcal glomerulonephritis (PSGN). In some populations PSGN is recognized as a risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). It was found that a significantly greater proportion of subjects with past history of PSGN than without the history exhibited seroreactions to streptococcal antigens called streptococcal inhibitor of complement (SIC) and to distantly related SIC (DRS… Show more

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Cited by 7 publications
(15 citation statements)
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“…A similar study showed an association between APSGN and SIC seropositivity in a Swedish pediatric population (432). More recently, such serological observations were extended to chronic kidney disease and end-stage renal disease patients in India (Mumbai), where both GAS diseases and chronic renal disease are endemic (433). Interestingly, in this population, SIC seropositivity was associated with chronic kidney disease and endstage renal disease.…”
Section: Kidneysmentioning
confidence: 68%
“…A similar study showed an association between APSGN and SIC seropositivity in a Swedish pediatric population (432). More recently, such serological observations were extended to chronic kidney disease and end-stage renal disease patients in India (Mumbai), where both GAS diseases and chronic renal disease are endemic (433). Interestingly, in this population, SIC seropositivity was associated with chronic kidney disease and endstage renal disease.…”
Section: Kidneysmentioning
confidence: 68%
“…Independent agematched healthy control sera were also collected for the PSGN (n ϭ 25) and combined CKD/ESRD (n ϭ 70) groups. These study subjects were the same as those described in our previous reports (9,13). Sera were stored at Ϫ80°C until use.…”
Section: Methodsmentioning
confidence: 99%
“…Medical College and KEM Hospital (reference EC/GOVT-4/2010). Where appropriate, as part of our previous studies (13), patients had already been assessed for renal impairment (abnormal persistent serum creatinine levels, uremic syndromes, protein urea, urine protein/creatinine ratio, and estimated glomerular filtration rates) and for anti-streptolycin O titers.…”
Section: Methodsmentioning
confidence: 99%
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