Serotonin-2C and serotonin-1A receptor genes are not associated with psychotic symptomatology of mood disorders

Abstract

The serotonergic system is involved in both pathophysiology and treatment of mood disorders. In the present study we investigated the possible influence of the polymorphisms of the serotonin-1A and 2C receptor genes on the symptomatology of mood disorders. Eighty-four inpatients affected by mood disorders (72 bipolar and 12 major depressive disorder) were assessed by the Operational Criteria Checklist for Psychotic Illness to score their lifetime psychotic symptomatology. The subjects were also typed for 5HT1A and 5HT2C variants using polymerase chain reaction techniques. No association was found between 5HT2C and psychopathology as defined by the four symptomatologic factors used as phenotype definition (mania, depression, delusion, and disorganization) even when bipolar subjects were analyzed separately. Only one subject with the 5HT1A variant was observed. Genetic variation at the 5HT1A and 5HT2C receptor genes does not, therefore, play a major role in the pathogenesis of mood disorders symptomatology. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:161-166, 2000.

Serotonin-2A and 2C Receptor Gene Polymorphisms in Japanese Patients with Obstructive Sleep Apnea

“…For the HTR2A and HTR2C receptor genotyping, the polymerase chain reaction (PCR)-restriction fragment length polymorphism method was performed (24,25). The 102T/C polymorphism in the HTR2A was detected using the oligonucleotide primers 5´-TCTGCTACAAGTTC TGGCTT-3´and 5´-CTGCAGCTTTTTCTCTAGGG-3´to amplify a 342-bp segment covering the polymorphic site.…”

Analysis of structural polymorphisms and C-1018G promoter variant of the 5-HT1A receptor gene as putative risk factors in major depression

“…6,7 Previous association studies investigating the putative role of the 5-HT 1A receptor gene in schizophrenia and major depression have failed to demonstrate any relation between these polymorphisms and the disorders. [6][7][8] Recently, a novel and relatively common polymorphism (C-1018G) that may provide useful information on the involvement of this receptor gene in mental disorders, has been described on the promoter region of the 5-HT 1A receptor gene. 9 We hypothesised that genetic variation in the 5-HT 1A receptor gene could be involved in the aetiology of major depression or in clinical features related to this complex disorder.…”

Serotonin 5-HT2Receptor Interactions with Dopamine Function: Implications for Therapeutics in Cocaine Use Disorder

“…The HTR 2A A(-1438)G SNP was associated with response inhibition in two specific behavioral tasks in normal subjects (Nomura et al, 2006) and impulsive behavior in bulimia (Bruce et al, 2005).The HTR 2A T10 2C SNP is associated with impulse control in cocaine-dependent subjects (Bjork et al, 2002). A SNP (rs6318) identified in the coding region of the 5-HT 2C R that converts a cysteine (Cys) to a serine (Ser) at amino acid codon 23 in the N-terminal extracellular domain (Ser23 variant) (Lappalainen et al, 1995) has been implicated in the pathogenesis of psychiatric disorders (Burnet et al, 1999;Frisch et al, 2000;Serretti et al, 2000;Lerer et al, 2001). Recently, cocaine-dependent subjects carrying the Ser23 variant were shown to display significantly higher cue reactivity (Anastasio et al, 2014a).…”