Serotonergic Properties of the Roots of Clerodendron capitatum

Ibrahim, Mohamed Yousif; Wahab, Abdel; Mohamed, Abdel Wahab Hassan; Mohamed, Osama Y; Abdul, Ahmad Bustamam; Al-Zubairi, Adel Sharaf

doi:10.3844/ajbbsp.2008.425.430

Cited by 8 publications

(4 citation statements)

References 22 publications

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“…Administration of cyproheptadine (0.2 µmol) resulted in 86% suppression of uterine smooth muscle contractions stimulated by M. pruriens (Table 1). This observation is in agreement with the findings of other investigators where cyproheptadine was reported to cause powerful inhibition of serotonin induced contraction [27,28,29]. Thus, the contractile activity of M. pruriens in the present study, may have been derived from its serotonin content and its direct stimulation of 5-HT receptors at a low concentration.…”

Section: Discussionsupporting

confidence: 94%

Mechanism of Spasmogenic Activity Stimulated by Aqueous Ethanolic Leaf Extract of Mucuna pruriens on Isolated Uterine Muscle of Albino Rats

Francis¹,

Uchendu

Obidike

2019

JPRI

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Aims: To investigate the effect of aqueous ethanolic leaf extract of this medicinal plant on isolated uterine smooth muscle strips of the rat and to determine its mechanism of action. Study Design: Laboratory-experimental design was used in this study. Place and Duration of Study: The study was carried out in the Department of Veterinary Physiology and Biochemistry of Michael Okpara University of Agriculture, Umudike, Nigeria, Department of Pharmacology and Toxicology of the Faculty of Pharmacy, University of Nigeria, Nsukka, and the Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria between June and October 2014. Methodology: Fresh leaves of Mucuna pruriens were identified and collected by a taxonomist from Nsukka, Nigeria. The leaves were then air dried and pulverized into powder. This was then subjected to cold extraction using petroleum ether (70-90) and 70% aqueous ethanol, after which the extract was left to dry at room temperature. Estrogenised uterine strips (12mm) were harvested from non-pregnant, sexually matured albino rats (180 g -250 g) and suspended in a 35ml organ bath containing Krebs’ physiological salt solution. The organ bath was connected to an isometric electronic force displacement transducer and a physiograph. Drugs such as Salbutamol, Isoprenaline, Adrenaline, Propranolol, Atipamezole and Prazosin were used as either agonists or antagonists to determine the mechanism of action of the extract. Atropine sulphate and Cyproheptadine were also used as test drugs. Concentrations of these drugs presented in the body of this work represent the final nutrient bath concentrations. Results: M. pruriens caused a dose -dependent increase in uterine muscle contraction with an EC50 of 0.88 mg/ml, n=4. The contraction was unaffected by atropine sulphate (0.042 µmol), but abolished by salbutamol (0.012-0.4 µmol), isoprenaline (0.06-0.23 µmol), and adrenaline (16 nmol). The uterine muscle contractions were enhanced by propranolol (1 µmol) in a dose- dependent manner. Prazosin (0.069-0.14 µmol) and atipamezole (3.3-13.7 nmol) were unable to abolish contractions stimulated by the extract. However, 0.2 µmol of cyproheptadine caused 80% suppression of the extract –induced uterine contraction Conclusion: It is concluded that aqueous ethanolic leaf extract of M. pruriens, has ability to cause uterine smooth muscle contraction hence, justifies its reported use traditionally as a uterine stimulant. This contraction is most likely exerted via the 5-HT receptor activation (activated by low concentrations of serotonin).

