Serotonergic regulation of inhibitory avoidance and one-way escape in the rat elevated T-maze

Zangrossi, Hélio; Viana, Milena de Barros; Zanoveli, Janaína Menezes; Bueno, Cíntia Heloína; Nogueira, Ricardo de Carvalho; Graeff, Frederico Guilherme

doi:10.1016/s0149-7634(01)00047-1

Cited by 96 publications

(75 citation statements)

References 58 publications

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“…which blocks NMDA-evoked neural activity [10]. Our results are not concordant with some researchers' result [24,25]. However, this discrepancy may have been caused by differences in species and age of animals used.…”

Section: Discussioncontrasting

confidence: 89%

Can propolis be protective against ethanol-impaired anxiety and unconditional fear?

Doğan¹,

Emre²

2015

Med-Science

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Section: Discussioncontrasting

confidence: 89%

Can propolis be protective against ethanol-impaired anxiety and unconditional fear?

Doğan¹,

Emre²

2015

Med-Science

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“…5-HT-producing neurons in the dorsal raphe nucleus (DRN) provide the majority of 5-HT innervations mainly to lateral forebrain areas, such as the basal ganglia, amygdala, and prefrontal cortex (Jacobs and Azmitia, 1992). Activation of 5-HTergic neurons in the DRN facilitates learned defensive behaviors (Zangrossi et al, 2001), while their inhibition by microinjection of GABA or benzodiazepine chlordiazepoxide exerts anxiolytic effects that attenuate suppression of conditioned punishing stimulus on lever-pressing behavior (Thiébot et al, 1980). Thus, 5-HT released from DRN neurons plays an important role in the regulation of anxiety responses.…”

Section: Introductionmentioning

confidence: 99%

Distinct Neurochemical and Functional Properties of GAD67-Containing 5-HT Neurons in the Rat Dorsal Raphe Nucleus

Shikanai

Yoshida²,

Konno

et al. 2012

J. Neurosci.

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The serotonergic (5-HTergic) system arising from the dorsal raphe nucleus (DRN) is implicated in various physiological and behavioral processes, including stress responses. The DRN is comprised of several subnuclei, serving specific functions with distinct afferent and efferent connections. Furthermore, subsets of 5-HTergic neurons are known to coexpress other transmitters, including GABA, glutamate, or neuropeptides, thereby generating further heterogeneity. However, despite the growing evidence for functional variations among DRN subnuclei, relatively little is known about how they map onto neurochemical diversity of 5-HTergic neurons. In the present study, we characterized functional properties of GAD67-expressing 5-HTergic neurons (5-HT/GAD67 neurons) in the rat DRN, and compared with those of neurons expressing 5-HTergic molecules (5-HT neurons) or GAD67 alone. While 5-HT/GAD67 neurons were absent in the dorsomedial (DRD) or ventromedial (DRV) parts of the DRN, they were selectively distributed in the lateral wing of the DRN (DRL), constituting 12% of the total DRL neurons. They expressed plasmalemmal GABA transporter 1, but lacked vesicular inhibitory amino acid transporter. By using whole-cell patch-clamp recording, we found that 5-HT/GAD67 neurons had lower input resistance and firing frequency than 5-HT neurons. As revealed by c-Fos immunohistochemistry, neurons in the DRL, particularly 5-HT/GAD67 neurons, showed higher responsiveness to exposure to an open field arena than those in the DRD and DRV. By contrast, exposure to contextual fear conditioning stress showed no such regional differences. These findings indicate that 5-HT/GAD67 neurons constitute a unique neuronal population with distinctive neurochemical and electrophysiological properties and high responsiveness to innocuous stressor.

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“…Activation of 5-HT 1B , 5-HT 2C and 5-HT 4 receptors by systemic injection of receptor agonists reduces the time spent on the open arm of the elevated plus-maze (Lin and Parsons, 2002;Setem et al, 1999;Smriga and Torii, 2003). 5-HT 2B/2C receptor agonists increase, and 5-HT 2B/2C receptor antagonists decrease the avoidance latency in the elevated T-maze (Graeff et al, 1998;Zangrossi et al, 2001). 5-HT 1A receptor agonists increase the time spent on the open arm of the elevated plus-maze (Collinson and Dawson, 1997) and reduce the avoidance latency in the elevated T-maze (Zangrossi et al, 2001).…”

Section: Anxiety-like Behaviormentioning

confidence: 99%

“…5-HT 2B/2C receptor agonists increase, and 5-HT 2B/2C receptor antagonists decrease the avoidance latency in the elevated T-maze (Graeff et al, 1998;Zangrossi et al, 2001). 5-HT 1A receptor agonists increase the time spent on the open arm of the elevated plus-maze (Collinson and Dawson, 1997) and reduce the avoidance latency in the elevated T-maze (Zangrossi et al, 2001). Therefore, the results suggest that chronic SSRI-treatment during adolescence in rats leads to sustained changes in 5-HT neurotransmission or functioning of 5-HT receptors involved in anxiety-like behavior.…”

Section: Anxiety-like Behaviormentioning

confidence: 99%

Effects of chronic treatment with fluvoxamine and paroxetine during adolescence on serotonin-related behavior in adult male rats

Jong

Snaphaan

Pattij

et al. 2006

European Neuropsychopharmacology

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Selective Serotonin Reuptake Inhibitors (SSRIs) are designed to treat adults, but are increasingly prescribed for adolescents. SSRIs might cause permanent changes in serotonin-related behavior in adolescents, since their serotonergic system is still developing.Male Wistar rats were treated with paroxetine (15 mg/kg p.o.) or fluvoxamine (30 mg/kg p.o.) throughout adolescence. After a washout period their behavior in the elevated plusmaze, prepulse inhibition test, Forced swimming test and elevated T-maze were studied. In addition, the effects of the 5-HT 1A receptor agonist 8-OH-DPAT on sexual behavior and lower lip retraction were measured. Paroxetine mildly inhibited weight gain during treatment. Both SSRIs caused a reduction in ejaculation frequency and in time spent on the open arm of the elevated plus-maze in adult rats. avoidance latency in the elevated T-maze compared to paroxetine. No differences between the groups were found in the other tests. Apparently, chronic treatment with SSRIs during adolescence may cause mild changes in adult behavior.

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Serotonergic regulation of inhibitory avoidance and one-way escape in the rat elevated T-maze

Cited by 96 publications

References 58 publications

Can propolis be protective against ethanol-impaired anxiety and unconditional fear?

Can propolis be protective against ethanol-impaired anxiety and unconditional fear?

Distinct Neurochemical and Functional Properties of GAD67-Containing 5-HT Neurons in the Rat Dorsal Raphe Nucleus

Effects of chronic treatment with fluvoxamine and paroxetine during adolescence on serotonin-related behavior in adult male rats

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