Serostatus Testing & Dengue Vaccine Cost-Benefit Thresholds

Abstract

The World Health Organisation currently recommends pre-screening for past infection prior to administration of the only licensed dengue vaccine, CYD-TDV. Using a bounding analysis, we show that despite additional testing costs, this approach can improve the economic viability of CYD-TDV: effective testing reduces unnecessary vaccination costs while increasing the health benefit for vaccine recipients. When testing is cheap enough, those trends outweigh additional screening costs and make test-then-vaccinate strategies net-beneficial in many settings.We derived these results using a general approach for determining price thresholds for testing and vaccination, as well as indicating optimal start and end ages of routine test-then-vaccinate programs. This approach only requires age-specific seroprevalence and a cost estimate for second infections. We demonstrate this approach across settings commonly used to evaluate CYD-TDV economics, and highlight implications of our simple model for more detailed studies. We found trends showing test-then-vaccinate strategies are generally more beneficial starting at younger ages, and that in some settings multiple years of testing can be more beneficial than only testing once, despite increased investment in testing.

Designing effective control of dengue with combined interventions

“…This CYD-TDV model would still benefit seronegative recipients if they are ultimately likely to experience two or more infections (34), and therefore, declining eligibility reduces future benefits. This effect could be mediated by repeat testing (35), but we did not explore that in this work. the other is not ready to deploy, or both are available, but are too costly to start concurrently).…”