Serotonergic Neurons in Vertebrate and Invertebrate Model Organisms (Rodents, Zebrafish, Drosophila melanogaster, Aplysia californica, Caenorhabditis elegans)

Lillesaar, Christina; Gaspar, Patricia

doi:10.1016/b978-0-12-800050-2.00003-6

Cited by 13 publications

(10 citation statements)

References 166 publications

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“…Our current understanding of the development, evolution, and function of 5-HT neurotransmission is derived from different model organisms, spanning from invertebrates to vertebrates [2]. It is noteworthy that in all species, the serotonergic network is highly plastic, showing changes in its anatomical organization all through the life of the organisms.…”

Section: Serotonin Metabolismmentioning

confidence: 99%

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Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease

Crispino

Volpicelli

Perrone-Capano

2020

IJMS

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Our knowledge on the plastic functions of the serotonin (5-HT) receptor subtype 7 (5-HT7R) in the brain physiology and pathology have advanced considerably in recent years. A wealth of data show that 5-HT7R is a key player in the establishment and remodeling of neuronal cytoarchitecture during development and in the mature brain, and its dysfunction is linked to neuropsychiatric and neurodevelopmental diseases. The involvement of this receptor in synaptic plasticity is further demonstrated by data showing that its activation allows the rescue of long-term potentiation (LTP) and long-term depression (LTD) deficits in various animal models of neurodevelopmental diseases. In addition, it is becoming clear that the 5-HT7R is involved in inflammatory intestinal diseases, modulates the function of immune cells, and is likely to play a role in the gut-brain axis. In this review, we will mainly focus on recent findings on this receptor’s role in the structural and synaptic plasticity of the mammalian brain, although we will also illustrate novel aspects highlighted in gastrointestinal (GI) tract and immune system.

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Section: Serotonin Metabolismmentioning

confidence: 99%

“…5-HT metabolic pathways, reuptake, and degradation are broadly conserved among multicellular organisms [2]. 5-HT is synthesized from the amino acid tryptophan, which is an essential dietary supplement.…”

Section: Serotonin Metabolismmentioning

confidence: 99%

Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease

Crispino

Volpicelli

Perrone-Capano

2020

IJMS

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“…Neurons containing 5-HT have been identified in all major metazoan groups suggesting an early appearance of the system during animal evolution (Cornide-Petronio et al 2013). The central serotonergic system has been characterized in depth in all vertebrate classes (Sako et al 1986;Van Mier et al 1986;Adrio et al 1999;Hay-Schmidt 2000;Manger et al 2002;Lillesaar and Gaspar 2018;Lozano et al 2020) yet most studies have used specific antibodies to map serotonergic neurons. In mammalian species, central 5-HT is confined within the raphe nuclei brainstem where tph2 is expressed.…”

Section: Introductionmentioning

confidence: 99%

Distribution of two isoforms of tryptophan hydroxylase in the brain of rainbow trout (Oncorhynchus mykiss). An in situ hybridization study

et al. 2021

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Serotonin (5-HT) is one of the principal neurotransmitters in the nervous system of vertebrates. It is initially synthesized by hydroxylation of tryptophan (Trp) by means of tryptophan hydroxylase or TPH which is the rate-limiting enzyme in the production of 5-HT. In most vertebrates, there are two isoforms of TPH present, TPH1 and TPH2, which exhibit different catalytic or substrate specificity as well as different expression domains. Studies carried out in mammals show that only tph2 is expressed in the brain whereas tph1-mRNA is primarily localized in the enterochromaffin cells and pineal gland. A large number of neurons are also considered to be serotonergic or “pseudo-serotonergic” as they accumulate and release 5-HT yet do not produce it as no amine-synthetic enzymes are expressed, yet a combination of 5-HT transporters is observed. Therefore, tph expression is considered to be the only specific marker of 5-HT-producing neurons that can discriminate true 5-HT from pseudo-serotonergic neurons. This work examined in situ hybridization to study the mRNA distribution of one paralogue for tph1 and tph2 in the central nervous system of rainbow trout. Results show a segregated expression for both paralogues that predominantly match previous immunocytochemical studies. This study thus adds valuable information to the scarce analyses focusing on the central distribution of the expression of serotonergic markers, particularly tphs, in the vertebrate brain thus characterizing the true serotonergic brain territories.

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“…Drosophila suzukii larvae devour the fruit pulp within the fruits rendering them unmarketable and reducing the processed fruit exceptional [2,3]. Furthermore, the wounds created at the infested fruits throughout ovipositing provide access to secondary fungal or bacterial infections leading to additional fruit tissue disintegrate [4][5][6][7][8]. Drosophila suzukii includes exceptional kinds of hosts; for this reason, this type of agricultural pest has come to be a world major pest (Fig.…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic analysis and designing new primers for molecular identification of Drosophila suzukii

Naserzadeh

Бондаренко

Kolesnikova

et al. 2021

Vestn. Ross. univ. družby nar., Ser. Agron. životnovod.

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The family Drosophilidae includes over 3750 species worldwide and over 2000 of these are species of Drosophila. Spotted wing drosophila (SWD), Drosophila suzukii is one of the most dangerous species in this family. The insects live on undamaged ripening fruits, using its peculiar serrated ovipositor to break the skin of fresh ripening fruits and lay eggs in it. Drosophila species are very difficult and practically impossible to detect at larval stages. The present investigation was conducted at the All-Russian Plant Quarantine Center and Agrarian and Technological Institute of RUDN University, Moscow, Russia in 20182020. The aim of this study was to investigate the method of accurate and rapid identification of D. suzukii, and to design specific primer pairs for pest identification by Real-Time PCR method. The real-time quantitative PCR is a fast, sensitive, repeatable and accurate method for quantifying gene transcript levels. In this study, we designed specific primers (4.Dsuz.FRP) for Real-Time PCR to identify D. suzukii from other relative species. Although D. suzukii is absent in the Russian Federation and has not been reported so far, the project could be a precautionary measure.

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Serotonergic Neurons in Vertebrate and Invertebrate Model Organisms (Rodents, Zebrafish, Drosophila melanogaster, Aplysia californica, Caenorhabditis elegans)

Cited by 13 publications

References 166 publications

Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease

Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease

Distribution of two isoforms of tryptophan hydroxylase in the brain of rainbow trout (Oncorhynchus mykiss). An in situ hybridization study

Phylogenetic analysis and designing new primers for molecular identification of Drosophila suzukii

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