Seroprevalence of Trypanosoma cruzi infection among blood donors in the state of Bahia, Brazil

Miranda, Diego Lopes Paim; Ribeiro, Gilmar; Lanza, Fernanda Cardoso; Santos, Fred Luciano Neves; Reis, Renato Barbosa; Fraga, Deborah Bittencourt Mothé; Silva, Luciano Kalabric; Neto, Marinho Marques da Silva; Santana, Iraildes de Jesus; Reis, Mitermayer Galvão dos

doi:10.1590/0037-8682-0146-2019

Cited by 8 publications

(10 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results are consistent with other community-based seroprevalence studies [18,27,28]. People who had stopped studies after primary school were also at higher risk of having Chagas disease, in keeping with other studies of T. cruzi antibodies in blood donors in endemic countries [29]. This finding can be linked with the tendency for the disease to affect people with limited resources.…”

Section: Discussionsupporting

confidence: 91%

Community-based screening of Chagas disease among Latin American migrants in a non-endemic country: an observational study

et al. 2021

View full text Add to dashboard Cite

Background Chagas disease is a parasitic disease endemic to Latin America, but it has become a disease of global concern due to migration flows. Asymptomatic carriers may host the parasite for years, without knowing they are infected. The aim of this study is to assess prevalence of Chagas disease and evaluate the participants’ level of knowledge between Latin American migrants attending a community-based screening campaign. Methods Three community-based campaigns were performed in Alicante (Spain) in 2016, 2017 and 2018, including educational chats and blood tests for Trypanosoma cruzi serology. Participants completed a questionnaire assessing knowledge about the mechanisms of transmission, disease presentation, diagnosis, and treatment. People seropositive for T. cruzi underwent diagnostic confirmation by two different tests. Results were analyzed by multivariable logistic regression and expressed as adjusted odds ratios (aORs), adjusting for age, sex, and time in Spain. Results A total of 596 participants were included in the study; 17% were aged under 18 years. Prevalence in adults was 11% [54/496; 95% confidence interval (CI): 8.3–14.5%] versus 0% among children. All but one case were in Bolivians. Diagnosis was independently associated with having been born in Bolivia (aOR: 102, 95% CI: 13–781) and a primary school-level education (aOR: 2.40, 95% CI: 1.14–5.06). Of 54 people diagnosed with Chagas disease (most of whom were asymptomatic), 42 (77.7%) returned to the clinic at least once, and 24 (44.4%) received treatment. Multivariable analysis showed that coming from Argentina (aOR: 13, 95% CI: 1.61–1188) or Bolivia (aOR: 1.90, 95% CI: 1.19–3.39) and having received information about Chagas disease in Spain (aOR: 4.63, 95% CI: 2.54–8.97) were associated with a good level of knowledge on the disease. Having primary level studies (aOR: 0.59, 95% CI: 0.34–0.98) and coming from Ecuador (aOR: 4.63, 95% CI: 2.52–847) were independently associated with a lower level of knowledge. Conclusions Community-based interventions are a good strategy for diagnosing neglected diseases such as Chagas disease in non-endemic countries and for identifying and treating infected, asymptomatic individuals. Graphic abstract

show abstract

Section: Discussionsupporting

confidence: 91%

Community-based screening of Chagas disease among Latin American migrants in a non-endemic country: an observational study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…A summary of other studies in blood donors from different regions and years is presented in Table 2. Most of them show similar seroprevalences and sociodemographic characteristics to this study, except for the study performed by Remesar et al in the region known as Chaco, which is highly endemic [16][17][18][19][20][21][22][23][24].…”

Section: Discussionsupporting

confidence: 81%

Trends of Seroprevalence of Chagas´s diseases in healthy blood donors, solid organ donors and heart transplant recipients: experience of a single health care center in Colombia.

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Furthermore, it is possible that many CD‐affected donors could have been dismissed after the initial screening interview, which could explain the low proportion of positive samples (21/4993 or 0.42%), which is substantially below the reported CD prevalence of 3.5% in Salvador 32 . However, a recent study revealed a similar prevalence (0.62%) of CD among donors in Bahia deemed positive for T. cruzi infection following initial serological screening 33 …”

Section: Discussionmentioning

confidence: 97%

Assessment of Liaison XL Murex Chagas diagnostic performance in blood screening for Chagas disease using a reference array of chimeric antigens

et al. 2021

View full text Add to dashboard Cite

Background: Chagas disease (CD) serological screening at blood banks is usually performed by a single highly sensitive serological assay, with chemiluminescent immunoassays (CLIAs) being the method of choice. CLIAs employ recombinant, fusion peptides and/or chimeric antigens that selectively capture anti-Trypanosoma cruzi antibodies. However, despite high sensitivity, the ability of these tests to identify CD-positive cases should be evaluated against T. cruzi strains circulating in specific locales. Herein, we used a latent class analysis (LCA) approach employing an array of four chimeric antigens to assess the diagnostic performance of the Liaison XL Murex Chagas CLIA for the detection of anti-T. cruzi IgG in serum samples. Study Design and Methods:The study included a panel of 5014 serum samples collected from volunteer blood donors at the Hematology and Hemotherapy Foundation of the State of Bahia, submitted to anti-T. cruzi antibody detection using Liaison Chagas CLIA and LCA as a reference test in the absence of a gold standard.Results: LCA classified 4993 samples as negative, while positivity for T. cruzi antibodies was predicted in 21 samples. Compared with LCA, CLIA demonstrated sensitivity and specificity of 76.2% and 99.5%, respectively, providing an overall accuracy of 99.4%. Discussion: In blood banks lacking a de facto highly sensitive screening immunoassay, the low sensitivity offered by Liaison Chagas CLIA renders it unsuitable for standalone use in serological screening procedures for CD. Moreover, blood banks are encouraged to carefully assess the ability of diagnostic methods to identify local T. cruzi strains in circulation.

show abstract

Seroprevalence of Trypanosoma cruzi infection among blood donors in the state of Bahia, Brazil

Cited by 8 publications

References 20 publications

Community-based screening of Chagas disease among Latin American migrants in a non-endemic country: an observational study

Community-based screening of Chagas disease among Latin American migrants in a non-endemic country: an observational study

Trends of Seroprevalence of Chagas´s diseases in healthy blood donors, solid organ donors and heart transplant recipients: experience of a single health care center in Colombia.

Assessment of Liaison XL Murex Chagas diagnostic performance in blood screening for Chagas disease using a reference array of chimeric antigens

Contact Info

Product

Resources

About