Serotonergic projections to lumbar levels and its plasticity following spinal cord injury

Background: Our study shows that a membrane sealant/fiber fusogen polyethylene glycol (PEG) applied immediately on a sharp section of the spinal cord can mend the cord and lead to exceptional levels of motor recovery, with some animals almost normal. Materials and Methods: Before deploying such technology in man, long-term data in large mammals that exclude delayed complications (e.g., central pain), confirm the stability of motor recovery, and provide histological evidence of fiber regrowth are necessary. Here, we provide such evidence in dogs followed up over 6 months and in 2 cases up to 1 year along with imaging and histologic data. Results: We show that dogs whose dorsal cord has been fully transected recover locomotion after immediate treatment with a fusogen (PEG). No pain syndrome ensued over the long term. Diffusion tensor imaging magnetic resonance and histological, including immunohistochemical, data confirmed the re-establishment of anatomical continuity along with interfacial axonal sprouting. Conclusions: This study proves that a form of irreversible spinal cord injury (SCI) can effectively be treated and points out a way to treat SCI patients.

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Section: Discussionmentioning

confidence: 99%

Reconstruction of the spinal cord of spinal transected dogs with polyethylene glycol

Ren

Liu

Kim

et al. 2019

Surgical Neurology International

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“…[7] Part of the regrowing fibers are serotonergic: the descending serotonergic pathway, which originates in various populations of brainstem neurons, plays an important role in generating the rhythmic motor pattern associated with locomotor movement and establishes direct connections with lumbar motoneurons. [12] Given the excellent recovery, the sprouting process in the TRPS does not appear to be haphazard, with disruptive misalignments. In any case, circuital readjustment in the spinal cord and within upper CNS stations is known to play a key role in recovery from spinal cord injuries (SCI).…”

Section: Discussionmentioning

confidence: 99%

Untitled

2019

Surg Neurol Int

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Background:Our study shows that a membrane sealant/fiber fusogen polyethylene glycol (PEG) applied immediately on a sharp section of the spinal cord can mend the cord and lead to exceptional levels of motor recovery, with some animals almost normal.Materials and Methods: Before deploying such technology in man, long-term data in large mammals that exclude delayed complications (e.g., central pain), confirm the stability of motor recovery, and provide histological evidence of fiber regrowth are necessary. Here, we provide such evidence in dogs followed up over 6 months and in 2 cases up to 1 year along with imaging and histologic data. Results:We show that dogs whose dorsal cord has been fully transected recover locomotion after immediate treatment with a fusogen (PEG). No pain syndrome ensued over the long term. Diffusion tensor imaging magnetic resonance and histological, including immunohistochemical, data confirmed the re-establishment of anatomical continuity along with interfacial axonal sprouting.Conclusions: is study proves that a form of irreversible spinal cord injury (SCI) can effectively be treated and points out a way to treat SCI patients.

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“…17,27 Even though the proportion of serotonergic RVM neurons projecting to the spinal cord does not change during the first postnatal week, the number of serotonergic axons increases in the dorsal horn as fibers grow and sprout further, and innervation follows a rostral to caudal and ventral to dorsal gradient. 17,25,[28][29][30] Overall, spinal 5-HT axon innervation maturing from rostral to caudal could indicate serotonergic modulation of the spinal dorsal horn, and therefore sensitivity, develops earlier at the cervical level followed by lower (thoracic and lumbar) levels in neonates. 25,28,31 The ventral to dorsal gradient ensures that the first serotonergic fibers invade the deeper dorsal horn around birth in rodents, and their innervation increases progressively throughout the cord in the first few postnatal days.…”

Section: Serotonergic Descending Modulation Of Nociception During The...mentioning

confidence: 99%

The development of descending serotonergic modulation of the spinal nociceptive network: a life span perspective

et al. 2021

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Serotonergic projections to lumbar levels and its plasticity following spinal cord injury

Cited by 13 publications

References 33 publications

Reconstruction of the spinal cord of spinal transected dogs with polyethylene glycol

Reconstruction of the spinal cord of spinal transected dogs with polyethylene glycol

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The development of descending serotonergic modulation of the spinal nociceptive network: a life span perspective

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