Serotonergic outcome, stress and sexual steroid hormones, and growth in a South American cichlid fish fed with an l-tryptophan enriched diet

Morandini, Leonel; Ramallo, Martín Roberto; Moreira, Renata Guimarães; Höcht, Christián; Somoza, Gustavo M.; Silva, Ana C.; Pandolfi, Matías

doi:10.1016/j.ygcen.2015.10.005

Cited by 28 publications

(18 citation statements)

References 107 publications

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“…On the other hand, only a few studies have evaluated the effects of long-term tryptophan administration on the fish stress response. Morandini et al (2015) found suppressed basal cortisol and increased brain serotonergic activity after 4 weeks tryptophan administration in Cichlasoma dimerus, with no gender-specific trend. Tejpal et al (2009 and Kumar et al (2014) showed that 45-90 days tryptophan administration under constant stressful conditions significantly suppressed cortisol and glucose responses and improved growth performance in C. mrigala and L. rohita, suggesting the need for higher tryptophan intake under stressful conditions to support maximum growth (Fig.…”

Section: Effects Of Tryptophan On 5ht Synthesis Behaviour and Stressmentioning

confidence: 79%

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Physiological roles of tryptophan in teleosts: current knowledge and perspectives for future studies

Hoseini

Pérez‐Jiménez

Costas

et al. 2017

Reviews in Aquaculture

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Tryptophan is an essential amino acid with a huge functional versatility, in addition to its participation in protein synthesis. Because of the complexity of its metabolism, and the functional relevance of several of its metabolites, it directly or indirectly participates in a wide array of physiological pathways. This amino acid is a precursor for the synthesis of the neurotransmitter/neuromodulator serotonin (5HT), the hormone melatonin and kynurenine and related compounds such as kynurenic acid, quinolinic acid or niacin. Because of this, it has a key role in the regulation of processes ranging from the neuroendocrine to the immune system in vertebrates. In aquaculture, extensive research has been performed to optimize the levels of tryptophan in the commercial diets for many fish species. Providing adequate levels of this amino acid is critically important for fish growth but also for fish welfare, as tryptophan has been shown to modulate fish behaviour, stress responses, and antioxidant and immune systems. Currently, available data suggest a wide variation in tryptophan requirements of different species ranging 0.3–1.3% of dietary protein level, but recent evidence also shows that fish tryptophan requirements can greatly vary depending on the rearing conditions of the fish. We also review here the participation of tryptophan and related metabolites in different physiological functions that are crucial for fish welfare. The review covers the involvement of tryptophan in 5HT‐ and melatonin‐mediated functions, along with its participation in the regulation of the immune system and its role as an antioxidant and antitoxic agent in fish.

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Section: Effects Of Tryptophan On 5ht Synthesis Behaviour and Stressmentioning

confidence: 79%

“…Morandini et al . () found suppressed basal cortisol and increased brain serotonergic activity after 4 weeks tryptophan administration in Cichlasoma dimerus , with no gender‐specific trend. Tejpal et al .…”

Section: Effects Of Tryptophan On 5ht Synthesis Behaviour and Stressmentioning

confidence: 93%

Physiological roles of tryptophan in teleosts: current knowledge and perspectives for future studies

Hoseini

Pérez‐Jiménez

Costas

et al. 2017

Reviews in Aquaculture

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“…Essential amino acid L-tryptophan is critical for the synthesis of 5-HT, consequently maintaining an entry-way for augmenting brain 5-HT levels by means of consuming a tryptophan-enriched diet. Accordingly, experimental animals fed a tryptophan-enriched diet exhibited higher serotonergic activity (79). Clary sage oil could be developed as a therapeutic agent for patients with depression, and the antidepressant-like effect of clary oil is closely associated with modulation of the dopamine pathway (80).…”

Section: Augmentation Of the Neuroprotective Effects Of The Serotoninmentioning

confidence: 99%

PI3K/AKT signaling mediated by G protein-coupled receptors is involved in neurodegenerative Parkinson's disease (Review)

