Serotonergic mechanism in seizures kindled from the rabbit amygdala

Stach, R; Lazarová, Marie; Kacz, D.

doi:10.1007/bf00507228

Cited by 20 publications

(5 citation statements)

References 15 publications

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“…suggesting that the serotonergic system is involved in the suppression o f epileptic activity o f these brain regions. The discrepancy between our finding and pre vious results [8,14] that 5-HTP has the proconvulsant action is difficult to explain, and may relate to differences in primary kindled sites and different receptor involve ment in those areas. The present findings are consistent with the previous data showing the serotonergic inhibi tion o f H IP paroxysmal activity in alumina-induced and electrically induced seizure models [20,21 ].…”

Section: Discussioncontrasting

confidence: 54%

“…The administration o f 5-HTP was found to increase the rate o f amygdaloid kindling [7], while this was decreased by the administration o f p-chlorophenylalanine. an inhibitor o f serotonin synthesis [7,8]. Electro lytic lesions o f the raphe nucleus facilitated the kindling development o f the amygdala and cortex [9], Further, lesions o f serotonergic terminals in the olfactory bulb with 5,7-dihydroxytryptamine facilitate the early stages o f the kindling development o f this structure [10.…”

Section: Discussionmentioning

confidence: 99%

“…K in dling provides a viable model o f secondarily generalized seizures, and many experiments have been done to deter mine the neurophysiological and neurochemical bases of epilepsy [2], A number o f studies have provided evidence that brain serotonin plays an inhibitory role in a variety o f epilepsy models, such as electroconvulsive [3][4][5] and pen tylenetetrazol-induced seizures [4][5][6]. Serotonin has also been considered to possess an inhibitory action against the kindling development [7][8][9][10][11], but there are contradic tory results on the role o f this neurotransmitter in kindled seizures [8. 12-14].…”

Section: Introductionmentioning

confidence: 99%

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Serotonergic Inhibition of Limbic and Thalamic Seizures in Cats

Wada¹,

Hasegawa²,

Nakamura³

et al. 1992

Neuropsychobiology

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To clarify the role of the serotonergic system in limbic and thalamic epileptic activity, we examined the effects of 5-hydroxytryρtophan (5-HTP, 20 and 40 mg/kg) on fully kindled seizures from the hippocampus and lateral geniculate nucleus. The intraperitoneal administration of 20 mg/kg 5-HTP exerted no anticonvulsant effect on hippocampal kindled seizures, and a higher dose (40 mg/kg) produced a signiñcant reduction in the behavioral seizure stage. 5-HTP at 20 mg/kg displayed no suppressive effect on lateral geniculate seizures, and 5-HTP at 40 mg/kg significantly reduced both the seizure stage and afterdischarge duration. Our data suggest that serotonergic mechanisms play an inhibitory role in seizures kindled from these brain regions.

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Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serotonergic Inhibition of Limbic and Thalamic Seizures in Cats

Wada¹,

Hasegawa²,

Nakamura³

et al. 1992

Neuropsychobiology

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“…For instance, PCPA‐mediated serotonin depletion prolonged the latency of audiogenic seizures in DBA/2J mice (28) and decreased the amplitude, but not frequency, of hippocampal seizures elicited by digitoxigenin (29). Short‐ and long‐term PCPA treatment decreased the severity of seizures and delayed kindling in rats and rabbits (30, 31). Similarly, PCPA delayed amygdala kindling in rabbits but increased the severity of pentyelentetrazol‐induced convulsions in rats (32,33).…”

