Seroprevalence of TORCH infection among pregnant women

Abstract

Background: TORCH infection complex during pregnancy has bad obstetric outcomes starting from low birth weight to congenital anomalies, sensory neural deafness, mental retardation, cerebral palsy and sometimes to fatal outcomes like abortion and still birth. As these diseases remain mostly asymptomatic these are rarely tested during pregnancy. Serology is the mainstay of diagnosing these infections..Methods: A cross sectional study was undertaken to estimate the burden of these infections in a rural belt of western Odisha where majority of the population depend upon agricultural work. A total number of 402 antenatal cases were screened by ELISA test for presence of IgG&IgM antibodies against toxoplasma, rubella virus, cytomegalovirus (CMV), herpes simplex virus (HSV) 1 & 2; RPR test was done to know seroprevalence of Syphilis.Results: It was found that Rubella is the most predominant infection being positive in 69.1% of the cases (IgG 68.4%, IgM 0.5%, and both IgG&IgM 0.25%), followed by CMV infection-66.7% (IgG 57.2%, IgM 1.7%, both 7.7%), Toxoplasma infection-39.8% (IgG 38.3%, IgM 0.7%, both 0.7%), HSV 1-23.6% (IgG 21.1%, IgM 2%, both 0.25%) and HSV 2 – 13.2% (IgG 11.7%, IgM 1.6%, both 0.25%). The seoprevalence of syphilis by RPR was least common with 0.5%.Conclusions: This study showed that most of the infections have occurred by 20 years of age and before or during the 1st pregnancy. It is less common among the antenatal cases who have better education and have spouses servicing in private or government sectors signifying the more health and sanitation awareness among this group.

Seroprevalence of Toxoplasma Gondii, Rubella and Cytomegalovirus Among Pregnant Women in Our Clinic

“…Anti-Rubella IgM was found as 1% (63/6306) in the evaluation of Rubella seroprevalence in our study. Anti-Rubella IgM seroprevalence positivity ranges between 0.2% and 2.25% as seen in 13). When Cetinkaya et al evaluated the data of 90988 patients in 26 studies conducted in our country, this rate was reported as 0.78% (17).…”

Seroprevalence of Toxoplasma gondii, Rubella, Cytomegalovirus Detected by Enzyme Linked Fluorescent Assay Method in Pregnant Women Who Applied to Meram Medical Faculty Hospital in Konya Province

“…Dünyada yapılmış olan çeşitli çalışmalarda ise anti-T. gondii IgM pozitifliği %0.3-%13.3 aralığında anti-T.gondii IgG pozitifliği %1.71-%38.3 aralığında saptanmış olup bizim çalışmamıza benzer veriler elde edilmiştir. Anti-rubella IgM pozitifliği ise %0.5-%3 aralığında, anti-rubella IgG pozitifliği %68.4-%81.97 aralığında saptanmış olup; anti-CMV IgM pozitifliği %0.52-%1.8 aralığında, anti-CMV IgG pozitifliği ise %57.2-%95.09 aralığında saptanmış olup bizim çalışmamıza benzer veriler elde edilmiştir (36)(37)(38) .…”

Current Status of Immunoglobulin M and Immunoglobulin G Seroprevalence of Torch Infections in Pregnant Women With Bad Obstetric History at a Tertiary Care Hospital

“…The prevalence of TORCH infection varies geographically. 3,4,5,6 To the best of our knowledge, baseline data on seropositivity is not available from this part of Haryana.…”