Seroprevalence of ToRCH Pathogens among Children Admitted to a Tertiary Care Hospital in Eastern India for Cataract Surgery and Cochlear Transplantation

Abstract

The study aims to investigate the presence of TORCH infections in a child with bilateral cataracts and deafness and report the ToRCH serology screening profile (Toxoplasma gondii [TOX], rubella [RV], cytomegalovirus [CMV], and herpes simplex virus [HSV I/II]) in pediatric cataract and deafness. background TORCH serology is an indirect method for testing recent, old, or no infections. The TORCH serology screening profile of pediatric cataract and deafness cases in eastern India is still unknown. Methods Cases that had a clear clinical history of congenital cataracts and congenital deafness were included in the study. The study population consisted of 18 bilateral cataracts and 12 bilateral deafness child who was admitted to AIIMS Bhubaneswar for cataract surgery and cochlear implantation, respectively. Sera of all children were tested qualitatively and quantitatively for IgG/IgM antibodies against ToRCH agents in a sequential manner. objective To Know the immunity status against TORCH agents in children with bilateral cataracts and deafness. This gave us the chance to study the type of infection of children with 5 pathogens. Results Anti-IgG antibodies against the torch panel were detected in all cataract and deafness patients. Anti-CMV IgG was detected in 17 of 18 bilateral cataract children and 11 of 12 bilateral deaf children. The rates of anti-CMV IgG antibody positivity were significantly higher. In the cataract group, 94.44% and in the deafness group, 91.66% of the patient was Anti-CMV IgG positive. Besides this, 77.7 % of the patient from the cataract group and 75% from the deafness group was anti-RV IgG antibody positive. In bilateral cataract patients, IgG‑alone seropositive cases were mostly attributed to CMV (94.44%; 17/18), followed by RV (77.70%; 14/18), HSV‑I (27.70%; 5/18), TOX (27.70%; 5/18), and HSV‑II (16.60%; 3/18). In bilateral deafness patients, the spectrum of IgG alone seropositive cases was almost the same except for TOX (0/12). Conclusion The current study recommends interpreting ToRCH screening in pediatric cataracts and deafness with caution. Interpretation should include both serial qualitative and quantitative assays in tandem with clinical correlation to minimize diagnostic errors. The sero-clinical positivity needs to be tested in older children who might pose a threat to the spread of infection.