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Section: Discussionsupporting

confidence: 94%

Mechanism of Spasmogenic Activity Stimulated by Aqueous Ethanolic Leaf Extract of Mucuna pruriens on Isolated Uterine Muscle of Albino Rats

Francis¹,

Uchendu

Obidike

2019

JPRI

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“…A genus of flowering plants in the family Lamiaceae is called Clerodendrum [1]. In traditional medicine, the species in the genus is used for a variety of purposes due to its antihypertensive, sedative, analgesic, and anti-inflammatory properties, according to pharmacological research [2,3]. The members of this genus thrive in tropical and warm temperate regions worldwide, with the highest concentration found in tropical Africa and southern Asia.…”

Section: Introductionmentioning

confidence: 99%

Ethnomedicinal application, phytochemistry and therapeutic effects of genus clerodendrum

Ogunlakin,

Akinwumi,

Ambali

2023

FFS

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The genus Clerodendrum consist of flowering plants, which was once classified as a member of the Verbenaceae family, was recently classified as a member of the Lamiaceae family. Various species of this genus have been generally used for treating several ailments and disorders as well as ornamental plants. Secondary metabolites found in abundance in these species include terpenoids, saponins, carbohydrates, and glucosides as well as alkaloids, flavonoids, and phenolic compounds. Studies conducted so far have shown that the extracts and compounds of the species in this genus exert diverse physiological activities, including anti-inflammatory, anti-diabetic, antihypertensive, anti-allergic, analgesic, hepatoprotective, post-coital antifertility, antimicrobial, anticholinesterase, membrane stabilizing, antihelmitic, hypolipidemic, antitumor, and antimicrobial properties. Medicinal plants in this genus are beneficial, therefore they should be considered as lead in drug discovery and formulation.Keywords: Clerodendrum species, Forkloric uses, Pharmacological application, Phytoconstituents, Therapeutics

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“…Herbal effects obsrved in diffirent cases (Abdel Wahab et al, 2008;Alhusseini et al, 2010;Balasubramanyam et al, 2006;Hajati et al, 2011;Khaled and Belbraouet, 2009;Mahfouz et al, 2010;Mansi, 2006;Pulakat et al, 2008;Sulaiman et al, 2009;Zhou et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Excess Body Fat Elimination (Anti-Obesity) Effects of <i>Vernonia Amygdalina</i> Leaf Extract

Anastasi¹

2011

American Journal of Pharmacology and Toxicology

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Problem statement: Many obese or overweight persons complain that they don't know what makes them fat. They would also like to know how to loss excess fat and maintain the fat loss. Approach: This research study was structured to make the obesed subject loose excess fat and at the same time learn what makes people fat so that in the future they would prevent developing obesity by eating proper diets. Results: Thirty nine obese human subjects took Vernonia amygdalina leaf extract orally for one month. The subjects were required to adhere to dietary restrictions during the treatment period. The dietary restrictions included abstaining from fattening foods, soups and stews or gravy; acidic beverages; soft drinks; acidic/spicy foods, soups, stews, drinks; artificial seasoning; alcohol; tobacco and consumption of large quantities of carbohydrates. Thirty seven of the subjects who obeyed the dietary restrictions lost 16 kg of excess body fat in one month. One of the subjects who also adhered to the dietary restrictions of the treatment lost 15 kg of excess body fat. The subject who kept all the dietary restrictions except the consumption of alcohol and the consumption of two thirds of formerly consumed carbohydrates; lost 10 kg of excess body fat. These results show that V. amygdalina leaf has specific and efficacious excess body fat elimination (anti-obesity) properties. Conclusion:The results of the study enable us to conclude that the excess fat elimination effects of V. amygdalina leaf extract can be antagonized by consumption of excess calories like those provided by alcohol, the consumption of acidic foods and drinks. The consumption of three thirds leafy vegetable equivalent of a certain amount of carbohydrates together with required daily amounts of proteins, minerals, vitamins and water enables one to avoid accumulation of excess body fat.

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Serotonergic Properties of the Roots of Clerodendron capitatum

Cited by 8 publications

References 22 publications

Mechanism of Spasmogenic Activity Stimulated by Aqueous Ethanolic Leaf Extract of Mucuna pruriens on Isolated Uterine Muscle of Albino Rats

Mechanism of Spasmogenic Activity Stimulated by Aqueous Ethanolic Leaf Extract of Mucuna pruriens on Isolated Uterine Muscle of Albino Rats

Ethnomedicinal application, phytochemistry and therapeutic effects of genus clerodendrum

Excess Body Fat Elimination (Anti-Obesity) Effects of <i>Vernonia Amygdalina</i> Leaf Extract

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