Section: Discussionmentioning

confidence: 99%

Serotonin Depletion Attenuates AY‐9944–Mediated Atypical Absence Seizures

et al. 2006

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Summary:Purpose: To test the hypothesis that serotonin (5-HT) plays a role in the modulation of experimental atypical absence seizures.Methods: Male Long-Evans hooded rats were treated from postnatal day (P) 2 to P20 with the cholesterol inhibitor AY-9944 (AY). Epidural electrodes were implanted for electrocorticography (ECoG) followed by serotonin depletion by using paracholorophenylalanine (PCPA). High-performance liquid chromatography (HPLC) was used to measure the levels of serotonin and its metabolite (5-HIAA) in various brain regions. Serotonin metabolism was computed by using the 5-HIAA/5-HT ratio and used to ascertain differences between groups.Results: PCPA treatment was associated with a significant decrease in the total slow spike-and-wave discharge (SSWD) duration in AY-treated rats compared with controls (p < 0.01). HPLC data confirmed the PCPA depletion of 5-HT and 5-HIAA in cortex, thalamus, hippocampus, and brainstem compared with naïve rats. AY-treated rats showed higher levels of 5-HIAA and 5-HT in the same brain regions, with a concomitant decrease in rates of serotonin turnover.Conclusions: The data indicate that serotonin depletion protects against experimental atypical absence seizures. The increased levels of 5-HIAA and 5-HT and altered rates of serotonin turnover suggest that the serotonergic neurotransmission may be perturbed in the AY rat.

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“…However, it has been shown that 5-HT 3 receptor activation reduces the release of acetylcholine (ACh) in the EC [ 64 ]. In addition, ondansetron and granisetron as 5-HT 3 receptor antagonists, in a concentration-dependent manner, increase ACh release in the entorhinal slices, while the use of 5-HT 3 receptor agonists has no effect on ACh release but completely blocks the ondansetron-induced enhancement in ACh release [ 65 ]. These results suggest that activation of 5-HT 3 receptors tonically inhibits ACh release in the EC.…”

Section: Discussionmentioning

confidence: 99%

Effect of ramosetron, a 5-HT3 receptor antagonist on the severity of seizures and memory impairment in electrical amygdala kindled rats

et al. 2022

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The entorhinal cortex (EC) plays a pivotal role in epileptogenesis and seizures. EC expresses high density of serotonergic receptors, especially 5-HT3 receptors. Cognitive impairment is common among people with epilepsy. The present study investigated the role of 5-HT3 receptor on the severity of seizures and learning and memory impairment by electrical kindling of amygdala in rats. The amygdala kindling was conducted in a chronic kindling manner in male Wistar rats. In fully kindled animals, ramosetron (as a potent and selective 5-HT3 receptor antagonist) was microinjected unilaterally (ad doses of 1, 10 or 100 µg/0.5 µl) into the EC 5 min before the novel object recognition (NOR) and Y-maze tests or kindling stimulations. Applying ramosetron at the concentration of 100 μg/0.5 µl (but not at 1 and 10 µg/0.5 µl) reduced afterdischarge (AD) duration and increased stage 4 latency in the kindled rats. Moreover, the obtained data from the NOR test showed that treatment by ramosetron (10 and 100 µg/0.5 µl) increased the discrimination index in the fully kindled animals. Microinjection of ramosetron (10 and 100 µg/0.5 µl) in fully kindled animals reversed the kindling induced changes in the percentage of spontaneous alternation in Y-maze task. The findings demonstrated an anticonvulsant role for a selective 5-HT3 receptor antagonist microinjected into the EC, therefore, suggesting an excitatory role for the EC 5-HT3 receptors in the amygdala kindling model of epilepsy. This anticonvulsive effect was accompanied with a restoring effect on cognitive behavior in NOR and Y-maze tests.

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Serotonergic mechanism in seizures kindled from the rabbit amygdala

Cited by 20 publications

References 15 publications

Serotonergic Inhibition of Limbic and Thalamic Seizures in Cats

Serotonergic Inhibition of Limbic and Thalamic Seizures in Cats

Serotonin Depletion Attenuates AY‐9944–Mediated Atypical Absence Seizures

Effect of ramosetron, a 5-HT3 receptor antagonist on the severity of seizures and memory impairment in electrical amygdala kindled rats

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