Seroprevalence to Rabies Virus in Wildlife in Brazil

Fornazari, Felipe; Scheffer, K. C.; Silva, Sandriana dos Ramos; Silva, Karina Ribeiro da; Rodrigues, A. C.; Teixeira, Carlos Roberto; Rolim, Luna Scarpari; Langoni, Hélio

doi:10.7589/jwd-d-21-00065

Cited by 2 publications

(3 citation statements)

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“…The overall prevalence of rabies observed in this study, 8.86% considering all executed tests and 9.72% in RFFIT only, is slightly lower than the 11% observed in a previous study in Brazilian wild boars [ 10 ]. Rabies virus-neutralizing antibodies (RVNA) were detected in wild animals in Brazil, suggesting exposure [ 26 ] and even active infection [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…The presence of RVNA in titers ranging from 0.1 to 0.5 IU/mL suggests viral circulation among the animals, possibly due to a non-lethal or abortive infection. Despite controversies on the relevance of RVNA’s presence, they are frequently detected in bats, unvaccinated wildlife, and domestic dogs in endemic areas [ 26 , 27 , 36 ]. False positives could be the result of cytotoxic samples due to contamination during collection, as frequently noted in field research [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

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Rabies Virus-Neutralizing Antibodies in Free-Ranging Invasive Wild Boars (Sus scrofa) from Brazil

Perin,

Turmina,

Arias-Pacheco

et al. 2024

Pathogens

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Rabies, one of the most lethal global zoonoses, affects all mammals. It remains circulating worldwide in sylvatic cycles through terrestrial and airborne reservoirs, and in Brazil, bats are currently the main reservoirs and source of transmission. Wild boars, an important invasive alien species in Brazil, are a proven food source for hematophagous bats and may participate in the Brazilian sylvatic cycle of rabies. We evaluated the presence of this pathogen in hunted wild boars from the São Paulo state using histopathology, the direct fluorescent antibody test (DFA), viral isolation in cell culture (VICC), the rapid fluorescent focus inhibition test (RFFIT), and quantitative reverse transcription polymerase chain reaction (RT-qPCR). The results of histopathological, DFA, VICC, and RT-qPCR analysis were negative for all samples; seven serum samples tested positive in the RFFIT, and titers ranged from 0.13 IU/mL to 0.5 IU/mL. The presence of rabies virus-neutralizing antibodies in the studied wild boars suggests the circulation of the virus in these animals. Educative actions directed at hunters should include information on the prevention of this important zoonosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Rabies Virus-Neutralizing Antibodies in Free-Ranging Invasive Wild Boars (Sus scrofa) from Brazil

Perin,

Turmina,

Arias-Pacheco

et al. 2024

Pathogens

View full text Add to dashboard Cite

show abstract

“…Reports of RABV in opossums are scarce; their low body temperature (34.4–36.1°C [94–97°F]) and the minimal possibility of surviving an attack by a rabid animal have been suggested as probable causes of the low prevalence of this disease in opossums in North America, where wild carnivorous mammals are natural reservoirs ( 2 ). Despite the low reports of rabies in opossums, a seroprevalence study conducted in São Paulo state observed a prevalence of RABV of 1.6% (5/312) in Didelphis spp., indicating contact between this animal population and RABV ( 8 ). Neurologic signs demonstrated by the rabies-positive opossum in this study are associated with paralytic form rabies, a common form transmitted by bats ( 9 ), and detection of viral particles in other organs indicates a phase of systemic spread.…”

Section: Discussionmentioning

confidence: 94%