Seroprevalence of Syphilis in Apparently Healthy Students from a Tertiary Institution in Benin City, Nigeria

Ophori, E. A.; Atanunu, Ovie; Johnny, Ejiro Jessica; Adu, Mathew

doi:10.7883/yoken.63.437

Cited by 9 publications

(4 citation statements)

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“…This study also revealed a higher prevalence in males than females even though equal numbers of males and females were sampled. This is in consonance with other studies which have documented higher prevalence in males [16] reported higher prevalence of 6.5% in males as against 2.9% in females though this finding attributed this to the difference in sample size between males and females [25] reported a prevalence of 18.6 and 11.4% in males and female college students in Benin City Nigeria while [26] also reported a higher prevalence in male than in female college students in China. Higher prevalence in males has been associated with several factors chief among which is males sleeping with males (MSM) [24,26]…”

Section: Discussionsupporting

confidence: 88%

Prevalence of Treponema pallidium amongst Students of Delta State University, South-South Nigeria

Oghenemaro,

Chinedu,

Akpevwe

2023

IJTDH

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Objective: Infection due to Treponema pallidum (syphilis) is a major challenge and continues to be a public health problem around the world. It is a bacterial infection transmitted commonly through sexual contact, blood and also through mother-to-child (vertical). A cross-sectional study to investigate the prevalence of syphilis among students of Delta State University, Abraka was carried out between September 2022 and January 2023. Method: Data and blood samples were collected randomly from 500 participants from the various faculties of the University. Blood samples were collected in EDTA bottles following aseptic techniques and subsequently screened for syphilis using the rapid test (RT) method. Results: Of the 500 samples screened, 143 were positive for T. pallidium giving an overall prevalence of 48.6%. Students from the faculty of science recorded the highest prevalence of 68%, this was followed by students from the faculty of Arts (33%) while students from the faculty of Basic Medical Sciences recorded the least prevalence of 15%. This difference in prevalence among the faculties was statistically insignificant (P=0.695). Overall, a higher prevalence (40.4%) was recorded for males than females (16.8%) (P=1.24). The highest prevalence of 42% was recorded among males from the faculty of science while the lowest was recorded among females from the faculty of Education. The difference in prevalence among genders in the various faculties when compared was not statistically significant (P=0.201). Conclusion: This study has revealed a relatively high level of infection with syphilis (T. palladium) among students of Delta State University Abraka and should be a concern. There is therefore a dire need for proper enlightenment on this disease and behavioural change among this vulnerable population.

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Section: Discussionsupporting

confidence: 88%

Prevalence of Treponema pallidium amongst Students of Delta State University, South-South Nigeria

Oghenemaro,

Chinedu,

Akpevwe

2023

IJTDH

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“…Among blood donors in Benin the prevalence of infection was 8.0% (Adegoke et al, 2010), 2.93% in 2008and 1.9% in 2009(Salawu et al, 2010. Interestingly, some researchers reported 15% among apparently healthy university students (Ophori et al, 2010) and 4.6% in a paramilitary agency (Nwokedi et al, 2005). Higher prevalence of syphilis have also been reported among different groups in other countries.…”

Section: Discussionmentioning

confidence: 99%

“…Syphilis is a systemic disease caused by the spirochete Treponema pallidum. This disease has been reported as one of the common sexually transmitted infections (STIs) in Nigeria (Obiajuru and Jude, 2007).The route of transmission is almost always sexual contact although there may be vertical transmission, transmission via blood products and via intravenous drug use (Ophori et al, 2010;Tessema et al, 2010;Adegoke et al, 2011). Reports in late 2001 by World Health Organisation (WHO) showed that 12 million people become infected with syphilis each year (Campos et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Epidemiological studies have reported that STIs including syphilis are associated with an increased risk for HIV transmission among both homo and heterosexual people (Wesserhelt, 1992;Mahajan et al, 2008;Adegoke et al, 2011). A dual infection of HIV and Treponema pallidum apart from increasing morbidity and mortality (Ophori et al, 2010) is known to result in some medical complications like an alteration in the natural history of syphilis, dosage and duration of required treatment for the cure of syphilis (Nnoruka and Ezeoke, 2005;Uneke et al, 2006;Turbadar et al, 2007). Similarly, it can lead to male and female infertility and in pregnant women it may result in still birth, prenatal death and serious neonatal infection (Schmid, 2004).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of Treponema pallidum Infection among Human Immunodeficiency Virus Seropositive Persons and Their Corresponding CD4 Counts in a Nigerian Cohort

Pennap¹,

Osita²,

Adoga³

et al. 2011

BMRJ

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Background: Sexually transmitted infections are a major public health problem especially with the advent of HIV/AIDS. This study was conducted to determine the prevalence of Syphilis among HIV seropositive persons. The study population was seropositive persons accessing antiretroviral therapy (ART) at the Federal Medical Center Keffi. Methodology: Venous blood (5ml) was collected from each of the 200 consenting participants between February and August 2010. Their syphilis serostatus was determined using Rapid Plasma Reagin test and confirmed by an immunochromatographic rapid syphilis test kit. The CD4 count of the positive sample was also determined. Results: Of the 200 persons screened, 56 were males and 144 were females. The prevalence of Treponema pallidum in this study population was 0.5% (1/200). The HIVsyphilis positive was a married man aged 35 years and with a CD4 cell count of ≥ 200 cells/uL. Conclusion: This study reported a very low prevalence of syphilis among HIV positive persons. It is recommended that the sexual partner(s) of the study index case should be traced and also treated to prevent reinfection and/or continued spread of the infection. Despite the low prevalence in this study, syphilis screening among those with HIV should be advocated routinely to avoid the complications associated with the dual infection.

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Mathematical Assessment of the Role of Early Latent Infections and Targeted Control Strategies on Syphilis Transmission Dynamics

et al. 2018

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A new multi-stage deterministic model for the transmission dynamics of syphilis, which incorporates disease transmission by individuals in the early latent stage of syphilis infection and the reversions of early latent syphilis to the primary and secondary stages, is formulated and rigorously analysed. The model is used to assess the population-level impact of preventive (condom use) and therapeutic measures (treatment using antibiotics) against the spread of the disease in a community. It is shown that the disease-free equilibrium of the model is globally-asymptotically stable whenever the associated control reproduction number (denoted by [Formula: see text]) is less than unity. A special case of the model is shown to have a unique and globally-asymptotically stable endemic equilibrium whenever the associated reproduction number (denoted by [Formula: see text]) exceeds unity. Uncertainty and sensitivity analysis of the model, using parameter values and ranges relevant to syphilis transmission dynamics in Nigeria, show that the top three parameters that drive the syphilis infection (with respect to [Formula: see text]) are the disease transmission rate ([Formula: see text]), compliance in condom use (c) and efficacy of condom ([Formula: see text]). Numerical simulations of the model show that the targeted treatment of secondary syphilis cases is more effective than the targeted treatment of individuals in the primary or early latent stage of syphilis infection.

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Seroprevalence of Syphilis in Apparently Healthy Students from a Tertiary Institution in Benin City, Nigeria

Cited by 9 publications

References 8 publications

Prevalence of Treponema pallidium amongst Students of Delta State University, South-South Nigeria

Prevalence of Treponema pallidium amongst Students of Delta State University, South-South Nigeria

Prevalence of Treponema pallidum Infection among Human Immunodeficiency Virus Seropositive Persons and Their Corresponding CD4 Counts in a Nigerian Cohort

Mathematical Assessment of the Role of Early Latent Infections and Targeted Control Strategies on Syphilis Transmission Dynamics

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