Seroprevalence of varicella-zoster virus in the prevaccine era: A population-based study in Izmir, Turkey

Köse, Şükran; Mandıracıoğlu, Aliye; Senger, Süheyla Serin; Ulu, Yıldız; Çavdar, Gülsün; Göl, Başak; Gürbüz, İlhan; Sarıavcı, Şenol; Nohutçu, Neşe

doi:10.1016/j.jiph.2012.10.003

Cited by 12 publications

(17 citation statements)

References 22 publications

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“…In Pakistan, a tropical pattern of VZV epidemiology was found with a seroprevalence of 42.5% in the 11-15- year age group and 46.7% in the 16-20- year age group [ 27 ]. Our findings are consistent with two studies in Turkey; in one of them18.8% of adolescents and 11.7% of young adults were seronegative for VZV [ 28 ], and in the other one, 94.3% of individuals older than 15 were seropositive for VZV [ 29 ].…”

Section: Discussionsupporting

confidence: 92%

Seroprevalence and Risk Factors of Varicella Zoster Infection in Iranian Adolescents: A Multilevel Analysis; The CASPIAN-III Study

et al. 2016

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The objective of this study was to evaluate the varicella zoster virus (VZV) immunity in Iranian adolescents. It was conducted as a primary study for vaccine implementation, and to investigate the association of climatic and socioeconomic factors with the epidemiology of this infection. In this cross- sectional study, anti VZV antibodies were measured in serum samples obtained in a national school-based health survey (CASPIAN- III). Association of demographic, socio-economic, and climate of the living region with the frequency of VZV was investigated by multivariate multilevel analysis. Overall, sera of 2753 individuals aged 10–18 were tested for VZV antibodies, from those 87.4% were positive. The prevalence was statistically different in four socio-geographic regions (P<0.001), varying between 85.24% in West region (mostly mountainous areas with cold climate) to 94.59% in Southeast region (subtropical climate). Among variables studied, only age and mean daily temperature of the living area were positively associated with the VZV seroprevalence. Our findings show that most Iranians develop immunity to VZV before the age of 10, but a substantial proportion of them are yet susceptible to the infection. Therefore, it seems that the best strategy to reduce the burden of the disease is to vaccinate high- risk adults, i.e. those without a history of varicella infection. The regional temperature might be the only determinant of VZV epidemiology in Iran.

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Section: Discussionsupporting

confidence: 92%

Seroprevalence and Risk Factors of Varicella Zoster Infection in Iranian Adolescents: A Multilevel Analysis; The CASPIAN-III Study

et al. 2016

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“…Some studies have reported that living in urban areas, living in a large family (≥ 4 people) and children with more siblings are factors associated with higher varicella seroprevalence. Many studies have found no gender difference for varicella seroprevalence (2,3,16,17,(28)(29)(30). Consistent with the current study, varicella seroprevalence was not associated with household size, income, occupation and education in a population-based study in Izmir in 2009-2010 (16).…”

Section: Discussionsupporting

confidence: 88%

Seroprevalence and social determinants of varicella in Turkey

Hekimoğlu

Özbek

Emek

et al. 2018

East Mediterr Health J

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“…[ 86 ] Another study in Izmir has investigated varicella seroprevalence among 2136 healthy aged 15 years and above. [ 87 ] It has shown that VZV seropositivity was high (94.3%), and there was significant difference between VZV seroprevalence in urban and rural. Furthermore, a large proportion of the population in Izmir was naturally immunized against varicella.…”

Section: Turkeymentioning

confidence: 99%

“…Furthermore, a large proportion of the population in Izmir was naturally immunized against varicella. [ 87 ]…”

Section: Turkeymentioning

confidence: 99%

Varicella infection in the Middle East: Prevalence, complications, and vaccination

Al-Turab

Chehadeh

2018

J Res Med Sci

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Varicella (chickenpox) is the primary infection of varicella-zoster virus (VZV), it is a mild self-limiting infection, but it is also highly contagious and can cause severe complications among high-risk group of individuals. It is usually a childhood infection providing lifelong immunity, but adults without varicella history are also susceptible to infection. High-risk group of individuals is more likely to develop serious complications. Varicella vaccine was introduced to protect this group of individuals and to prevent epidemic spread of VZV infection in a community. Thus, it was added to the recommended vaccination schedules for children in most developed countries. This review aimed to outline varicella status, seroprevalence, complications, and vaccination in the Middle East region. Based on our findings, children were the most affected age group, but there are also adult cases due to high number of expatriates, especially in Gulf Cooperation Council countries. Central nervous system involvements and skin diseases followed by varicella pneumonia were the most varicella-associated complications. Varicella vaccine was introduced in most Middle East countries, either mandatory by the Ministries of Health or optional in the private clinics. Few numbers of studies have reported an obvious reduction in varicella prevalence, hospitalizations, and deaths in the Middle East following varicella vaccination. A basic database about varicella infection before the initiation and implementation of a vaccination policy is essential to determine the target group of individuals. As far as our knowledge, this is the first review about varicella infection in the Middle East.

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Seroprevalence of varicella-zoster virus in the prevaccine era: A population-based study in Izmir, Turkey

Abstract: A large proportion of the participants were found to be immune to VZV.

Cited by 12 publications

References 22 publications

Seroprevalence and Risk Factors of Varicella Zoster Infection in Iranian Adolescents: A Multilevel Analysis; The CASPIAN-III Study

Seroprevalence and Risk Factors of Varicella Zoster Infection in Iranian Adolescents: A Multilevel Analysis; The CASPIAN-III Study

Seroprevalence and social determinants of varicella in Turkey

Varicella infection in the Middle East: Prevalence, complications, and vaccination

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