Seroreactivity to Human Papillomavirus Type 16 Virus‐like Particles Is Lower in High‐Risk Men than in High‐Risk Women

Svare, Edith I.; Kjær, Susanne K.; Nonnenmacher, Bernadete; Worm, Anne‐Marie; Moi, Harald; Christensen, Rene B.; Brule, Adriaan J. C. van den; Walboomers, Jan M. M.; Meijer, Chris J.L.M.; Hubbert, Nancy L.; Lowy, Douglas R.; Schiller, John T.

doi:10.1086/516505

Cited by 63 publications

(60 citation statements)

References 21 publications

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“…The lack of age association we observed in the present study of men likely reflects a sex-based variation in immune response to the virus. Men have been shown to promulgate less of a humoral response to HPV than do women [41][42][43].…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus Infection in Men Attending a Sexually Transmitted Disease Clinic

et al. 2003

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Human papillomavirus (HPV) is the main etiologic agent of anogenital cancers, including cervical cancer, but little is known about the type-specific prevalence of HPV in men. Participants were men aged 18-70 years attending a sexually transmitted disease clinic. Penile skin swabs were assessed for HPV DNA using polymerase chain reaction with reverse line-blot genotyping. Of 436 swabs collected, 90.1% yielded sufficient DNA for HPV analysis. Men with inadequate swab samples were significantly more likely to be white and circumcised than men with adequate swab samples. The prevalence of HPV was 28.2%. Oncogenic HPV types were found in 12.0% of participants, nononcogenic types were found in 14.8% of participants, multiple types were found in 6.1% of participants, and unknown types were found in 5.9% of participants. The most prevalent subtypes were nononcogenic 6, 53, and 84. HPV positivity was not associated with age. These results indicate that HPV infection among men at high risk is common but that characteristics of male HPV infection may differ from those of female infection.Human papillomavirus (HPV) infection is the necessary, sexually transmitted cause of invasive cervical cancer and its precursor lesion, cervical intraepithelial neoplasia [1][2][3]. HPV has also been closely linked with other anogenital cancers, including anal cancer and certain penile cancers [4][5][6]. HPV infection in men is over- whelmingly subclinical, which has resulted in a potentially large number of asymptomatic carriers who serve as reservoirs and vectors for the virus.Although HPV has been studied extensively in women, data on male infection are limited. Studies of HPV in men are necessary to improve our understanding of HPV transmission and HPV-related carcinogenesis and to prevent disease in both men and women. The success of future cancer prevention strategies, such as prophylactic HPV vaccination, will be limited without a basic epidemiological understanding of HPV in men.Earlier studies of papillomavirus infection in men used a variety of clinical and histological techniques to establish a diagnosis of HPV, but polymerase chain reaction (PCR) has emerged as the most sensitive method available for the detection of latent HPV [7][8][9]. Among studies that have used PCR to detect penile HPV DNA in healthy men, sampling methodologies have been inconsistent. Nonetheless, results from these diverse investigations have suggested that penile HPV in sexually active men is at least as prevalent as cervical HPV is among women [10][11][12][13][14][15].HPV prevalence in men has been shown to vary by

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Section: Discussionmentioning

confidence: 99%

Human Papillomavirus Infection in Men Attending a Sexually Transmitted Disease Clinic

et al. 2003

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“…A limited number of studies have evaluated the prevalence of HPV 16 serum antibodies and its determinants, and fewer have evaluated the prevalence of serum antibodies to other HPV types. Among 21 published studies that investigated serum antibodies to HPV 16 L1 virus-like particles (VLP) and factors associated with HPV 16 seropositivity, only 9 enrolled men (1)(2)(3)(4)(5)(6)(7)(8)(9). Only two published studies to date have examined the potential protective role of serum antibodies in subsequent infection in women (10,11) and none have been conducted in men.…”

Section: Introductionmentioning

confidence: 99%

Epidemiologic Factors Associated with Seropositivity to Human Papillomavirus Type 16 and 18 Virus–Like Particles and Risk of Subsequent Infection in Men

Hagensee

Lee

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Our understanding of humoral response to human papillomavirus (HPV) infection has been mainly derived from studies in women. The role of serum antibodies in the natural history of HPV in men has yet to be investigated. Data from 285 male participants of a natural history study were used to determine the epidemiologic factors associated with HPV 16/18 seropositivity and explore the role of HPV 16 and 18 serum antibodies in subsequent HPV infections. Serum antibodies were detected by use of HPV 16-and 18 virus-like particles enzyme-linked immunoassay. Logistic regression and Generalized Estimating Equation was used for the evaluation of risk factors. The risk of subsequent HPV infection by baseline antibody status was assessed by incidence rate ratio and its confidence intervals. Men ages 36 to 44 years compared with men ages 18 to 25 years were four times more likely to be seropositive to HPV 16/18. In addition, being divorced, separated, or widowed; being a former smoker; and having sex with men was positively and independently associated with HPV 16/18 seropositivity. Our findings on the potential role of HPV 16 or 18 serum antibodies in subsequent infection were inconclusive. Large prospective studies are warranted to adequately address questions on the role of natural immunity in the natural history of HPV infections in men. Cancer Epidemiol Biomarkers Prev; 19(2); 511-6. ©2010 AACR.

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“…Prevalence and type distribution of HPV DNA was determined from a sample (n=4821) of women aged 13 to 86 years participating in the provincial cervical cancer screening program in British Columbia (BC). Overall HPV prevalence was 16.8% (95% CI: 15.8-17.9). The prevalence of vaccine types 6, 11, 16 and 18 was 4.0 % (95% CI: 3.5-4.6), 0.2% (95% CI: 3.7-0.1-0.4.8), 10.7% (95% CI: 9.8-11.6) and 3.5% (95% CI: 3.1-4.1), respectively.…”

Section: Iii1 Femalesmentioning

confidence: 99%

“…(14) Seroprevalence studies can assist in understanding epidemiology of infection, and cumulative exposure over time and has been assessed in a limited number of studies in males. (15)(16)(17) Two population-based studies from Australia and the US have been recently published. A large populationbased sample of Australians 0 to 69 years of age showed overall seroprevalence of HPV was significantly higher among women (23.8%; 95% CI: 21.8-25.8) compared to men (17.8% [%; 95% CI: 15.7-20.0]), consistent with previous studies.…”

Section: Natural History Of Hpv Infection In Malesmentioning

confidence: 99%

“…This was considerably lower than for females (32.5%), as observed elsewhere. (12,16,17,20,21) The authors suggest that lower seroprevalence among males is likely due to differences in the immune response induced by HPV infection among males, rather than lower infection rates. (19) Large population-based studies on incidence of HPV infection in males over time are not available.…”

Section: Natural History Of Hpv Infection In Malesmentioning

confidence: 99%

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Update on Human Papillomavirus (HPV) Vaccines

Dm¹,

Mt²,

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2012

Canada Communicable Disease Report

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Seroreactivity to Human Papillomavirus Type 16 Virus‐like Particles Is Lower in High‐Risk Men than in High‐Risk Women

Cited by 63 publications

References 21 publications

Human Papillomavirus Infection in Men Attending a Sexually Transmitted Disease Clinic

Human Papillomavirus Infection in Men Attending a Sexually Transmitted Disease Clinic

Epidemiologic Factors Associated with Seropositivity to Human Papillomavirus Type 16 and 18 Virus–Like Particles and Risk of Subsequent Infection in Men

Update on Human Papillomavirus (HPV) Vaccines

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