Seroprevalence of Toxoplasma gondii among a group of Egyptian patients with type I diabetes mellitus

Abstract

Background: Toxoplasmosis is probably one of the most common parasitic infections of humans. While infection of healthy adults is usually relatively mild, serious disease can result in utero or when the host is immunocompromised. Toxoplasmosis in diabetic patients may occur due to recently acquired acute infection or they may suffer from dissemination of reactivated latent infection. In the present study, the antinuclear antibody prevalence was tested to determine the possible relationship with Toxoplasma seroprevalence and clinical findings in type I diabetic patients. Methods: Toxoplasma gondii antibodies were tested serologically in 60 patients of type I diabetes mellitus and 60 controls using ELISA technique. Results: The seropositivity for anti-Toxoplasma IgG antibodies in the study groups was 45% in type I diabetes mellitus patients (group 1) and 23.3% in the control (group 2) with p value = 0.012 showing a statistically significant difference between groups, while only three patients of diabetes type1 group were positive for anti-Toxoplasma IgM with p value = 0.244 showing no statistically significant differences between the two groups. Results showed that only one patient of diabetes type 1 (group1) had positive ANA and one control (group2) had positive ANA. Thus, no correlation could be detected from such results. Conclusion: The study results showed a statistically significantly higher proportion (45%) of seropositivity anti-Toxoplasma IgG antibodies among type I diabetes mellitus patients compared to 23.3% among the control group, while there was no association could be detected between the studied groups regarding the ANA.

Seroepidemiology of Toxoplasma gondii in diabetic patients type 2 by enzyme-linked immunosorbent assay method in Zabol City, 2017–2018

“…(2019) reported other risk factors consisting of place of residence ( P < 0.001) and exposure to cats and soil ( P < 0.0001). [ 11 ] Accordingly, in the present study, we found a significant association between cat contact and the level of education in M2TD ( p -value<0.05) [ Figure 3 ].…”

Study on the effect of koumiss on reactivation of Toxoplasma gondii infection

“…When host immunity decreases in the state of T. gondii latent infection, latent infection is activated, causing severe acute toxoplasmosis again. In clinical studies, patients with solid malignant tumors, solid organ transplant (SOT) ( 26 ), human immunodeficiency virus (HIV)/AIDS, diabetes, and those receiving immunosuppressive agents have a high risk of reactivated toxoplasmosis ( 27 , 28 ). Therefore, reactivation of T. gondii infection is more common in patients with these diseases.…”

Association of Toxoplasma Gondii Infection With Diabetes Mellitus Using Nested-PCR and Sequencing

“…There have been several seromolecular studies between T. gondii and DM [21,22,25,27,[36][37][38]. We previously performed a case-control serological investigation using ELISA test regarding such association, suggesting that 16/98 T1DM, 55/95 T2DM patients, and 16/94 control subjects had previous exposure to Toxoplasma.…”

“…Besides, DM pathogenesis may be associated with infectious agents such as Helicobacter pylori [19] and Coxsackie B4 virus [20]. In this sense, T. gondii parasitic infection has been assumed to be involved in DM casualty, as demonstrated by seroprevalence data from Iraq, Egypt, Turkey, and Czech Republic [21][22][23][24][25][26][27]. In this case-control study, we shed light on the possible strain(s) of Toxoplasma isolated from diabetic patients referred to Imam Sajjad Hospital, Tehran, Iran, using nested-PCR and sequencing technologies.…”