Nakano

Matsuda

Ichimura

et al. 2016

International Journal of Molecular Medicine

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Parkinson's disease (PD) is a common progressive and multifactorial neurodegenerative disease, characterized by the loss of midbrain dopaminergic neurons. Numerous pathological processes including, inflammation, oxidative stress, mitochondrial dysfunction, neurotransmitter imbalance, and apoptosis as well as genetic factors may lead to neuronal degeneration. Motor deficits in PD are due mostly to the progressive loss of nigrostriatal dopaminergic neurons. Neuroprotection of functional neurons is of significance in the treatment of PD. G protein‑coupled receptors (GPCRs) have been implicated in the neuroprotection against PD through the survival of dopaminergic neurons. In addition, phosphatidyl‑inositol‑3‑kinase (PI3K)/AKT signaling has also been demonstrated to be neuroprotective. Knowledge of the mechanisms involved in this cellular protection could be critical for developing treatments to prevent this neurodegenerative disorder. In this review, we highlight the protective roles of the PI3K/AKT signaling pathway in the function of representative serotonin GPCRs. Particular attention is given to the molecular mechanisms of this pathway proposed to explain the favorable effects of food ingredients against neurodegenerative disease.

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“…The essential amino acid tryptophan (Trp) is a serotonin (5‐HT) precursor (Fernstrom, ) that has been used with the objective of increasing brain 5‐HT level, which usually strengthens fish capability to cope with stress using a nutritional approach (Laranja, Quinitio, Catacutan & Coloso, ; Morandini et al., ). The main limiting factor of 5‐HT synthesis, tryptophan hydroxylase (TPH) enzyme, works at medium saturation in physiological conditions; thus, higher Trp availability in the brain increases serotonin synthesis (Boadle‐Biber, ).…”

Section: Introductionmentioning

confidence: 99%

Effect of L-tryptophan supplemented diets on serotonergic system and plasma cortisol inTotoaba macdonaldi(Gilbert, 1890) juvenile exposed to acute stress by handling and hypoxia

Cabanillas‐Gámez¹,

López²,

Galavíz³

et al. 2017

Aquac Res

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Brain serotonin and cortisol play a central role in integrating the neuroendocrine response to stress. Previous studies in aquatic species show that dietary supplementation with the 5-HT precursor L-tryptophan amino acid is able to modulate this response. The aim of this study was to evaluate the effect of dietary tryptophan (Trp) on the serotonergic system and acute stress response in Totoaba macdonaldi.Four groups of fish were fed with one of four isonitrogenous and isocaloric diets formulated with different Trp content: 0.5% (1X TRP, control diet), 1.1% (2X TRP), 1.7% (3X TRP) and 2.3% (4X TRP). After a feeding period of 21 days, groups were exposed to acute stress by handling with a net or hypoxia. Feeding with Trpenriched diets resulted in increased 5-HT content in telencephalon of undisturbed fish. Handling increased the 5-hydroxyindole acetic acid (5-HIAA) and serotonin turnover (5-HIAA/5-HT) in telencephalon of fish fed with 1X TRP and 2X TRP but was not significant for the fish fed 3X TRP and 4X TRP, and no significant increase was observed by hypoxia in both telencephalon and hypothalamus in any of the diets. An inverted U-shaped response was observed in plasma cortisol increasing with 2X TRP after both handling and hypoxia and decreasing with diets rich in Trp, 3X TRP and 4X TRP. A higher increase was observed in haematocrit, plasma glucose and lactate in hypoxia than the handling groups. Our results indicate that Trp supplementation modulated cortisol response and mediated negative feedback of 5-HT system in telencephalon after acute stress. K E Y W O R D Scortisol, handling, hypoxia, serotonin turnover, totoaba, tryptophan

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Serotonergic outcome, stress and sexual steroid hormones, and growth in a South American cichlid fish fed with an l-tryptophan enriched diet

Cited by 28 publications

References 107 publications

Physiological roles of tryptophan in teleosts: current knowledge and perspectives for future studies

Physiological roles of tryptophan in teleosts: current knowledge and perspectives for future studies

PI3K/AKT signaling mediated by G protein-coupled receptors is involved in neurodegenerative Parkinson's disease (Review)

Effect of L-tryptophan supplemented diets on serotonergic system and plasma cortisol inTotoaba macdonaldi(Gilbert, 1890) juvenile exposed to acute stress by handling and hypoxia

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