Serotonergic and BDNF Genes Associated With Depression 1 Week and 1 Year After Mastectomy for Breast Cancer

et al. 2014

Psychiatry Investig

ObjectiveWe investigated possible association between depressive disorders and BDNF Val66Met and 5-HTTLPR. Brain derived neurotrophic factor (BDNF) gene and serotonin transporter (SLC6A4) gene are promising candidate genes for depressive disorders. It has been suggested that BDNF promotes the survival and differentiation of serotonergic neurons and that serotonergic transmission exerts powerful control over BDNF gene expression.MethodsFinal analyses were performed on 186 patients with depressive disorders and 1032 controls. Val66Met polymorphism of BDNF gene and 5-HTTLPR polymorphism of serotonin transporter gene were genotyped and allele and genotypic associations on the diagnosis of depression and age at onset of depression were analyzed.ResultsThe 5-HTTLPR was positively associated with depressive affected status in the total sample and in females (p=0.038 for allelewise, p=0.015 for genotype-wise associations), but, not in males. The BDNF Val66Met showed no association with depression. BDNF Val66Met and 5-HTTLPR alone were not associated with age at onset of depression. Additional analysis on the interaction between BDNF Val66Met and 5-HTTLPR found a significant association with age at onset of depression in the entire patient group. This association was also found in the female but not in the male patient group. None of the positive results survived Bonferroni correction for multiple testing.ConclusionThis result suggested that BDNF Val66Met and 5-HTTLPR may contribute to depressive disorders in a complex way and that the genetic effect could differ by gender. Further studies with large number of patients will be necessary.

Section: Discussionsupporting

confidence: 89%

“…The A allele (Met) frequency was 46.66% in this control group, not significantly different from other studies on Korean population 26,27,30. There was no deviation from Hardy-Weinberg equilibrium for BDNF Val66Met in our sample (Table 4).…”

Section: Discussioncontrasting

confidence: 64%

Genetic Role of BDNF Val66Met and 5-HTTLPR Polymorphisms on Depressive Disorder

Lee

Jeong

et al. 2014

Psychiatry Investig

Asian Pacific Journal of Cancer Prevention

“…From our study, the prevalence of major depressive disorder in cancer patients was 29.6 %, which is in the middle range of findings of previous studies (3%-58%) (Massie and Holland, 1984;Ciaramella and Poli, 2001;Uchitomi et al, 2003;Katz et al, 2004;Ell et al, 2005;Boyd et al, 2012;Kim et al, 2012;Mitchell et al, 2012;Palmer et al, 2012;Pirl et al, 2012;Tada et al, 2012;Warmenhoven et al, 2012;Yu et al, 2012). As previous works (Bellini and Capannini, 1994;CapletteGingras and Savard, 2008), from our study shows low sensitivity of diagnosis depressive disorder (25.0 %), that means 75.0 % of patients was misdiagnosed and lacking in treatment.…”

Section: Discussionsupporting

confidence: 69%

“…Studies have found that cancer patients with depression may have behavior problems, which can worsen over the course of cancer treatment, and persist long after cancer treatment, as well as have shorter survival from poor adherence to treatment plans (Thompson & Shear, 1998;Kissane, 2009;Yu et al,Benchalak Maneeton, Narong Maneeton*, Pojai Mahathep from normal reactions to illness, through intense anxiety, to major depressive disorder (Yu et al, 2012). Patients with cancer also have depressive disorder co-morbidity 3 % -58 %, with varying prevalence because of different definitions of depression, differences in depression screening methods, and different groups of participants (Massie &Holland, 1984;Ciaramella & Poli, 2001;Uchitomi et al, 2003;Katz et al, 2004;Ell et al, 2005;Boyd et al, 2012;Kim et al, 2012;Mitchell et al, 2012;Palmer et al, 2012;Tada et al, 2012;Warmenhoven et al, 2012;Yu et al, 2012). Depressive disorder co-morbid with cancer is underestimated and under-treated (Bellini & Capannini, 1994 ;Yoshikawa, 2008;Salvo et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Depression and its Correlations: a Cross-sectional Study in Thai Cancer Patients

Maneeton

Maneeton²,

Mahathep³

2012

Objectives: Depression is common in cancer patients. However, only limited evidence is available for Asian populations. The authors therefore examine the prevalence of depression in Thai patients with cancer. In addition, associated factors were determined. Methods: This cross-sectional study was conducted in cancer patients admitted to a university hospital during December 2006 -December 2007. The Patient Health Questionnaire (PHQ-9) was used to assess all cancer patients. Suicidal risk was assessed by using the Mini-International Neuropsychiatric Interview (MINI) in the module of suicidal risk assessment. Results: Of 108 cancer patients, 29.6 % were diagnosed with a depressive disorder (mild, 14.8 %; moderate, 5.6 %; severe, 9.3 %). However, only 25.0 % of these were recognized as being depressed by the primary physician. According to the MINI., 28.1 % of these depressed cancer patients had a moderate to severe level of suicidal risk. In addition, the findings suggest that increased risk of depression is significantly associated with increased pain score, lower number of cancer treatments (< 2 methods), increased educational duration (>13 years), increased age (> 50 years old) and being female. Conclusions: The prevalence of depression is high in Thai cancer patients. However, depressive disorder in those patients is frequently undiagnosed. It is associated with several factors including pain, a number of cancer treatments, education duration, age and sex. To improve quality of life, increase compliance with treatments and prevent of suicide, screening for depressive disorders in this patient group is strongly recommended.

“…Details about the design have been published elsewhere [21]. In brief, participants were consecutively recruited from all women with breast cancer undergoing breast surgery at the Breast and Endocrine Tumor Clinic of Chonnam National University Hwasun Hospital, Hwasun, South Korea.…”

Section: Participantsmentioning

confidence: 99%

BDNF Promoter Methylation Associated with Suicidal Ideation in Patients with Breast Cancer

Kang

et al. 2015

Int J Psychiatry Med

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