Seroprevalence of Transfusion Transmissible Infections among Blood Donors at a Tertiary Care Teaching Hospital in Central India

Varma, Amit; Malpani, Garima; Kosta, Susmit; Malukani, Kamal; Sarda, Bela; Raghuvanshi, Avinash

doi:10.21276/ijcmr.2019.6.12.34

Cited by 2 publications

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“…Our study results shows, overall cumulative frequency of TTIs in blood donors was 2.038%, and frequency of HBV, HCV, HIV-I/II, VDRL and MP were 1.111%, 0.431%, 0.201%, 0.29% and 0.006% respectively. Present study result shows a higher Prevalence of TTIs than Tehran, Iran (0.515%)[ 21 ] and studies from India; Gujarat (0.77%)[22], Telangana (0.96%) [ 23 ], Ranchi (1.59%)[ 24 ], Odisha (1.89%) [ 25 ], central India(1.43%)[ 26 ] and Ahmedabad (0.58%) [ 27 ]. Compared to present study higher prevalence of TTIs reported from western region of Saudi Arabia (7.93%), Equatorial New Guinea (18.7%), Mozambique (37.39%) and Burkina Faso (24%)[ 20 ], Peshawar, Pakistan (5.33%)[ 28 ], WR Saudi Arabia(7.93%)[ 20 ], NW, Ethiopia (5.43%)[ 29 ], Eastern Ethiopia (7.06%)[ 30 ] and Brazil (Brazil%)[ 31 ].…”

Section: Discussionmentioning

confidence: 56%

Prevalence of TTI among Indian blood donors

Thakur

2023

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Transfusion Transmissible Infections (TTIs) such as human immune-deficiency virus (HIV-I/II), hepatitis B virus (HBV), Hepatitis C virus (HCV), Malaria parasite (MP) and syphilis can spread through contaminated blood or blood products. The present study was designed to analyze the prevalence of TTIs and their association with blood group, among the blood donors of Delhi. Blood group was determined by hem-agglutination using Gel card. HIV, HBV, and HCV test was performed by ELISA, syphilis by RPR and MP rapid card method. A total of 345(2.038%) blood donors were positive for TTIs. Prevalence of HBV, HCV, HIV-I/II, syphilis and MP were 188(1.111%), 73(0.431%), 34(0.201%), 49(0.29%) and 1(0.006%) respectively. Our result shows a trend of decrease in prevalence of TTIs; 2.267%, 2.111% and 1.614% between the year 2020, 2021 and 2022 respectively. Significant association of syphilis infection (P=0.036) and HCV infection (P=0.012) with ABO blood group antigen was observed. Blood group O donors were 1.81 times more infected with syphilis compared to donor having A and B antigen. Donors having blood group antigen B were 1.80 times more infected with HCV compared to donor not having B antigen. HBV and HIV prevalence found to be not associated with ABO and Rh blood group antigens. A low prevalence of TTIs positivity was observed among blood donors. Public awareness, proper counseling, medical examination and testing can help to minimize TTIs. Our study results shows ABO blood group has an association with HCV and VDRL infection.

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Section: Discussionmentioning

confidence: 56%

Prevalence of TTI among Indian blood donors

Thakur

2023

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Prevalence of transfusion transmissible infections among various donor groups: A comparative analysis

Thakur,

Sinha,

Sharma

et al. 2025

World J Virol

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BACKGROUND Transfusion transmissible infections (TTIs) are illnesses spread through contaminated blood or blood products. In India, screening for TTIs such as hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV)-I/II, malaria, and syphilis is mandatory before blood transfusions. Worldwide, HCV, HBV, and HIV are the leading viruses causing mortality, affecting millions of people globally, including those with co-infections of HIV/HCV and HIV/HBV. Studies highlight the impact of TTIs on life expectancy and health risks, such as liver cirrhosis, cancer, and other diseases in individuals with chronic HBV. Globally, millions of blood donations take place annually, emphasizing the importance of maintaining blood safety. AIM To study the prevalence of TTIs, viz., HBV, HCV, HIV I/II, syphilis, and malaria parasite (MP), among different blood donor groups. METHODS The study assessed the prevalence of TTIs among different blood donor groups in Delhi, India. Groups included total donors, in-house donors, total camp donors, institutional camp donors, and community camp donors. Tests for HIV, HBV, and HCV were done using enzyme-linked immunosorbent assay, while syphilis was tested with rapid plasma reagins and MP rapid card methods. The prevalence of HBV, HCV, HIV, and syphilis, expressed as percentages. Differences in infection rates between the groups were analyzed using χ ² tests and P -values (less than 0.05). RESULTS The study evaluated TTIs among 42158 blood donors in Delhi. The overall cumulative frequency of TTIs in total blood donors was 2.071%, and the frequencies of HBV, HCV, HIV-I/II, venereal disease research laboratory, and MP were 1.048%, 0.425%, 0.221%, 0.377%, and 0.0024%, respectively. In-house donors, representing 37656 donors, had the highest transfusion transmissible infection (TTI) prevalence at 2.167%. Among total camp donors (4502 donors), TTIs were identified in 1.266% of donors, while community camp donors (2439 donors) exhibited a prevalence of 1.558%. Institutional camp donors (2063 donors) had the lowest TTI prevalence at 0.921%. Statistical analysis revealed significant differences in overall TTI prevalence, with total and in-house donors exhibiting higher rates compared to camp donors. CONCLUSION Ongoing monitoring and effective screening programs are essential for minimizing TTIs. Customizing blood safety measures for different donor groups and studying socio-economic-health factors is essential to improving blood safety.

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Seroprevalence of Transfusion Transmissible Infections among Blood Donors at a Tertiary Care Teaching Hospital in Central India

Cited by 2 publications

References 10 publications

Prevalence of TTI among Indian blood donors

Prevalence of TTI among Indian blood donors

Prevalence of transfusion transmissible infections among various donor groups: A comparative analysis

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