Seroprevalence of Toxoplasma Gondii Infection and Its Associated Risk Factors in Neuropsychiatric Patients in Jazan Province, Saudi Arabia

Zaki, Wafaa M.; Hofdi, Rasha Y; Shebiley, Aisha A; Saadi, Z.; Ageel, Ali H

doi:10.21608/jesp.2016.78041

Cited by 7 publications

(5 citation statements)

References 21 publications

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“…Psychiatric patients who engaged in activities that involved contact with the soil had higher rates of T. gondii infection. These results are in line with those obtained by Achaw et al [ 54 ] in psychiatric patients from Gondar, Northern Ethiopia, Cong et al [ 58 ] in Eastern China, and Zaki et al [ 59 ] in Jazan Province, Saudi Arabia. Human infection has historically been associated with significant risk factors linked to exposure to soil [ 60 ].…”

Section: Discussionsupporting

confidence: 92%

Prevalence of Toxoplasma gondii IgG Antibodies and Associated Risk Factors in Psychiatric Patients from Western Romania: A Cross-Sectional Study

Grada,

Mihu,

Oatis

et al. 2024

Microorganisms

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Infection with the coccidian parasite Toxoplasma gondii was associated with an increased risk of several mental disorders. We conducted a case–control study of 464 consecutive psychiatric patients and assessed the prevalence of IgG antibodies against T. gondii and the potential risk factors associated with infection. T. gondii-specific antibodies were determined using a chemiluminescence assay. A questionnaire was utilized to assess the potential correlation between risk factors and Toxoplasma gondii seropositivity. IgG antibodies were found in 325 (70.04%) of the patients. We observed a higher likelihood of positive IgG antibodies against Toxoplasma gondii in older individuals, patients residing in rural areas, and females. We also noted associations between Toxoplasma gondii infection and certain risk factors, like activities that involve contact with soil, low-income levels, and limited educational attainment. Our findings indicate a high prevalence of T. gondii infection among psychiatric patients from Western Romania and provide new information regarding the potential risk factors associated with T. gondii in this population group. This study may serve as a foundation for future research and the development of preventive strategies.

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Section: Discussionsupporting

confidence: 92%

Prevalence of Toxoplasma gondii IgG Antibodies and Associated Risk Factors in Psychiatric Patients from Western Romania: A Cross-Sectional Study

Grada,

Mihu,

Oatis

et al. 2024

Microorganisms

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“…However, they described the limitations of the meta-analysis failing to fully represent the general population due to the samples being recruited through Facebook [ 143 ]. Other cross-section studies found no association between OCD and T. gondii infection [ 74 , 111 , 137 ]. Ultimately, the findings cumulatively suggest that there may be an association between OCD and chronic T. gondii infection in children, adolescents, and adults, but more studies must be done to confirm it.…”

Section: Methodology and Resultsmentioning

confidence: 94%

Neurological and Neurobehavioral Disorders Associated with Toxoplasma gondii Infection in Humans

Virus

Ehrhorn

Lui

et al. 2021

Journal of Parasitology Research

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The intracellular parasite Toxoplasma gondii is estimated to infect up to 30% of the world population, leading to lifelong chronic infection of the brain and muscle tissue. Although most latent T. gondii infections in humans have traditionally been considered asymptomatic, studies in rodents suggest phenotypic neurological changes are possible. Consequently, several studies have examined the link between T. gondii infection and diseases such as schizophrenia, epilepsy, depression, bipolar disorder, dysphoria, Alzheimer’s disease, Parkinson’s disease, and obsessive-compulsive disorder (OCD). To date, there is varying evidence of the relationship of T. gondii to these human neurological or neurobehavioral disorders. A thorough review of T. gondii literature was conducted to highlight and summarize current findings. We found that schizophrenia was most frequently linked to T. gondii infection, while sleep disruption showed no linkage to T. gondii infection, and other conditions having mixed support for a link to T. gondii. However, infection as a cause of human neurobehavioral disease has yet to be firmly established.

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“…A study in Egypt conducted on 120 healthy and 120 children with Down syndrome, hydrocephalus, microcephalus, attention deficit hyperactive disorder and epilepsy showed significantly higher seropositivity to Toxoplasma infection in these patients than the healthy subjects (38.3% vs. 20.0%) (El-Beshbishi, El-Tantawy et al 2018). In Zaki et al study on 162 neuropsychiatric patients and 162 healthy subjects, the seroprevalence of Toxoplasma infection among the case group was significantly higher than that of the control group (35.8% vs. 14.8%) (Zaki et al 2016).…”

Section: Discussionmentioning

confidence: 97%

“…study on 162 neuropsychiatric patients and 162 healthy subjects, the seroprevalence of Toxoplasma infection among the case group was significantly higher than that of the control group (35.8% vs. 14.8%) (Zaki et al . 2016).…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of toxoplasmosis among individuals with intellectual disability in Hormozgan Province, southern Iran

Omidian

Shahrbabak

Pouryousef

et al. 2023

J intellect Disabil Res

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Background People with mental defects are more likely to get the infection due to their low levels of health care and personal hygiene. The current study aimed to determine the seroprevalence of Toxoplasma infection among individuals with intellectual disabilities in Hormozgan province, southern Iran. Methods The study population was 117 individuals with intellectual disabilities. Venous blood (3 mL) was taken from each subject. A commercial ELISA kit was used to determine anti‐Toxoplasma IgG antibodies. Results Of 117 recruited subjects, 55 (47.0%) were men and 62 (53.0%) were women. The mean age of participants was 27.6 (±12.31) years. Out of 117 studied subjects, 76 had severe and 41 had profound intellectual disabilities. Anti‐Toxoplasma IgG antibodies were detected in the sera of 35 out of 117 (29.9%) individuals. Seropositivity to toxoplasmosis was significantly higher in severe than in individuals with profound intellectual disabilities (P < 0.05). There was no statistically significant association between Toxoplasma infection and age, sex and duration of residency in the rehabilitation centre. Conclusions The findings of this study indicate that the prevalence of Toxoplasma in people with intellectual disabilities is not much different from other groups of the community.

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Seroprevalence of Toxoplasma Gondii Infection and Its Associated Risk Factors in Neuropsychiatric Patients in Jazan Province, Saudi Arabia

Cited by 7 publications

References 21 publications

Prevalence of Toxoplasma gondii IgG Antibodies and Associated Risk Factors in Psychiatric Patients from Western Romania: A Cross-Sectional Study

Prevalence of Toxoplasma gondii IgG Antibodies and Associated Risk Factors in Psychiatric Patients from Western Romania: A Cross-Sectional Study

Neurological and Neurobehavioral Disorders Associated with Toxoplasma gondii Infection in Humans

Seroprevalence of toxoplasmosis among individuals with intellectual disability in Hormozgan Province, southern Iran

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