2015
DOI: 10.1016/j.bone.2014.11.008
|View full text |Cite
|
Sign up to set email alerts
|

Serotonin (5-HT) inhibits Factor XIII-A-mediated plasma fibronectin matrix assembly and crosslinking in osteoblast cultures via direct competition with transamidation

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

0
32
0

Year Published

2015
2015
2024
2024

Publication Types

Select...
5
2

Relationship

1
6

Authors

Journals

citations
Cited by 24 publications
(32 citation statements)
references
References 66 publications
0
32
0
Order By: Relevance
“…Peripheral serotonin produced in the gut contributes to circulating serotonin levels and is a negative regulator of osteoblast proliferation, bone mass, and quality [85, 86]. This negative modulation on bone is thought to be mediated by serotonin receptors and transporter in osteoblasts and osteoclasts.…”
Section: Adipose Tissue In Control Of Bone Massmentioning
confidence: 99%
See 2 more Smart Citations
“…Peripheral serotonin produced in the gut contributes to circulating serotonin levels and is a negative regulator of osteoblast proliferation, bone mass, and quality [85, 86]. This negative modulation on bone is thought to be mediated by serotonin receptors and transporter in osteoblasts and osteoclasts.…”
Section: Adipose Tissue In Control Of Bone Massmentioning
confidence: 99%
“…This negative modulation on bone is thought to be mediated by serotonin receptors and transporter in osteoblasts and osteoclasts. In addition, Cui et al suggest that serotonin can bind covalently with proteins, by transglutaminase-mediated serotonylation reaction, modifying their function [86]. These authors explain that serotonin has significant interactions with plasma fibronectin, interfering on bone extracellular matrix assembly and mineralization; hence, increased peripheral serotonin concentrations may weaken bone matrix and negatively affect bone quality and mass [86].…”
Section: Adipose Tissue In Control Of Bone Massmentioning
confidence: 99%
See 1 more Smart Citation
“…Serotonylation of fibronectin in the extracellular matrix of osteoblast cultures inhibits stabilization of the extracellular matrix. 16 fibronectin was similar, suggesting that the same glutamine sites are modified by each monoamine. However, the affinities for incorporation varied, with NA having the highest affinity (154 nM), followed by DA (448 nM) and then 5-HT (749 nM).…”
Section: ■ Targets For Monoaminylationmentioning
confidence: 80%
“…However, FXIIIA has been shown to be capable of catalyzing serotonylation of extracellular fibronectin in osteoblast cell cultures. 16 …”
mentioning
confidence: 97%